Reviewed,
UniProtKB/Swiss-Prot Q8G2P9 (URE21_BRUSU)
Last modified
November 24, 2009.
Version 39.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Urease subunit beta 1 EC=3.5.1.5 Alternative name(s): Urea amidohydrolase subunit beta 1 | ||||
| Gene names |
| ||||
| Organism | Brucella suis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 29461 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 101 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when innoculated in BALB/c mice by gavage. Ref.2 |
| Catalytic activity | Urea + H2O = CO2 + 2 NH3. HAMAP MF_01954 |
| Pathway | Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP MF_01954 |
| Subunit structure | Heterotrimer of ureA (gamma), ureB (beta) and ureC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity. |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the urease beta subunit family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Virulence |
| Cellular component | Cytoplasm |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | nitrogen compound metabolic process Inferred from electronic annotation. Source: InterPro pathogenesisInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | nickel ion binding Inferred from electronic annotation. Source: InterPro urease activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 101 | 101 | Urease subunit beta 1 HAMAP MF_01954 | PRO_0000234238 | |||
Sequences
References
Cross-references
Sequence databases | |
|---|---|
| AE014291 Genomic DNA. Translation: AAN29218.1. | |
| RefSeq | NP_697303.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1165929. |
| GenomeReviews | Gene locus BR0269 in contig AE014291_GR. |
| KEGG | bms:BR0269. |
| TIGR | BR0269. |
Phylogenomic databases | |
| HOGENOM | Q8G2P9. |
| OMA | PGELELN |
Enzyme and pathway databases | |
| BioCyc | BSUI204722:BR_0269-MON. |
| BRENDA | 3.5.1.5. 281610. |
Family and domain databases | |
| HAMAP | MF_01954. [Tree] |
| InterPro | IPR002019. Urease_beta. [Graphical view] |
| Gene3D | G3DSA:2.10.150.10. Urease_beta. 1 hit. |
| Pfam | PF00699. Urease_beta. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00192. urease_beta. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | URE21_BRUSU | ||||||||
| Accession | Primary (citable) accession number: Q8G2P9 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella suis Brucella suis (strain 1330): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


