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Q8G2Q0 (URE31_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urease subunit gamma 1

EC=3.5.1.5
Alternative name(s):
Urea amidohydrolase subunit gamma 1
Gene names
Name:ureA1
Synonyms:ureA-1
Ordered Locus Names:BR0268, BS1330_I0269
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length100 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when innoculated in BALB/c mice by gavage. Ref.3

Catalytic activity

Urea + H2O = CO2 + 2 NH3. HAMAP-Rule MF_00739

Pathway

Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP-Rule MF_00739

Subunit structure

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00739.

Sequence similarities

Belongs to the urease gamma subunit family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

urea catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionnickel cation binding

Inferred from electronic annotation. Source: InterPro

urease activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 100100Urease subunit gamma 1 HAMAP-Rule MF_00739
PRO_0000098003

Sequences

Sequence LengthMass (Da)Tools
Q8G2Q0 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 6CFFAAE9739604FB

FASTA10011,129
        10         20         30         40         50         60 
MNLTPREKDK LLIAMAAMVA RRRLERGVKL NHPEAIALVS DFVVEGARDG RTVAELMEAG 

        70         80         90        100 
AYVITREQVM DGVAEMIRDI QVEATFPDGT KLVTVHEPIR 

« Hide

References

« Hide 'large scale' references
[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[3]"Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice."
Bandara A.B., Contreras A., Contreras-Rodriguez A., Martins A.M., Dobrean V., Poff-Reichow S., Rajasekaran P., Sriranganathan N., Schurig G.G., Boyle S.M.
BMC Microbiol. 7:57-57(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF ROLE IN VIRULENCE, OPERON DISRUPTION.
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN29217.1.
CP002997 Genomic DNA. Translation: AEM17630.1.
RefSeqNP_697302.1. NC_004310.3.
YP_005615122.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G2Q0.
SMRQ8G2Q0. Positions 1-99.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR0268.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN29217; AAN29217; BR0268.
AEM17630; AEM17630; BS1330_I0269.
GeneID1165928.
12136587.
KEGGbms:BR0268.
bsi:BS1330_I0269.
PATRIC17788823. VBIBruSui107850_0281.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0831.
HOGENOMHOG000075053.
KOK01430.
OMAHVITRDQ.
OrthoDBEOG69PQ9G.

Enzyme and pathway databases

UniPathwayUPA00258; UER00370.

Family and domain databases

Gene3D3.30.280.10. 1 hit.
HAMAPMF_00739. Urease_gamma.
InterProIPR002026. Urease_gamma/gamma-beta_su.
IPR012010. Urease_gamma_su.
[Graphical view]
PfamPF00547. Urease_gamma. 1 hit.
[Graphical view]
PIRSFPIRSF001223. Urease_gamma. 1 hit.
ProDomPD002319. Urease_gamma_reg. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMSSF54111. SSF54111. 1 hit.
TIGRFAMsTIGR00193. urease_gam. 1 hit.
ProtoNetSearch...

Entry information

Entry nameURE31_BRUSU
AccessionPrimary (citable) accession number: Q8G2Q0
Secondary accession number(s): G0KBW7
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names