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Q8G2K1

- MSCL_BRUSU

UniProt

Q8G2K1 - MSCL_BRUSU

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Protein
Large-conductance mechanosensitive channel
Gene
mscL, BR0318, BS1330_I0319
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity.UniRule annotation

GO - Molecular functioni

  1. ion channel activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channel
Gene namesi
Name:mscL
Ordered Locus Names:BR0318, BS1330_I0319
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei15 – 3521Helical; Reviewed prediction
Add
BLAST
Transmembranei38 – 5821Helical; Reviewed prediction
Add
BLAST
Transmembranei80 – 10021Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 138138Large-conductance mechanosensitive channelUniRule annotation
PRO_0000192436Add
BLAST

Proteomic databases

PRIDEiQ8G2K1.

Interactioni

Subunit structurei

Homopentamer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR0318.

Structurei

3D structure databases

ProteinModelPortaliQ8G2K1.

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1970.
HOGENOMiHOG000226782.
KOiK03282.
OMAiFIQTVFD.
OrthoDBiEOG696C3G.

Family and domain databases

HAMAPiMF_00115. MscL.
InterProiIPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view]
PfamiPF01741. MscL. 1 hit.
[Graphical view]
PRINTSiPR01264. MECHCHANNEL.
SUPFAMiSSF81330. SSF81330. 1 hit.
TIGRFAMsiTIGR00220. mscL. 1 hit.
PROSITEiPS01327. MSCL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G2K1-1 [UniParc]FASTAAdd to Basket

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MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI    50
DFSNMFIQLA GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV 100
KLMNRLKKRE EAKPAPAAPS EEVLLTEIRD ILAKQQKA 138
Length:138
Mass (Da):14,899
Last modified:March 1, 2003 - v1
Checksum:i64ADC7B8F6239A96
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29267.1.
CP002997 Genomic DNA. Translation: AEM17680.1.
RefSeqiNP_697352.1. NC_004310.3.
YP_005615172.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29267; AAN29267; BR0318.
AEM17680; AEM17680; BS1330_I0319.
GeneIDi1165979.
12136638.
KEGGibms:BR0318.
bsi:BS1330_I0319.
PATRICi17788925. VBIBruSui107850_0331.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29267.1 .
CP002997 Genomic DNA. Translation: AEM17680.1 .
RefSeqi NP_697352.1. NC_004310.3.
YP_005615172.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G2K1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0318.

Proteomic databases

PRIDEi Q8G2K1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29267 ; AAN29267 ; BR0318 .
AEM17680 ; AEM17680 ; BS1330_I0319 .
GeneIDi 1165979.
12136638.
KEGGi bms:BR0318.
bsi:BS1330_I0319.
PATRICi 17788925. VBIBruSui107850_0331.

Phylogenomic databases

eggNOGi COG1970.
HOGENOMi HOG000226782.
KOi K03282.
OMAi FIQTVFD.
OrthoDBi EOG696C3G.

Family and domain databases

HAMAPi MF_00115. MscL.
InterProi IPR019823. Mechanosensitive_channel_CS.
IPR001185. MS_channel.
[Graphical view ]
Pfami PF01741. MscL. 1 hit.
[Graphical view ]
PRINTSi PR01264. MECHCHANNEL.
SUPFAMi SSF81330. SSF81330. 1 hit.
TIGRFAMsi TIGR00220. mscL. 1 hit.
PROSITEi PS01327. MSCL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiMSCL_BRUSU
AccessioniPrimary (citable) accession number: Q8G2K1
Secondary accession number(s): G0K674
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi