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Q8G2Q1

- URED1_BRUSU

UniProt

Q8G2Q1 - URED1_BRUSU

Protein

Urease accessory protein UreD 1

Gene

ureD1

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.UniRule annotation
    Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when innoculated in BALB/c mice by gavage.1 Publication

    GO - Molecular functioni

    1. nickel cation binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. nitrogen compound metabolic process Source: InterPro
    2. pathogenesis Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chaperone

    Keywords - Biological processi

    Nickel insertion, Virulence

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urease accessory protein UreD 1UniRule annotation
    Gene namesi
    Name:ureD1UniRule annotation
    Synonyms:ureD-1
    Ordered Locus Names:BR0267, BS1330_I0268
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Urease accessory protein UreD 1PRO_0000340427Add
    BLAST

    Interactioni

    Subunit structurei

    UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR0267.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the UreD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0829.
    HOGENOMiHOG000263489.
    KOiK03190.
    OMAiILFDRAR.
    OrthoDBiEOG6W9X5J.

    Family and domain databases

    HAMAPiMF_01384. UreD.
    InterProiIPR002669. UreD.
    [Graphical view]
    PfamiPF01774. UreD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G2Q1-1 [UniParc]FASTAAdd to Basket

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    MLIINDNNLS GLSLQRVNGT GELSVQFKDG RSRISRLYQE GAAKIRMPQA    50
    VTGPLEAILI NTSGGLTGGD RLKWDVALDD GASAVITTQA CERIYRSGGG 100
    EARIATRLKA AKGTRLAWLP QETILFNRSI LSRRLDVELE EGAQMLVVEA 150
    TVFGRLAMGE RVVAARFADR WRVRLGGRVI HAEEFRLGPD VGAELQAPAV 200
    AGGACAMATV LMVCEQAGRH LETARAIIGE EGGCSLWRVG KASKLVVRLY 250
    APDSYALRRR LCPLVALLNG KAGLPKVWTI 280
    Length:280
    Mass (Da):30,230
    Last modified:March 1, 2003 - v1
    Checksum:i2555CA77107D953D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29216.1.
    CP002997 Genomic DNA. Translation: AEM17629.1.
    RefSeqiNP_697301.1. NC_004310.3.
    YP_005615121.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29216; AAN29216; BR0267.
    AEM17629; AEM17629; BS1330_I0268.
    GeneIDi1165927.
    12136586.
    KEGGibms:BR0267.
    bsi:BS1330_I0268.
    PATRICi17788821. VBIBruSui107850_0280.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29216.1 .
    CP002997 Genomic DNA. Translation: AEM17629.1 .
    RefSeqi NP_697301.1. NC_004310.3.
    YP_005615121.1. NC_017251.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0267.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29216 ; AAN29216 ; BR0267 .
    AEM17629 ; AEM17629 ; BS1330_I0268 .
    GeneIDi 1165927.
    12136586.
    KEGGi bms:BR0267.
    bsi:BS1330_I0268.
    PATRICi 17788821. VBIBruSui107850_0280.

    Phylogenomic databases

    eggNOGi COG0829.
    HOGENOMi HOG000263489.
    KOi K03190.
    OMAi ILFDRAR.
    OrthoDBi EOG6W9X5J.

    Family and domain databases

    HAMAPi MF_01384. UreD.
    InterProi IPR002669. UreD.
    [Graphical view ]
    Pfami PF01774. UreD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    3. "Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice."
      Bandara A.B., Contreras A., Contreras-Rodriguez A., Martins A.M., Dobrean V., Poff-Reichow S., Rajasekaran P., Sriranganathan N., Schurig G.G., Boyle S.M.
      BMC Microbiol. 7:57-57(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: OPERON DISRUPTION, ROLE IN VIRULENCE.
      Strain: 1330.

    Entry informationi

    Entry nameiURED1_BRUSU
    AccessioniPrimary (citable) accession number: Q8G2Q1
    Secondary accession number(s): G0KBW6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3