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Q8G2Q0

- URE31_BRUSU

UniProt

Q8G2Q0 - URE31_BRUSU

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Protein

Urease subunit gamma 1

Gene

ureA1

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when innoculated in BALB/c mice by gavage.

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. nickel cation binding Source: InterPro
  2. urease activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. urea catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Virulence

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit gamma 1UniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit gamma 1UniRule annotation
Gene namesi
Name:ureA1UniRule annotation
Synonyms:ureA-1
Ordered Locus Names:BR0268, BS1330_I0269
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100100Urease subunit gamma 1PRO_0000098003Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR0268.

Structurei

3D structure databases

ProteinModelPortaliQ8G2Q0.
SMRiQ8G2Q0. Positions 1-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease gamma subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0831.
HOGENOMiHOG000075053.
KOiK01430.
OMAiHVITRDQ.
OrthoDBiEOG69PQ9G.

Family and domain databases

Gene3Di3.30.280.10. 1 hit.
HAMAPiMF_00739. Urease_gamma.
InterProiIPR012010. Urease_gamma.
IPR002026. Urease_gamma/gamma-beta_su.
[Graphical view]
PfamiPF00547. Urease_gamma. 1 hit.
[Graphical view]
PIRSFiPIRSF001223. Urease_gamma. 1 hit.
ProDomiPD002319. Urease_gamma_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF54111. SSF54111. 1 hit.
TIGRFAMsiTIGR00193. urease_gam. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G2Q0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLTPREKDK LLIAMAAMVA RRRLERGVKL NHPEAIALVS DFVVEGARDG
60 70 80 90 100
RTVAELMEAG AYVITREQVM DGVAEMIRDI QVEATFPDGT KLVTVHEPIR
Length:100
Mass (Da):11,129
Last modified:March 1, 2003 - v1
Checksum:i6CFFAAE9739604FB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29217.1.
CP002997 Genomic DNA. Translation: AEM17630.1.
RefSeqiNP_697302.1. NC_004310.3.
YP_005615122.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29217; AAN29217; BR0268.
AEM17630; AEM17630; BS1330_I0269.
GeneIDi1165928.
12136587.
KEGGibms:BR0268.
bsi:BS1330_I0269.
PATRICi17788823. VBIBruSui107850_0281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29217.1 .
CP002997 Genomic DNA. Translation: AEM17630.1 .
RefSeqi NP_697302.1. NC_004310.3.
YP_005615122.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G2Q0.
SMRi Q8G2Q0. Positions 1-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0268.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29217 ; AAN29217 ; BR0268 .
AEM17630 ; AEM17630 ; BS1330_I0269 .
GeneIDi 1165928.
12136587.
KEGGi bms:BR0268.
bsi:BS1330_I0269.
PATRICi 17788823. VBIBruSui107850_0281.

Phylogenomic databases

eggNOGi COG0831.
HOGENOMi HOG000075053.
KOi K01430.
OMAi HVITRDQ.
OrthoDBi EOG69PQ9G.

Enzyme and pathway databases

UniPathwayi UPA00258 ; UER00370 .

Family and domain databases

Gene3Di 3.30.280.10. 1 hit.
HAMAPi MF_00739. Urease_gamma.
InterProi IPR012010. Urease_gamma.
IPR002026. Urease_gamma/gamma-beta_su.
[Graphical view ]
Pfami PF00547. Urease_gamma. 1 hit.
[Graphical view ]
PIRSFi PIRSF001223. Urease_gamma. 1 hit.
ProDomi PD002319. Urease_gamma_reg. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF54111. SSF54111. 1 hit.
TIGRFAMsi TIGR00193. urease_gam. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. "Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice."
    Bandara A.B., Contreras A., Contreras-Rodriguez A., Martins A.M., Dobrean V., Poff-Reichow S., Rajasekaran P., Sriranganathan N., Schurig G.G., Boyle S.M.
    BMC Microbiol. 7:57-57(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ROLE IN VIRULENCE, OPERON DISRUPTION.
    Strain: 1330.

Entry informationi

Entry nameiURE31_BRUSU
AccessioniPrimary (citable) accession number: Q8G2Q0
Secondary accession number(s): G0KBW7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3