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Q8G3N6

- IMDH_BIFLO

UniProt

Q8G3N6 - IMDH_BIFLO

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Protein

Inosine-5'-monophosphate dehydrogenase

Gene

guaB

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei295 – 2951NADUniRule annotation
Metal bindingi349 – 3491Potassium; via carbonyl oxygenUniRule annotation
Metal bindingi351 – 3511Potassium; via carbonyl oxygenUniRule annotation
Binding sitei352 – 3521IMPUniRule annotation
Active sitei354 – 3541Thioimidate intermediateUniRule annotation
Metal bindingi354 – 3541Potassium; via carbonyl oxygenUniRule annotation
Binding sitei470 – 4701IMPUniRule annotation
Metal bindingi524 – 5241Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
Metal bindingi525 – 5251Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation
Metal bindingi526 – 5261Potassium; via carbonyl oxygen; shared with tetrameric partnerUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi347 – 3493NADUniRule annotation

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

BioCyciBLON206672:GI1E-1707-MONOMER.
UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenaseUniRule annotation (EC:1.1.1.205UniRule annotation)
Short name:
IMP dehydrogenaseUniRule annotation
Short name:
IMPDUniRule annotation
Short name:
IMPDHUniRule annotation
Gene namesi
Name:guaBUniRule annotation
Ordered Locus Names:BL1722
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000000439: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Inosine-5'-monophosphate dehydrogenasePRO_0000415688Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi206672.BL1722.

Structurei

3D structure databases

ProteinModelPortaliQ8G3N6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 19457CBS 1UniRule annotationAdd
BLAST
Domaini201 – 25858CBS 2UniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni387 – 3893IMP bindingUniRule annotation
Regioni410 – 4112IMP bindingUniRule annotation
Regioni434 – 4385IMP bindingUniRule annotation

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.UniRule annotation
Contains 2 CBS domains.UniRule annotation

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

HOGENOMiHOG000165755.
KOiK00088.
OMAiFQADVRS.
OrthoDBiEOG6GTZPV.
PhylomeDBiQ8G3N6.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G3N6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRCRTRQRIS ERSQACVVKV SACSYSVCMA TNLDELNAQS AYAPLPPIFA
60 70 80 90 100
KLGLAYDDVL LLPNETDVIP SEVDTSTHLT RKIVMKAPVL SAAMDTVTES
110 120 130 140 150
EMAIAMARNG GIGVLHRNLS IDDQAAQVDV VKRSESGMIT DPLTVNPEVT
160 170 180 190 200
LADLDKLCGK FHISGLPVVD KENKLVGIIT NRDMRFIASE DYDTLKVKDV
210 220 230 240 250
MTKENLVTGP SNISKDDAHR LLAQHKVEKL PLVDEEGHLT GLITVKDFVK
260 270 280 290 300
TEQYPDATKD EQGRLRVAAG VGFLGDAWQR ASALMEAGVD VLVVDTANGE
310 320 330 340 350
ARLALDMISR LKHDSAFDGV QIIGGNVGTR SGAQAMIEAG ADAVKVGIGP
360 370 380 390 400
GSICTTRIVA GVGVPQLTAV YEAAQACRAA GVPCIADGGI HYSGDIAKAL
410 420 430 440 450
VAGASSVMLG GTLAGCEEAP GEKVLLHGKQ YKLYRGMGSL GAMAPRGKKS
460 470 480 490 500
YSKDRYFQAD VTSSDKVVPE GVEGEVPYRG PLNAVLYQML GGLHQSMFYI
510 520 530 540
GAHNIAEMPE RGKFIRITDA GLRESHPHDI VMTTEAPNYS GFHNN
Length:545
Mass (Da):58,263
Last modified:March 1, 2003 - v1
Checksum:iE56CD074DAF63CD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN25506.1.
RefSeqiNP_696870.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN25506; AAN25506; BL1722.
GeneIDi1021976.
KEGGiblo:BL1722.
PATRICi21120714. VBIBifLon107831_1776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN25506.1 .
RefSeqi NP_696870.1. NC_004307.2.

3D structure databases

ProteinModelPortali Q8G3N6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 206672.BL1722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN25506 ; AAN25506 ; BL1722 .
GeneIDi 1021976.
KEGGi blo:BL1722.
PATRICi 21120714. VBIBifLon107831_1776.

Phylogenomic databases

HOGENOMi HOG000165755.
KOi K00088.
OMAi FQADVRS.
OrthoDBi EOG6GTZPV.
PhylomeDBi Q8G3N6.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .
BioCyci BLON206672:GI1E-1707-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
    Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
    Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCC 2705.

Entry informationi

Entry nameiIMDH_BIFLO
AccessioniPrimary (citable) accession number: Q8G3N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3