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Q8G2K1

- MSCL_BRUSU

UniProt

Q8G2K1 - MSCL_BRUSU

Protein

Large-conductance mechanosensitive channel

Gene

mscL

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.UniRule annotation

    GO - Molecular functioni

    1. ion channel activity Source: InterPro

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Large-conductance mechanosensitive channelUniRule annotation
    Gene namesi
    Name:mscLUniRule annotation
    Ordered Locus Names:BR0318, BS1330_I0319
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Large-conductance mechanosensitive channelPRO_0000192436Add
    BLAST

    Proteomic databases

    PRIDEiQ8G2K1.

    Interactioni

    Subunit structurei

    Homopentamer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR0318.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G2K1.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei15 – 3521HelicalUniRule annotationAdd
    BLAST
    Transmembranei38 – 5821HelicalUniRule annotationAdd
    BLAST
    Transmembranei80 – 10021HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MscL family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1970.
    HOGENOMiHOG000226782.
    KOiK03282.
    OMAiFIQTVFD.
    OrthoDBiEOG696C3G.

    Family and domain databases

    HAMAPiMF_00115. MscL.
    InterProiIPR019823. Mechanosensitive_channel_CS.
    IPR001185. MS_channel.
    [Graphical view]
    PfamiPF01741. MscL. 1 hit.
    [Graphical view]
    PRINTSiPR01264. MECHCHANNEL.
    SUPFAMiSSF81330. SSF81330. 1 hit.
    TIGRFAMsiTIGR00220. mscL. 1 hit.
    PROSITEiPS01327. MSCL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G2K1-1 [UniParc]FASTAAdd to Basket

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    MLKEFQEFAL KGNMVDLAIG VIIGGAFGGL VNSIVNDIIM PIIGLITGGI    50
    DFSNMFIQLA GDPKTTLAAA REAGATIAYG NFITLLINFL IIAWVLFLVV 100
    KLMNRLKKRE EAKPAPAAPS EEVLLTEIRD ILAKQQKA 138
    Length:138
    Mass (Da):14,899
    Last modified:March 1, 2003 - v1
    Checksum:i64ADC7B8F6239A96
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29267.1.
    CP002997 Genomic DNA. Translation: AEM17680.1.
    RefSeqiNP_697352.1. NC_004310.3.
    YP_005615172.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29267; AAN29267; BR0318.
    AEM17680; AEM17680; BS1330_I0319.
    GeneIDi1165979.
    12136638.
    KEGGibms:BR0318.
    bsi:BS1330_I0319.
    PATRICi17788925. VBIBruSui107850_0331.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29267.1 .
    CP002997 Genomic DNA. Translation: AEM17680.1 .
    RefSeqi NP_697352.1. NC_004310.3.
    YP_005615172.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G2K1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0318.

    Proteomic databases

    PRIDEi Q8G2K1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29267 ; AAN29267 ; BR0318 .
    AEM17680 ; AEM17680 ; BS1330_I0319 .
    GeneIDi 1165979.
    12136638.
    KEGGi bms:BR0318.
    bsi:BS1330_I0319.
    PATRICi 17788925. VBIBruSui107850_0331.

    Phylogenomic databases

    eggNOGi COG1970.
    HOGENOMi HOG000226782.
    KOi K03282.
    OMAi FIQTVFD.
    OrthoDBi EOG696C3G.

    Family and domain databases

    HAMAPi MF_00115. MscL.
    InterProi IPR019823. Mechanosensitive_channel_CS.
    IPR001185. MS_channel.
    [Graphical view ]
    Pfami PF01741. MscL. 1 hit.
    [Graphical view ]
    PRINTSi PR01264. MECHCHANNEL.
    SUPFAMi SSF81330. SSF81330. 1 hit.
    TIGRFAMsi TIGR00220. mscL. 1 hit.
    PROSITEi PS01327. MSCL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiMSCL_BRUSU
    AccessioniPrimary (citable) accession number: Q8G2K1
    Secondary accession number(s): G0K674
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 30, 2005
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3