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Q8G2Q1

- URED1_BRUSU

UniProt

Q8G2Q1 - URED1_BRUSU

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Protein
Urease accessory protein UreD 1
Gene
ureD1, ureD-1, BR0267, BS1330_I0268
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter By similarity.1 Publication
Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when innoculated in BALB/c mice by gavage.1 Publication

GO - Molecular functioni

  1. nickel cation binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. nitrogen compound metabolic process Source: InterPro
  2. pathogenesis Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Nickel insertion, Virulence

Names & Taxonomyi

Protein namesi
Recommended name:
Urease accessory protein UreD 1
Gene namesi
Name:ureD1
Synonyms:ureD-1
Ordered Locus Names:BR0267, BS1330_I0268
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Urease accessory protein UreD 1UniRule annotation
PRO_0000340427Add
BLAST

Interactioni

Subunit structurei

UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel By similarity.

Protein-protein interaction databases

STRINGi204722.BR0267.

Family & Domainsi

Sequence similaritiesi

Belongs to the UreD family.

Phylogenomic databases

eggNOGiCOG0829.
HOGENOMiHOG000263489.
KOiK03190.
OMAiILFDRAR.
OrthoDBiEOG6W9X5J.

Family and domain databases

HAMAPiMF_01384. UreD.
InterProiIPR002669. UreD.
[Graphical view]
PfamiPF01774. UreD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G2Q1-1 [UniParc]FASTAAdd to Basket

« Hide

MLIINDNNLS GLSLQRVNGT GELSVQFKDG RSRISRLYQE GAAKIRMPQA    50
VTGPLEAILI NTSGGLTGGD RLKWDVALDD GASAVITTQA CERIYRSGGG 100
EARIATRLKA AKGTRLAWLP QETILFNRSI LSRRLDVELE EGAQMLVVEA 150
TVFGRLAMGE RVVAARFADR WRVRLGGRVI HAEEFRLGPD VGAELQAPAV 200
AGGACAMATV LMVCEQAGRH LETARAIIGE EGGCSLWRVG KASKLVVRLY 250
APDSYALRRR LCPLVALLNG KAGLPKVWTI 280
Length:280
Mass (Da):30,230
Last modified:March 1, 2003 - v1
Checksum:i2555CA77107D953D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29216.1.
CP002997 Genomic DNA. Translation: AEM17629.1.
RefSeqiNP_697301.1. NC_004310.3.
YP_005615121.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29216; AAN29216; BR0267.
AEM17629; AEM17629; BS1330_I0268.
GeneIDi1165927.
12136586.
KEGGibms:BR0267.
bsi:BS1330_I0268.
PATRICi17788821. VBIBruSui107850_0280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29216.1 .
CP002997 Genomic DNA. Translation: AEM17629.1 .
RefSeqi NP_697301.1. NC_004310.3.
YP_005615121.1. NC_017251.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0267.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29216 ; AAN29216 ; BR0267 .
AEM17629 ; AEM17629 ; BS1330_I0268 .
GeneIDi 1165927.
12136586.
KEGGi bms:BR0267.
bsi:BS1330_I0268.
PATRICi 17788821. VBIBruSui107850_0280.

Phylogenomic databases

eggNOGi COG0829.
HOGENOMi HOG000263489.
KOi K03190.
OMAi ILFDRAR.
OrthoDBi EOG6W9X5J.

Family and domain databases

HAMAPi MF_01384. UreD.
InterProi IPR002669. UreD.
[Graphical view ]
Pfami PF01774. UreD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. "Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice."
    Bandara A.B., Contreras A., Contreras-Rodriguez A., Martins A.M., Dobrean V., Poff-Reichow S., Rajasekaran P., Sriranganathan N., Schurig G.G., Boyle S.M.
    BMC Microbiol. 7:57-57(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: OPERON DISRUPTION, ROLE IN VIRULENCE.
    Strain: 1330.

Entry informationi

Entry nameiURED1_BRUSU
AccessioniPrimary (citable) accession number: Q8G2Q1
Secondary accession number(s): G0KBW6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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