Q8G2C7 (NHAA_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Na(+)/H(+) antiporter nhaA

Alternative name(s):
Sodium/proton antiporter nhaA

Gene names

Name:	nhaA
Ordered Locus Names:	BR0397, BS1330_I0398

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Na+/H+ antiporter that extrudes sodium in exchange for external protons By similarity. HAMAP MF_01844
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01844.
Sequence similarities	Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family. [View classification]

Ontologies

Keywords
Biological process	Antiport Ion transport Sodium transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Ligand	Sodium
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of pH Inferred from electronic annotation. Source: InterPro sodium ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	antiporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Na(+)/H(+) antiporter nhaA HAMAP MF_01844		PRO_0000334247
Regions
	Transmembrane	23 – 43	21	Helical; Potential
	Transmembrane	58 – 78	21	Helical; Potential
	Transmembrane	96 – 116	21	Helical; Potential
	Transmembrane	126 – 146	21	Helical; Potential
	Transmembrane	155 – 175	21	Helical; Potential
	Transmembrane	178 – 198	21	Helical; Potential
	Transmembrane	224 – 244	21	Helical; Potential
	Transmembrane	265 – 285	21	Helical; Potential
	Transmembrane	298 – 318	21	Helical; Potential
	Transmembrane	334 – 354	21	Helical; Potential
	Transmembrane	367 – 387	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8G2C7 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 1680414E86031FA2	FASTA	393	41,442
	10 20 30 40 50 60 MNHSPQSARP VSIMRRFLDS EAAGGITLMA AAALALIVAN SPFAQTYFDA LHLYIGPLSL 70 80 90 100 110 120 AHWINDALMA IFFLLVGLEI KREMLDGQLA SWPNRMLPGI AAAGGVILPA IIFAVLNHDN 130 140 150 160 170 180 PAKLRGWAVP SATDIAFALG VLSLLGSRAP SSLKVFLATL AILDDLAAVV IIAIFYTAEI 190 200 210 220 230 240 SMPYLGAAFI TAAVLFVMNR MGVVKLLPYL ISAVILWFFV FNSGVHATVA GVVAALMIPL 250 260 270 280 290 300 KPAPGRPDDM TSPLHKLEHA LAKPVAFIVV PIFGFANAGI SFKGLEASVL GDTLTLGILL 310 320 330 340 350 360 GLFLGKQFGV FGAAWLAIKT GLAEKPMGAS WVQLYGVAIL CGIGFTMSIF IGLLSFPSDL 370 380 390 MQTETKIGVL SGSALSAICG YLLLRAAARP KRG

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

[2]

"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed: 22038969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014291 Genomic DNA. Translation: AAN29343.1. CP002997 Genomic DNA. Translation: AEM17756.1.
RefSeq	NP_697428.1. NC_004310.3.
3D structure databases
HSSP	HSSP built from PDB template 1ZCD based on UniProtKB P13738.
ProteinModelPortal	Q8G2C7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1166058.
GenomeReviews	Gene locus BR0397 in contig AE014291_GR.
KEGG	bms:BR0397.
NMPDR	fig|204722.1.peg.385.
PATRIC	17789090. VBIBruSui107850_0413.
TIGR	BR0397.
Phylogenomic databases
HOGENOM	HBG665619.
OMA	LWFFMLQ.
PhylomeDB	Q8G2C7.
ProtClustDB	PRK09560.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_0397-MONOMER.
Family and domain databases
HAMAP	MF_01844. NhaA. [Tree]
InterPro	IPR023171. Na/H_antiporter_dom. IPR004670. NhaA. [Graphical view]
Gene3D	G3DSA:1.20.1530.10. G3DSA:1.20.1530.10. 1 hit.
KO	K03313.
Pfam	PF06965. Na_H_antiport_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00773. NhaA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NHAA_BRUSU

Accession

Primary (citable) accession number: Q8G2C7
Secondary accession number(s): G0K6L9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program