Reviewed, UniProtKB/Swiss-Prot Q8G2U9 (THIG_BRUSU)

Names and origin

Protein names

Recommended name:
    Thiazole biosynthesis protein thiG

Gene names

Name:	thiG
Ordered Locus Names:	BR0215

Organism

Brucella suis [Complete proteome] [HAMAP]

Taxonomic identifier

29461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Required for the synthesis of the thiazole moiety of thiamine By similarity.
Cofactor	FMN Potential.
Pathway	Cofactor biosynthesis; thiamine diphosphate biosynthesis. HAMAP MF_00443
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the thiG family.

Ontologies

Keywords
Biological process	Thiamine biosynthesis
Cellular component	Cytoplasm
Ligand	FMN Flavoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	thiamin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Thiazole biosynthesis protein thiG HAMAP MF_00443		PRO_0000162798

Sequences

	Sequence		Length	Mass (Da)
	Q8G2U9-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: B4BB14EEA3EA18D0	FASTA	256	27,351
	10 20 30 40 50 60 MLEFYGKRFE SRLLLGTAQY PSPSILADAV RASLSRIVTV SLRRESGEAR AGQDFWALIK 70 80 90 100 110 120 ALGVAVLPNT AGCHTPREAI TTAHMAREVF GTNWIKLEVI GDTDTLQPDP FGLVEAARIL 130 140 150 160 170 180 CDESFEVFPY MNDDLIVAER LIEAGCKVLM PWGAPIGSGR GLNNPYALKT MRAHFPDIPL 190 200 210 220 230 240 VVDAGIGVPS HAAAAMELGF DAVLINTAVA KAGDPAAMAR AFALAVEAGR LAYEADPIEA 250 RDMASPSTPL LGKAFL

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014291 Genomic DNA. Translation: AAN29164.1.
RefSeq	NP_697249.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1165873.
GenomeReviews	Gene locus BR0215 in contig AE014291_GR.
KEGG	bms:BR0215.
NMPDR	fig|204722.1.peg.206.
TIGR	BR0215.
Phylogenomic databases
HOGENOM	Q8G2U9.
OMA	VAIRRTN
Enzyme and pathway databases
BioCyc	BSUI204722:BR_0215-MON.
Family and domain databases
HAMAP	MF_00443. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR008867. ThiG. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
Pfam	PF05690. ThiG. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIG_BRUSU

Accession

Primary (citable) accession number: Q8G2U9

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 16, 2003
Last sequence update:	March 1, 2003
Last modified:	November 24, 2009
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)