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Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Large-conductance mechanosensitive channelUniRule annotation
Gene namesi
Name:mscLUniRule annotation
Ordered Locus Names:BR0318, BS1330_I0319
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000007104 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei15 – 35HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21
Transmembranei80 – 100HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001924361 – 138Large-conductance mechanosensitive channelAdd BLAST138

Interactioni

Subunit structurei

Homopentamer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8G2K1
SMRiQ8G2K1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MscL family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000226782
KOiK03282
OMAiYGSFIQT

Family and domain databases

Gene3Di1.10.1200.120, 1 hit
HAMAPiMF_00115 MscL, 1 hit
InterProiView protein in InterPro
IPR036019 Gated_MS_channel
IPR019823 Mechanosensitive_channel_CS
IPR001185 MS_channel
IPR037673 MSC/AndL
PANTHERiPTHR30266 PTHR30266, 1 hit
PfamiView protein in Pfam
PF01741 MscL, 1 hit
PRINTSiPR01264 MECHCHANNEL
SUPFAMiSSF81330 SSF81330, 1 hit
TIGRFAMsiTIGR00220 mscL, 1 hit
PROSITEiView protein in PROSITE
PS01327 MSCL, 1 hit

Sequencei

Sequence statusi: Complete.

Q8G2K1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI
60 70 80 90 100
DFSNMFIQLA GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV
110 120 130
KLMNRLKKRE EAKPAPAAPS EEVLLTEIRD ILAKQQKA
Length:138
Mass (Da):14,899
Last modified:March 1, 2003 - v1
Checksum:i64ADC7B8F6239A96
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA Translation: AAN29267.1
CP002997 Genomic DNA Translation: AEM17680.1
RefSeqiWP_002963483.1, NZ_KN046804.1

Genome annotation databases

EnsemblBacteriaiAAN29267; AAN29267; BR0318
AEM17680; AEM17680; BS1330_I0319
GeneIDi29594451
KEGGibms:BR0318
bsi:BS1330_I0319
PATRICifig|204722.21.peg.2478

Similar proteinsi

Entry informationi

Entry nameiMSCL_BRUSU
AccessioniPrimary (citable) accession number: Q8G2K1
Secondary accession number(s): G0K674
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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