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Protein

Methionyl-tRNA formyltransferase

Gene

fmt

Organism
Bifidobacterium longum (strain NCC 2705)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.UniRule annotation

Catalytic activityi

10-formyltetrahydrofolate + L-methionyl-tRNA(fMet) = tetrahydrofolate + N-formylmethionyl-tRNA(fMet).UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferase
Biological processProtein biosynthesis

Enzyme and pathway databases

BioCyciBLON206672:G1FZZ-1819-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Methionyl-tRNA formyltransferaseUniRule annotation (EC:2.1.2.9UniRule annotation)
Gene namesi
Name:fmtUniRule annotation
Ordered Locus Names:BL1789
OrganismiBifidobacterium longum (strain NCC 2705)
Taxonomic identifieri206672 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000000439 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000829231 – 328Methionyl-tRNA formyltransferaseAdd BLAST328

Interactioni

Protein-protein interaction databases

STRINGi206672.BL1789

Structurei

3D structure databases

ProteinModelPortaliQ8G3H1
SMRiQ8G3H1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 113Tetrahydrofolate (THF) bindingUniRule annotation4

Sequence similaritiesi

Belongs to the Fmt family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CAE Bacteria
COG0223 LUCA
HOGENOMiHOG000261177
KOiK00604
OMAiLRIVFMG
PhylomeDBiQ8G3H1

Family and domain databases

Gene3Di3.10.25.10, 1 hit
HAMAPiMF_00182 Formyl_trans, 1 hit
InterProiView protein in InterPro
IPR005794 Fmt
IPR005793 Formyl_trans_C
IPR037022 Formyl_trans_C_sf
IPR002376 Formyl_transf_N
IPR036477 Formyl_transf_N_sf
IPR011034 Formyl_transferase-like_C_sf
PfamiView protein in Pfam
PF02911 Formyl_trans_C, 1 hit
PF00551 Formyl_trans_N, 1 hit
SUPFAMiSSF50486 SSF50486, 1 hit
SSF53328 SSF53328, 1 hit
TIGRFAMsiTIGR00460 fmt, 1 hit

Sequencei

Sequence statusi: Complete.

Q8G3H1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKLVFAGTP DVAVPSLKAF AADPRFDVVG VITRPDAPTG RGRKLTPSPV
60 70 80 90 100
KATALELGLP VIDLKPRSPE FMEALNNLHA DIAAVIAYGN ILPKNVLDAV
110 120 130 140 150
PMGWYNLHFS NLPKWRGAAP AQRAIWAGDP TTGADVFKVG EGLDDGPIVA
160 170 180 190 200
SLTIELTGRE TSGELLDRLA EEGAPMYVDA LAAVGEGTAT FTAQPAEGLE
210 220 230 240 250
YAHKITVEDA RISWTDEAEA IDRQVRACTP HPGAWTELFA EGPIADNDEP
260 270 280 290 300
AAKPLTLHIL AAQPADQSNP NTPAELQPGE LKVGKKNVWV GTGSTPLELT
310 320
QVKAQGKKAM RAADWARGAR LSPAACVR
Length:328
Mass (Da):34,765
Last modified:March 1, 2003 - v1
Checksum:iC82757C165D55361
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014295 Genomic DNA Translation: AAN25572.1
RefSeqiNP_696936.1, NC_004307.2
WP_007053160.1, NC_004307.2

Genome annotation databases

EnsemblBacteriaiAAN25572; AAN25572; BL1789
GeneIDi1022106
KEGGiblo:BL1789
PATRICifig|206672.9.peg.1842

Entry informationi

Entry nameiFMT_BIFLO
AccessioniPrimary (citable) accession number: Q8G3H1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: March 1, 2003
Last modified: March 28, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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