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Protein

Protein GrpE

Gene

grpE

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Stress response

Names & Taxonomyi

Protein namesi
Recommended name:
Protein GrpEUniRule annotation
Alternative name(s):
HSP-70 cofactorUniRule annotation
Gene namesi
Name:grpEUniRule annotation
Ordered Locus Names:BR0171, BS1330_I0171
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 230230Protein GrpEPRO_0000113756Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8G2Y6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GrpE family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0576.
HOGENOMiHOG000252083.
KOiK03687.
OMAiQKACACK.
OrthoDBiEOG6FJNJ9.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G2Y6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEKNKPEN PDLDQRDINN PRDREALKQA ADDFLKARRA EARAEAAADE
60 70 80 90 100
AEGEVDETAN RIAVLEADNT ELKDQMLRVA AEMENLRKRT QRDVQDARAY
110 120 130 140 150
AITNFARDML SVSDNLRRAL DAIPADALEA DSNLKSLSEG VEMTERAMLL
160 170 180 190 200
ALERHGVKKL EPEGQKFDPN FHQAMFEVPN PDLPNNTVVQ VVQAGYAIGD
210 220 230
RVLRPAMVGV SKGGPKVSAE NGASTSEDNA
Length:230
Mass (Da):25,310
Last modified:March 1, 2003 - v1
Checksum:iC6A377466434FC11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29124.1.
CP002997 Genomic DNA. Translation: AEM17536.1.
RefSeqiNP_697209.1. NC_004310.3.
WP_004685378.1. NZ_KN046804.1.
YP_005615028.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29124; AAN29124; BR0171.
AEM17536; AEM17536; BS1330_I0171.
KEGGibms:BR0171.
bsi:BS1330_I0171.
PATRICi17788610. VBIBruSui107850_0178.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29124.1.
CP002997 Genomic DNA. Translation: AEM17536.1.
RefSeqiNP_697209.1. NC_004310.3.
WP_004685378.1. NZ_KN046804.1.
YP_005615028.1. NC_017251.1.

3D structure databases

ProteinModelPortaliQ8G2Y6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN29124; AAN29124; BR0171.
AEM17536; AEM17536; BS1330_I0171.
KEGGibms:BR0171.
bsi:BS1330_I0171.
PATRICi17788610. VBIBruSui107850_0178.

Phylogenomic databases

eggNOGiCOG0576.
HOGENOMiHOG000252083.
KOiK03687.
OMAiQKACACK.
OrthoDBiEOG6FJNJ9.

Family and domain databases

Gene3Di2.30.22.10. 1 hit.
3.90.20.20. 1 hit.
HAMAPiMF_01151. GrpE.
InterProiIPR000740. GrpE.
IPR013805. GrpE_coiled_coil.
IPR009012. GrpE_head.
[Graphical view]
PANTHERiPTHR21237. PTHR21237. 1 hit.
PfamiPF01025. GrpE. 1 hit.
[Graphical view]
PRINTSiPR00773. GRPEPROTEIN.
SUPFAMiSSF51064. SSF51064. 1 hit.
PROSITEiPS01071. GRPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiGRPE_BRUSU
AccessioniPrimary (citable) accession number: Q8G2Y6
Secondary accession number(s): G0KBE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.