Reviewed,
UniProtKB/Swiss-Prot Q8G2K1 (MSCL_BRUSU)
Last modified
November 3, 2009.
Version 33.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Large-conductance mechanosensitive channel | ||||
| Gene names |
| ||||
| Organism | Brucella suis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 29461 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 138 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell By similarity. |
| Subunit structure | Homopentamer By similarity. |
| Subcellular location | Cell inner membrane; Multi-pass membrane protein By similarity. |
| Sequence similarities | Belongs to the mscL family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ion transport Transport |
| Cellular component | Cell inner membrane Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Ionic channel |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | ion transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: HAMAP |
| Molecular function | ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 138 | 138 | Large-conductance mechanosensitive channel HAMAP MF_00115 | PRO_0000192436 | |||||
Regions | |||||||||
| Transmembrane | 15 – 35 | 21 | Potential | ||||||
| Transmembrane | 38 – 58 | 21 | Potential | ||||||
| Transmembrane | 80 – 100 | 21 | Potential | ||||||
Sequences
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References
| [1] | "The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. Fraser C.M.Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1. |
Cross-references
Sequence databases | |
|---|---|
| AE014291 Genomic DNA. Translation: AAN29267.1. | |
| RefSeq | NP_697352.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1MSL based on UniProtKB O53898. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1165979. |
| GenomeReviews | Gene locus BR0318 in contig AE014291_GR. |
| KEGG | bms:BR0318. |
| TIGR | BR0318. |
Phylogenomic databases | |
| HOGENOM | Q8G2K1. |
| OMA | MIKEFKE. |
Enzyme and pathway databases | |
| BioCyc | BSUI204722:BR_0318-MON. |
Family and domain databases | |
| HAMAP | MF_00115. [Tree] |
| InterPro | IPR019823. Mechanosensitive_channel_CS. IPR001185. MS_channel. [Graphical view] |
| Pfam | PF01741. MscL. 1 hit. [Graphical view] |
| PRINTS | PR01264. MECHCHANNEL. |
| ProDom | PD007253. MS_channel. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| TIGRFAMs | TIGR00220. mscL. 1 hit. |
| PROSITE | PS01327. MSCL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MSCL_BRUSU | ||||||||
| Accession | Primary (citable) accession number: Q8G2K1 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella suis Brucella suis (strain 1330): entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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