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Protein

Urease subunit beta 1

Gene

ureB1

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when innoculated in BALB/c mice by gavage.

Catalytic activityi

Urea + H2O = CO2 + 2 NH3.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. urease activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pathogenesis Source: UniProtKB-KW
  2. urea catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Virulence

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Names & Taxonomyi

Protein namesi
Recommended name:
Urease subunit beta 1UniRule annotation (EC:3.5.1.5UniRule annotation)
Alternative name(s):
Urea amidohydrolase subunit beta 1UniRule annotation
Gene namesi
Name:ureB1UniRule annotation
Ordered Locus Names:BR0269, BS1330_I0270
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I UP000000824 Componenti: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 101101Urease subunit beta 1PRO_0000234238Add
BLAST

Interactioni

Subunit structurei

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR0269.

Structurei

3D structure databases

ProteinModelPortaliQ8G2P9.
SMRiQ8G2P9. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the urease beta subunit family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0832.
HOGENOMiHOG000077770.
KOiK01429.
OMAiREVYGFQ.
OrthoDBiEOG69PQ9G.

Family and domain databases

Gene3Di2.10.150.10. 1 hit.
HAMAPiMF_01954. Urease_beta.
InterProiIPR002019. Urease_beta.
[Graphical view]
PfamiPF00699. Urease_beta. 1 hit.
[Graphical view]
SUPFAMiSSF51278. SSF51278. 1 hit.
TIGRFAMsiTIGR00192. urease_beta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G2P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPGEIITLE GDIELNQGQP TVTMRVANTG DRPIQVGSHF HFYEVNAALS
60 70 80 90 100
FDREKARGQR LDIAAGTAVR FEPGQERDVT LVPIRGHREI YGFRQMIMGK

L
Length:101
Mass (Da):11,337
Last modified:February 28, 2003 - v1
Checksum:iEC6F5DA786479D39
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29218.1.
CP002997 Genomic DNA. Translation: AEM17631.1.
RefSeqiNP_697303.1. NC_004310.3.
YP_005615123.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29218; AAN29218; BR0269.
AEM17631; AEM17631; BS1330_I0270.
KEGGibms:BR0269.
bsi:BS1330_I0270.
PATRICi17788827. VBIBruSui107850_0283.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29218.1.
CP002997 Genomic DNA. Translation: AEM17631.1.
RefSeqiNP_697303.1. NC_004310.3.
YP_005615123.1. NC_017251.1.

3D structure databases

ProteinModelPortaliQ8G2P9.
SMRiQ8G2P9. Positions 1-101.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204722.BR0269.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN29218; AAN29218; BR0269.
AEM17631; AEM17631; BS1330_I0270.
KEGGibms:BR0269.
bsi:BS1330_I0270.
PATRICi17788827. VBIBruSui107850_0283.

Phylogenomic databases

eggNOGiCOG0832.
HOGENOMiHOG000077770.
KOiK01429.
OMAiREVYGFQ.
OrthoDBiEOG69PQ9G.

Enzyme and pathway databases

UniPathwayiUPA00258; UER00370.

Family and domain databases

Gene3Di2.10.150.10. 1 hit.
HAMAPiMF_01954. Urease_beta.
InterProiIPR002019. Urease_beta.
[Graphical view]
PfamiPF00699. Urease_beta. 1 hit.
[Graphical view]
SUPFAMiSSF51278. SSF51278. 1 hit.
TIGRFAMsiTIGR00192. urease_beta. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. "Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice."
    Bandara A.B., Contreras A., Contreras-Rodriguez A., Martins A.M., Dobrean V., Poff-Reichow S., Rajasekaran P., Sriranganathan N., Schurig G.G., Boyle S.M.
    BMC Microbiol. 7:57-57(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION OF ROLE IN VIRULENCE, OPERON DISRUPTION.
    Strain: 1330.

Entry informationi

Entry nameiURE21_BRUSU
AccessioniPrimary (citable) accession number: Q8G2P9
Secondary accession number(s): G0KBW8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2006
Last sequence update: February 28, 2003
Last modified: March 31, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.