Chromosomal replication initiator protein dnaA - Brucella suis

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Reviewed, UniProtKB/Swiss-Prot Q8G3E7 (DNAA_BRUSU)

Last modified November 24, 2009. Version 44. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
Chromosomal replication initiator protein dnaA

Gene names

Name:	dnaA
Ordered Locus Names:	BR0001

Organism

Brucella suis [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dnaA family.

Ontologies

Keywords
Biological process	DNA replication
Cellular component	Cytoplasm
Ligand	ATP-binding DNA-binding Nucleotide-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication initiation Inferred from electronic annotation. Source: HAMAP regulation of DNA replication Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP DNA replication origin binding Inferred from electronic annotation. Source: HAMAP nucleoside-triphosphatase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

496

Chromosomal replication initiator protein dnaA HAMAP MF_00377

PRO_0000114147

Regions

Nucleotide binding

8

ATP Potential

Sequences

Sequence

Length

Mass (Da)

Tools

Q8G3E7-1 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 78ABDFC13298A0AA
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496

55,179

        10         20         30         40         50         60 
MKMDSAVSEE AFERLTAKLK ARVGGEIYSS WFGRLKLDDI SKSIVRLSVP TAFLRSWINN 

        70         80         90        100        110        120 
HYSELLTELW QEENPQILKV EVVVRGVSRV VRSAAPAETC DNAEAKPAVT PREKMVFPVG 

       130        140        150        160        170        180 
QSFGGQSLGE KRGSAVVAES AAATDAVLGS PLDPRYTFDT FVDGASNRVA LAAARTIAEA 

       190        200        210        220        230        240 
GSSAVRFNPL FIHASVGLGK THLLQAIAAA ALQRQEKARV VYLTAEYFMW RFATAIRDNN 

       250        260        270        280        290        300 
ALSFKEQLRD IDLLVIDDMQ FLQGKSIQHE FCHLLNTLLD SAKQVVVAAD RAPSELESLD 

       310        320        330        340        350        360 
VRVRSRLQGG VALEVAAPDY EMRLEMLRRR LASAQCEDAS LDIGEEILAH VARTVTGSGR 

       370        380        390        400        410        420 
ELEGAFNQLL FRQSFEPNIS IDRVDELLGH LTRAGEPKRI RIEEIQRIVA RHYNVSKQDL 

       430        440        450        460        470        480 
LSNRRTRTIV KPRQVAMYLA KMMTPRSLPE IGRRFGGRDH TTVLHAVRKI EDLVGADTKL 

       490 
AQELELLKRL INDQAA

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M.

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Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330 / Biovar 1.

Cross-references

Sequence databases
	AE014291 Genomic DNA. Translation: AAN28959.1.
RefSeq	NP_697044.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1165657.
GenomeReviews	Gene locus BR0001 in contig AE014291_GR.
KEGG	bms:BR0001.
NMPDR	fig\|204722.1.peg.1.
TIGR	BR0001.
Phylogenomic databases
HOGENOM	Q8G3E7.
OMA	CHTLNAL
Enzyme and pathway databases
BioCyc	BSUI204722:BR_0001-MON.
Family and domain databases
HAMAP	MF_00377. [Tree]
InterPro	IPR003593. ATPase_AAA+_core. IPR001957. Chromosome_initiator_DnaA. IPR020591. Chromosome_initiator_DnaA-like. IPR018312. Chromosome_initiator_DnaA_CS. IPR013159. DnaA_C. IPR013317. DnaA_Hda. IPR010921. Trp_repressor/repl_initiator. [Graphical view]
Pfam	PF00308. Bac_DnaA. 1 hit. PF08299. Bac_DnaA_C. 1 hit. [Graphical view]
PRINTS	PR00051. DNAA.
SMART	SM00382. AAA. 1 hit. SM00760. Bac_DnaA_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00362. DnaA. 1 hit.
PROSITE	PS01008. DNAA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DNAA_BRUSU

Accession

Primary (citable) accession number: Q8G3E7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	March 1, 2003
Last modified:	November 24, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

Brucella suis (strain 1330): entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents