Reviewed, UniProtKB/Swiss-Prot Q8G2K1 (MSCL_BRUSU)

Names and origin

Protein names

Recommended name:
    Large-conductance mechanosensitive channel

Gene names

Name:	mscL
Ordered Locus Names:	BR0318

Organism

Brucella suis [Complete proteome] [HAMAP]

Taxonomic identifier

29461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	138 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity.
Subunit structure	Homopentamer By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the mscL family.

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Ionic channel
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 138	138	Large-conductance mechanosensitive channel HAMAP MF_00115		PRO_0000192436
Regions
	Transmembrane	15 – 35	21	Potential
	Transmembrane	38 – 58	21	Potential
	Transmembrane	80 – 100	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8G2K1-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 64ADC7B8F6239A96	FASTA	138	14,899
	10 20 30 40 50 60 MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI DFSNMFIQLA 70 80 90 100 110 120 GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV KLMNRLKKRE EAKPAPAAPS 130 EEVLLTEIRD ILAKQQKA

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014291 Genomic DNA. Translation: AAN29267.1.
RefSeq	NP_697352.1.
3D structure databases
HSSP	HSSP built from PDB template 1MSL based on UniProtKB O53898.
ModBase	Search...
Genome annotation databases
GeneID	1165979.
GenomeReviews	Gene locus BR0318 in contig AE014291_GR.
KEGG	bms:BR0318.
TIGR	BR0318.
Phylogenomic databases
HOGENOM	Q8G2K1.
OMA	MIKEFKE.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_0318-MON.
Family and domain databases
HAMAP	MF_00115. [Tree]
InterPro	IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view]
Pfam	PF01741. MscL. 1 hit. [Graphical view]
PRINTS	PR01264. MECHCHANNEL.
ProDom	PD007253. MS_channel. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00220. mscL. 1 hit.
PROSITE	PS01327. MSCL. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MSCL_BRUSU

Accession

Primary (citable) accession number: Q8G2K1

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	March 1, 2003
Last modified:	November 3, 2009
This is version 33 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)