Reviewed, UniProtKB/Swiss-Prot Q8G2I1 (NORM_BRUSU)

Names and origin

Protein names

Recommended name:
    Probable multidrug resistance protein norM
Alternative name(s):
    Multidrug-efflux transporter

Gene names

Name:	norM
Ordered Locus Names:	BR0339

Organism

Brucella suis [Complete proteome] [HAMAP]

Taxonomic identifier

29461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	471 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Multidrug efflux pump By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. [View classification]

Ontologies

Keywords
Biological process	Antiport Ion transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ion transport Inferred from electronic annotation. Source: UniProtKB-KW multidrug transport Inferred from electronic annotation. Source: InterPro
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	antiporter activity Inferred from electronic annotation. Source: UniProtKB-KW drug transporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 471	471	Probable multidrug resistance protein norM		PRO_0000164209
Regions
	Transmembrane	30 – 52	23	Potential
	Transmembrane	67 – 89	23	Potential
	Transmembrane	110 – 132	23	Potential
	Transmembrane	147 – 169	23	Potential
	Transmembrane	176 – 198	23	Potential
	Transmembrane	208 – 230	23	Potential
	Transmembrane	255 – 277	23	Potential
	Transmembrane	287 – 309	23	Potential
	Transmembrane	330 – 352	23	Potential
	Transmembrane	372 – 389	18	Potential
	Transmembrane	410 – 432	23	Potential
	Transmembrane	436 – 458	23	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8G2I1-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: C2BFEC2A83B1ACA7	FASTA	471	51,685
	10 20 30 40 50 60 MDGTFDAGFR EPTISKANRW GREMVVALKL GWPLIFTNLS QAALTATDVI FIGRLGADTL 70 80 90 100 110 120 ASALLATSFY HTLMIFSMGL VSAVMPMIAI ALGKNRHSVR DVRRTVRQGF WSAIMIVIPL 130 140 150 160 170 180 WVVLWHCEEI FLFLGQRPDI AARSTDFMHT LQWALLPYLF YIVLRSFFAA MEKPMWTLLV 190 200 210 220 230 240 AALAIGFNAL AGWTLIFGHF GFAPMGLHGA GMATTASSTM MFLGLAFITL RHPRFRRYHL 250 260 270 280 290 300 FGRFWRPDWP RLIELWRIGL PMALTFVFET SIFYAAVVMM GRIGPTAMAA HAVAIQIASL 310 320 330 340 350 360 SFMVPLGFGQ VATVRVGRAY GRGDPKAIAY AGWSAYALGV GFMALMGILM VLMPRVFIGI 370 380 390 400 410 420 FLNLNDPQNL PVMELAVTFL ALAALFQIVD GAQAVAAGML RGLRDTRIPM LLALFGYWGV 430 440 450 460 470 GLPLGAVLAF QFGMGGVGIW LGLAAGLGMV AVLMTIRWRR HLAHVSAVAA A

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014291 Genomic DNA. Translation: AAN29288.1.
PIR	AC3450.
RefSeq	NP_697373.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1166000.
GenomeReviews	Gene locus BR0339 in contig AE014291_GR.
KEGG	bms:BR0339.
TIGR	BR0339.
Phylogenomic databases
HOGENOM	HBG479615.
OMA	AFWAGWR.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_0339-MON.
Family and domain databases
InterPro	IPR002528. MatE. [Graphical view]
PANTHER	PTHR11206. MatE. 1 hit.
Pfam	PF01554. MatE. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

NORM_BRUSU

Accession

Primary (citable) accession number: Q8G2I1

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 29, 2005
Last sequence update:	March 1, 2003
Last modified:	December 15, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)