Reviewed,
UniProtKB/Swiss-Prot Q8G2Q0 (URE31_BRUSU)
Last modified
November 24, 2009.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Urease subunit gamma 1 EC=3.5.1.5 Alternative name(s): Urea amidohydrolase subunit gamma 1 | ||||||
| Gene names |
| ||||||
| Organism | Brucella suis [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 29461 [NCBI] | ||||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 100 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when innoculated in BALB/c mice by gavage. Ref.2 |
| Catalytic activity | Urea + H2O = CO2 + 2 NH3. HAMAP MF_00739 |
| Pathway | Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP MF_00739 |
| Subunit structure | Heterotrimer of ureA (gamma), ureB (beta) and ureC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the urease gamma subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Virulence |
| Cellular component | Cytoplasm |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | pathogenesis Inferred from electronic annotation. Source: UniProtKB-KW urea metabolic processInferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | nickel ion binding Inferred from electronic annotation. Source: InterPro urease activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 100 | 100 | Urease subunit gamma 1 HAMAP MF_00739 | PRO_0000098003 | |||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. Fraser C.M.Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1. |
| [2] | "Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice." Bandara A.B., Contreras A., Contreras-Rodriguez A., Martins A.M., Dobrean V., Poff-Reichow S., Rajasekaran P., Sriranganathan N., Schurig G.G., Boyle S.M. BMC Microbiol. 7:57-57(2007) [PubMed: 17578575] [Abstract] Cited for: CHARACTERIZATION OF ROLE IN VIRULENCE, OPERON DISRUPTION. Strain: 1330 / Biovar 1. |
Cross-references
Sequence databases | |
|---|---|
| AE014291 Genomic DNA. Translation: AAN29217.1. | |
| RefSeq | NP_697302.1. |
3D structure databases | |
| SMR | Q8G2Q0. Positions 1-99. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1165928. |
| GenomeReviews | Gene locus BR0268 in contig AE014291_GR. |
| KEGG | bms:BR0268. |
| NMPDR | fig|204722.1.peg.259. |
| TIGR | BR0268. |
Phylogenomic databases | |
| HOGENOM | Q8G2Q0. |
| OMA | EAIAIIS |
Enzyme and pathway databases | |
| BioCyc | BSUI204722:BR_0268-MON. |
| BRENDA | 3.5.1.5. 281610. |
Family and domain databases | |
| HAMAP | MF_00739. [Tree] |
| InterPro | IPR002026. Urease_alpha/gamma. IPR012010. Urease_gamma. [Graphical view] |
| Gene3D | G3DSA:3.30.280.10. Urease_gamma_reg. 1 hit. |
| Pfam | PF00547. Urease_gamma. 1 hit. [Graphical view] |
| PIRSF | PIRSF001223. Urease_gamma. 1 hit. |
| ProDom | PD002319. Urease_gamma_reg. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00193. urease_gam. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | URE31_BRUSU | ||||||||
| Accession | Primary (citable) accession number: Q8G2Q0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella suis Brucella suis (strain 1330): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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