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Q8G2P9

- URE21_BRUSU

UniProt

Q8G2P9 - URE21_BRUSU

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Protein

Urease subunit beta 1

Gene

ureB1

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when innoculated in BALB/c mice by gavage.

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. urease activity Source: UniProtKB-EC

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. urea catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Virulence

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit beta 1UniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit beta 1UniRule annotation
Gene namesi
Name:ureB1UniRule annotation
Ordered Locus Names:BR0269, BS1330_I0270
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Urease subunit beta 1PRO_0000234238Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR0269.

Structurei

3D structure databases

ProteinModelPortaliQ8G2P9.
SMRiQ8G2P9. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease beta subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0832.
HOGENOMiHOG000077770.
KOiK01429.
OMAiYGFRQLV.
OrthoDBiEOG69PQ9G.

Family and domain databases

Gene3Di2.10.150.10. 1 hit.
HAMAPiMF_01954. Urease_beta.
InterProiIPR002019. Urease_beta.
[Graphical view]
PfamiPF00699. Urease_beta. 1 hit.
[Graphical view]
SUPFAMiSSF51278. SSF51278. 1 hit.
TIGRFAMsiTIGR00192. urease_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G2P9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIPGEIITLE GDIELNQGQP TVTMRVANTG DRPIQVGSHF HFYEVNAALS
60 70 80 90 100
FDREKARGQR LDIAAGTAVR FEPGQERDVT LVPIRGHREI YGFRQMIMGK

L
Length:101
Mass (Da):11,337
Last modified:March 1, 2003 - v1
Checksum:iEC6F5DA786479D39
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29218.1.
CP002997 Genomic DNA. Translation: AEM17631.1.
RefSeqiNP_697303.1. NC_004310.3.
YP_005615123.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29218; AAN29218; BR0269.
AEM17631; AEM17631; BS1330_I0270.
GeneIDi1165929.
12136588.
KEGGibms:BR0269.
bsi:BS1330_I0270.
PATRICi17788827. VBIBruSui107850_0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29218.1 .
CP002997 Genomic DNA. Translation: AEM17631.1 .
RefSeqi NP_697303.1. NC_004310.3.
YP_005615123.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G2P9.
SMRi Q8G2P9. Positions 1-101.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0269.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29218 ; AAN29218 ; BR0269 .
AEM17631 ; AEM17631 ; BS1330_I0270 .
GeneIDi 1165929.
12136588.
KEGGi bms:BR0269.
bsi:BS1330_I0270.
PATRICi 17788827. VBIBruSui107850_0283.

Phylogenomic databases

eggNOGi COG0832.
HOGENOMi HOG000077770.
KOi K01429.
OMAi YGFRQLV.
OrthoDBi EOG69PQ9G.

Enzyme and pathway databases

UniPathwayi UPA00258 ; UER00370 .

Family and domain databases

Gene3Di 2.10.150.10. 1 hit.
HAMAPi MF_01954. Urease_beta.
InterProi IPR002019. Urease_beta.
[Graphical view ]
Pfami PF00699. Urease_beta. 1 hit.
[Graphical view ]
SUPFAMi SSF51278. SSF51278. 1 hit.
TIGRFAMsi TIGR00192. urease_beta. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. "Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice."
    Bandara A.B., Contreras A., Contreras-Rodriguez A., Martins A.M., Dobrean V., Poff-Reichow S., Rajasekaran P., Sriranganathan N., Schurig G.G., Boyle S.M.
    BMC Microbiol. 7:57-57(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ROLE IN VIRULENCE, OPERON DISRUPTION.
    Strain: 1330.

Entry informationi

Entry nameiURE21_BRUSU
AccessioniPrimary (citable) accession number: Q8G2P9
Secondary accession number(s): G0KBW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3