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Q8G3N6

- IMDH_BIFLO

UniProt

Q8G3N6 - IMDH_BIFLO

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Protein

Inosine-5'-monophosphate dehydrogenase

Gene
guaB, BL1722
Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth By similarity.UniRule annotation

Catalytic activityi

Inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH.UniRule annotation

Cofactori

Potassium By similarity.UniRule annotation

Enzyme regulationi

Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei295 – 2951NAD By similarity
Metal bindingi349 – 3491Potassium; via carbonyl oxygen By similarity
Metal bindingi351 – 3511Potassium; via carbonyl oxygen By similarity
Binding sitei352 – 3521IMP By similarity
Active sitei354 – 3541Thioimidate intermediate By similarity
Metal bindingi354 – 3541Potassium; via carbonyl oxygen By similarity
Binding sitei470 – 4701IMP By similarity
Metal bindingi524 – 5241Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi525 – 5251Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity
Metal bindingi526 – 5261Potassium; via carbonyl oxygen; shared with tetrameric partner By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi347 – 3493NAD By similarity

GO - Molecular functioni

  1. adenyl nucleotide binding Source: InterPro
  2. IMP dehydrogenase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. GMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

GMP biosynthesis, Purine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Potassium

Enzyme and pathway databases

BioCyciBLON206672:GI1E-1707-MONOMER.
UniPathwayiUPA00601; UER00295.

Names & Taxonomyi

Protein namesi
Recommended name:
Inosine-5'-monophosphate dehydrogenase (EC:1.1.1.205)
Short name:
IMP dehydrogenase
Short name:
IMPD
Short name:
IMPDH
Gene namesi
Name:guaB
Ordered Locus Names:BL1722
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000000439: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545Inosine-5'-monophosphate dehydrogenaseUniRule annotationPRO_0000415688Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi206672.BL1722.

Structurei

3D structure databases

ProteinModelPortaliQ8G3N6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini138 – 19457CBS 1Add
BLAST
Domaini201 – 25858CBS 2Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni387 – 3893IMP binding By similarity
Regioni410 – 4112IMP binding By similarity
Regioni434 – 4385IMP binding By similarity

Sequence similaritiesi

Belongs to the IMPDH/GMPR family.
Contains 2 CBS domains.

Keywords - Domaini

CBS domain, Repeat

Phylogenomic databases

HOGENOMiHOG000165755.
KOiK00088.
OMAiFQADVRS.
OrthoDBiEOG6GTZPV.
PhylomeDBiQ8G3N6.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01964. IMPDH.
InterProiIPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view]
PANTHERiPTHR11911:SF6. PTHR11911:SF6. 1 hit.
PfamiPF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view]
PIRSFiPIRSF000130. IMPDH. 1 hit.
SMARTiSM00116. CBS. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01302. IMP_dehydrog. 1 hit.
PROSITEiPS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G3N6-1 [UniParc]FASTAAdd to Basket

« Hide

MRCRTRQRIS ERSQACVVKV SACSYSVCMA TNLDELNAQS AYAPLPPIFA    50
KLGLAYDDVL LLPNETDVIP SEVDTSTHLT RKIVMKAPVL SAAMDTVTES 100
EMAIAMARNG GIGVLHRNLS IDDQAAQVDV VKRSESGMIT DPLTVNPEVT 150
LADLDKLCGK FHISGLPVVD KENKLVGIIT NRDMRFIASE DYDTLKVKDV 200
MTKENLVTGP SNISKDDAHR LLAQHKVEKL PLVDEEGHLT GLITVKDFVK 250
TEQYPDATKD EQGRLRVAAG VGFLGDAWQR ASALMEAGVD VLVVDTANGE 300
ARLALDMISR LKHDSAFDGV QIIGGNVGTR SGAQAMIEAG ADAVKVGIGP 350
GSICTTRIVA GVGVPQLTAV YEAAQACRAA GVPCIADGGI HYSGDIAKAL 400
VAGASSVMLG GTLAGCEEAP GEKVLLHGKQ YKLYRGMGSL GAMAPRGKKS 450
YSKDRYFQAD VTSSDKVVPE GVEGEVPYRG PLNAVLYQML GGLHQSMFYI 500
GAHNIAEMPE RGKFIRITDA GLRESHPHDI VMTTEAPNYS GFHNN 545
Length:545
Mass (Da):58,263
Last modified:March 1, 2003 - v1
Checksum:iE56CD074DAF63CD3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN25506.1.
RefSeqiNP_696870.1. NC_004307.2.

Genome annotation databases

EnsemblBacteriaiAAN25506; AAN25506; BL1722.
GeneIDi1021976.
KEGGiblo:BL1722.
PATRICi21120714. VBIBifLon107831_1776.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014295 Genomic DNA. Translation: AAN25506.1 .
RefSeqi NP_696870.1. NC_004307.2.

3D structure databases

ProteinModelPortali Q8G3N6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 206672.BL1722.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN25506 ; AAN25506 ; BL1722 .
GeneIDi 1021976.
KEGGi blo:BL1722.
PATRICi 21120714. VBIBifLon107831_1776.

Phylogenomic databases

HOGENOMi HOG000165755.
KOi K00088.
OMAi FQADVRS.
OrthoDBi EOG6GTZPV.
PhylomeDBi Q8G3N6.

Enzyme and pathway databases

UniPathwayi UPA00601 ; UER00295 .
BioCyci BLON206672:GI1E-1707-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01964. IMPDH.
InterProi IPR013785. Aldolase_TIM.
IPR000644. CBS_dom.
IPR005990. IMP_DH.
IPR015875. IMP_DH/GMP_Rdtase_CS.
IPR001093. IMP_DH_GMPRt.
[Graphical view ]
PANTHERi PTHR11911:SF6. PTHR11911:SF6. 1 hit.
Pfami PF00571. CBS. 2 hits.
PF00478. IMPDH. 1 hit.
[Graphical view ]
PIRSFi PIRSF000130. IMPDH. 1 hit.
SMARTi SM00116. CBS. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01302. IMP_dehydrog. 1 hit.
PROSITEi PS51371. CBS. 2 hits.
PS00487. IMP_DH_GMP_RED. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum reflects its adaptation to the human gastrointestinal tract."
    Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G., Zwahlen M.-C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.
    Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NCC 2705.

Entry informationi

Entry nameiIMDH_BIFLO
AccessioniPrimary (citable) accession number: Q8G3N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: March 1, 2003
Last modified: July 9, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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