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Q8G2P9 (URE21_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Urease subunit beta 1

EC=3.5.1.5
Alternative name(s):
Urea amidohydrolase subunit beta 1
Gene names
Name:ureB1
Ordered Locus Names:BR0269, BS1330_I0270
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length101 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Disrupting the ure1 operon causes loss of urease activity, decreased resistance to low pH killing in vitro and decreased pathogen survival when innoculated in BALB/c mice by gavage. Ref.3

Catalytic activity

Urea + H2O = CO2 + 2 NH3. HAMAP-Rule MF_01954

Pathway

Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. HAMAP-Rule MF_01954

Subunit structure

Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01954.

Sequence similarities

Belongs to the urease beta subunit family.

Ontologies

Keywords
   Biological processVirulence
   Cellular componentCytoplasm
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpathogenesis

Inferred from electronic annotation. Source: UniProtKB-KW

urea catabolic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionurease activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 101101Urease subunit beta 1 HAMAP-Rule MF_01954
PRO_0000234238

Sequences

Sequence LengthMass (Da)Tools
Q8G2P9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: EC6F5DA786479D39

FASTA10111,337
        10         20         30         40         50         60 
MIPGEIITLE GDIELNQGQP TVTMRVANTG DRPIQVGSHF HFYEVNAALS FDREKARGQR 

        70         80         90        100 
LDIAAGTAVR FEPGQERDVT LVPIRGHREI YGFRQMIMGK L 

« Hide

References

« Hide 'large scale' references
[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[3]"Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice."
Bandara A.B., Contreras A., Contreras-Rodriguez A., Martins A.M., Dobrean V., Poff-Reichow S., Rajasekaran P., Sriranganathan N., Schurig G.G., Boyle S.M.
BMC Microbiol. 7:57-57(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION OF ROLE IN VIRULENCE, OPERON DISRUPTION.
Strain: 1330.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN29218.1.
CP002997 Genomic DNA. Translation: AEM17631.1.
RefSeqNP_697303.1. NC_004310.3.
YP_005615123.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G2P9.
SMRQ8G2P9. Positions 1-101.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR0269.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN29218; AAN29218; BR0269.
AEM17631; AEM17631; BS1330_I0270.
GeneID1165929.
12136588.
KEGGbms:BR0269.
bsi:BS1330_I0270.
PATRIC17788827. VBIBruSui107850_0283.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0832.
HOGENOMHOG000077770.
KOK01429.
OMAYGFRQLV.
OrthoDBEOG69PQ9G.

Enzyme and pathway databases

UniPathwayUPA00258; UER00370.

Family and domain databases

Gene3D2.10.150.10. 1 hit.
HAMAPMF_01954. Urease_beta.
InterProIPR002019. Urease_beta.
[Graphical view]
PfamPF00699. Urease_beta. 1 hit.
[Graphical view]
SUPFAMSSF51278. SSF51278. 1 hit.
TIGRFAMsTIGR00192. urease_beta. 1 hit.
ProtoNetSearch...

Entry information

Entry nameURE21_BRUSU
AccessionPrimary (citable) accession number: Q8G2P9
Secondary accession number(s): G0KBW8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names