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Q8G2Q0

- URE31_BRUSU

UniProt

Q8G2Q0 - URE31_BRUSU

Protein

Urease subunit gamma 1

Gene

ureA1

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when innoculated in BALB/c mice by gavage.

    Catalytic activityi

    Urea + H2O = CO2 + 2 NH3.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. nickel cation binding Source: InterPro
    2. urease activity Source: UniProtKB-EC

    GO - Biological processi

    1. pathogenesis Source: UniProtKB-KW
    2. urea catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Virulence

    Enzyme and pathway databases

    UniPathwayiUPA00258; UER00370.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Urease subunit gamma 1UniRule annotation (EC:3.5.1.5UniRule annotation)
    Alternative name(s):
    Urea amidohydrolase subunit gamma 1UniRule annotation
    Gene namesi
    Name:ureA1UniRule annotation
    Synonyms:ureA-1
    Ordered Locus Names:BR0268, BS1330_I0269
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 100100Urease subunit gamma 1PRO_0000098003Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR0268.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G2Q0.
    SMRiQ8G2Q0. Positions 1-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the urease gamma subunit family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0831.
    HOGENOMiHOG000075053.
    KOiK01430.
    OMAiHVITRDQ.
    OrthoDBiEOG69PQ9G.

    Family and domain databases

    Gene3Di3.30.280.10. 1 hit.
    HAMAPiMF_00739. Urease_gamma.
    InterProiIPR012010. Urease_gamma.
    IPR002026. Urease_gamma/gamma-beta_su.
    [Graphical view]
    PfamiPF00547. Urease_gamma. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001223. Urease_gamma. 1 hit.
    ProDomiPD002319. Urease_gamma_reg. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF54111. SSF54111. 1 hit.
    TIGRFAMsiTIGR00193. urease_gam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8G2Q0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNLTPREKDK LLIAMAAMVA RRRLERGVKL NHPEAIALVS DFVVEGARDG    50
    RTVAELMEAG AYVITREQVM DGVAEMIRDI QVEATFPDGT KLVTVHEPIR 100
    Length:100
    Mass (Da):11,129
    Last modified:March 1, 2003 - v1
    Checksum:i6CFFAAE9739604FB
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29217.1.
    CP002997 Genomic DNA. Translation: AEM17630.1.
    RefSeqiNP_697302.1. NC_004310.3.
    YP_005615122.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29217; AAN29217; BR0268.
    AEM17630; AEM17630; BS1330_I0269.
    GeneIDi1165928.
    12136587.
    KEGGibms:BR0268.
    bsi:BS1330_I0269.
    PATRICi17788823. VBIBruSui107850_0281.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29217.1 .
    CP002997 Genomic DNA. Translation: AEM17630.1 .
    RefSeqi NP_697302.1. NC_004310.3.
    YP_005615122.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G2Q0.
    SMRi Q8G2Q0. Positions 1-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0268.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29217 ; AAN29217 ; BR0268 .
    AEM17630 ; AEM17630 ; BS1330_I0269 .
    GeneIDi 1165928.
    12136587.
    KEGGi bms:BR0268.
    bsi:BS1330_I0269.
    PATRICi 17788823. VBIBruSui107850_0281.

    Phylogenomic databases

    eggNOGi COG0831.
    HOGENOMi HOG000075053.
    KOi K01430.
    OMAi HVITRDQ.
    OrthoDBi EOG69PQ9G.

    Enzyme and pathway databases

    UniPathwayi UPA00258 ; UER00370 .

    Family and domain databases

    Gene3Di 3.30.280.10. 1 hit.
    HAMAPi MF_00739. Urease_gamma.
    InterProi IPR012010. Urease_gamma.
    IPR002026. Urease_gamma/gamma-beta_su.
    [Graphical view ]
    Pfami PF00547. Urease_gamma. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001223. Urease_gamma. 1 hit.
    ProDomi PD002319. Urease_gamma_reg. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF54111. SSF54111. 1 hit.
    TIGRFAMsi TIGR00193. urease_gam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    3. "Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice."
      Bandara A.B., Contreras A., Contreras-Rodriguez A., Martins A.M., Dobrean V., Poff-Reichow S., Rajasekaran P., Sriranganathan N., Schurig G.G., Boyle S.M.
      BMC Microbiol. 7:57-57(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION OF ROLE IN VIRULENCE, OPERON DISRUPTION.
      Strain: 1330.

    Entry informationi

    Entry nameiURE31_BRUSU
    AccessioniPrimary (citable) accession number: Q8G2Q0
    Secondary accession number(s): G0KBW7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3