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Q8G3B2

- KDSB_BRUSU

UniProt

Q8G3B2 - KDSB_BRUSU

Protein

3-deoxy-manno-octulosonate cytidylyltransferase

Gene

kdsB

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.UniRule annotation

    Catalytic activityi

    CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 3-deoxy-manno-octulosonate cytidylyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. CMP-keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-UniPathway
    2. keto-3-deoxy-D-manno-octulosonic acid biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipopolysaccharide biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00030.
    UPA00358; UER00476.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-deoxy-manno-octulosonate cytidylyltransferaseUniRule annotation (EC:2.7.7.38UniRule annotation)
    Alternative name(s):
    CMP-2-keto-3-deoxyoctulosonic acid synthaseUniRule annotation
    Short name:
    CKSUniRule annotation
    Short name:
    CMP-KDO synthaseUniRule annotation
    Gene namesi
    Name:kdsBUniRule annotation
    Ordered Locus Names:BR0038, BS1330_I0038
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2512513-deoxy-manno-octulosonate cytidylyltransferasePRO_0000370017Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BR0038.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G3B2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the KdsB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1212.
    HOGENOMiHOG000007602.
    KOiK00979.
    OMAiDDQRIAD.
    OrthoDBiEOG6KT2SK.

    Family and domain databases

    Gene3Di3.90.550.10. 1 hit.
    HAMAPiMF_00057. CMP_KDO_synth.
    InterProiIPR003329. Cytidylyl_trans.
    IPR004528. KdsB.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR21485:SF4. PTHR21485:SF4. 1 hit.
    PfamiPF02348. CTP_transf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF53448. SSF53448. 1 hit.
    TIGRFAMsiTIGR00466. kdsB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8G3B2-1 [UniParc]FASTAAdd to Basket

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    MLQTMKTLTL IPTRLGSTRL PNKPLADICG KPMIVHVADR AAAAKLGRTV    50
    IATDSEEIFK VVAAHGHEAI MTRGDHESGS DRIYEALAKL DPSGEIDAVV 100
    NVQGDLPTID PDTIRRALLP LEDGPADIAT LGVEITVEEE KTNPNVVKIV 150
    GSPLAGNRRL RALYFTRATA PYGEGPLYHH IGLYAYRRSA LERFVKLGPS 200
    PLEKREKLEQ LRALEAGMRI DVEIVKTVPL GVDTQADLDR ARTFCSQAGT 250
    I 251
    Length:251
    Mass (Da):27,334
    Last modified:March 1, 2003 - v1
    Checksum:i8EFDB1A32037C2B6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN28995.1.
    CP002997 Genomic DNA. Translation: AEM17407.1.
    RefSeqiNP_697080.1. NC_004310.3.
    YP_005614899.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN28995; AAN28995; BR0038.
    AEM17407; AEM17407; BS1330_I0038.
    GeneIDi1165695.
    12137252.
    KEGGibms:BR0038.
    bsi:BS1330_I0038.
    PATRICi17788337. VBIBruSui107850_0042.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN28995.1 .
    CP002997 Genomic DNA. Translation: AEM17407.1 .
    RefSeqi NP_697080.1. NC_004310.3.
    YP_005614899.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G3B2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN28995 ; AAN28995 ; BR0038 .
    AEM17407 ; AEM17407 ; BS1330_I0038 .
    GeneIDi 1165695.
    12137252.
    KEGGi bms:BR0038.
    bsi:BS1330_I0038.
    PATRICi 17788337. VBIBruSui107850_0042.

    Phylogenomic databases

    eggNOGi COG1212.
    HOGENOMi HOG000007602.
    KOi K00979.
    OMAi DDQRIAD.
    OrthoDBi EOG6KT2SK.

    Enzyme and pathway databases

    UniPathwayi UPA00030 .
    UPA00358 ; UER00476 .

    Family and domain databases

    Gene3Di 3.90.550.10. 1 hit.
    HAMAPi MF_00057. CMP_KDO_synth.
    InterProi IPR003329. Cytidylyl_trans.
    IPR004528. KdsB.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR21485:SF4. PTHR21485:SF4. 1 hit.
    Pfami PF02348. CTP_transf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53448. SSF53448. 1 hit.
    TIGRFAMsi TIGR00466. kdsB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiKDSB_BRUSU
    AccessioniPrimary (citable) accession number: Q8G3B2
    Secondary accession number(s): G0KAL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3