Reviewed, UniProtKB/Swiss-Prot Q8G2C7 (NHAA_BRUSU)

Names and origin

Protein names

Recommended name:
    Na(+)/H(+) antiporter nhaA
Alternative name(s):
    Sodium/proton antiporter nhaA

Gene names

Name:	nhaA
Ordered Locus Names:	BR0397

Organism

Brucella suis [Complete proteome] [HAMAP]

Taxonomic identifier

29461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	393 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Na+/H+ antiporter that extrudes sodium in exchange for external protons By similarity.
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family. [View classification]

Ontologies

Keywords
Biological process	Antiport Ion transport Sodium transport Transport
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Ligand	Sodium
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	regulation of pH Inferred from electronic annotation. Source: InterPro sodium ion transport Inferred from electronic annotation. Source: HAMAP
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	antiporter activity Inferred from electronic annotation. Source: HAMAP sodium ion binding Inferred from electronic annotation. Source: UniProtKB-KW sodium ion transmembrane transporter activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 393	393	Na(+)/H(+) antiporter nhaA HAMAP MF_01844		PRO_0000334247
Regions
	Transmembrane	23 – 43	21	Potential
	Transmembrane	58 – 78	21	Potential
	Transmembrane	96 – 116	21	Potential
	Transmembrane	126 – 146	21	Potential
	Transmembrane	155 – 175	21	Potential
	Transmembrane	178 – 198	21	Potential
	Transmembrane	224 – 244	21	Potential
	Transmembrane	265 – 285	21	Potential
	Transmembrane	298 – 318	21	Potential
	Transmembrane	334 – 354	21	Potential
	Transmembrane	367 – 387	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8G2C7-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 1680414E86031FA2	FASTA	393	41,442
	10 20 30 40 50 60 MNHSPQSARP VSIMRRFLDS EAAGGITLMA AAALALIVAN SPFAQTYFDA LHLYIGPLSL 70 80 90 100 110 120 AHWINDALMA IFFLLVGLEI KREMLDGQLA SWPNRMLPGI AAAGGVILPA IIFAVLNHDN 130 140 150 160 170 180 PAKLRGWAVP SATDIAFALG VLSLLGSRAP SSLKVFLATL AILDDLAAVV IIAIFYTAEI 190 200 210 220 230 240 SMPYLGAAFI TAAVLFVMNR MGVVKLLPYL ISAVILWFFV FNSGVHATVA GVVAALMIPL 250 260 270 280 290 300 KPAPGRPDDM TSPLHKLEHA LAKPVAFIVV PIFGFANAGI SFKGLEASVL GDTLTLGILL 310 320 330 340 350 360 GLFLGKQFGV FGAAWLAIKT GLAEKPMGAS WVQLYGVAIL CGIGFTMSIF IGLLSFPSDL 370 380 390 MQTETKIGVL SGSALSAICG YLLLRAAARP KRG

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014291 Genomic DNA. Translation: AAN29343.1.
RefSeq	NP_697428.1.
3D structure databases
HSSP	HSSP built from PDB template 1ZCD based on UniProtKB P13738.
ModBase	Search...
Genome annotation databases
GeneID	1166058.
GenomeReviews	Gene locus BR0397 in contig AE014291_GR.
KEGG	bms:BR0397.
NMPDR	fig|204722.1.peg.385.
TIGR	BR0397.
Phylogenomic databases
HOGENOM	Q8G2C7.
OMA	RPAGATW
Enzyme and pathway databases
BioCyc	BSUI204722:BR_0397-MON.
Family and domain databases
HAMAP	MF_01844. [Tree]
InterPro	IPR004670. NhaA. [Graphical view]
Pfam	PF06965. Na_H_antiport_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00773. NhaA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NHAA_BRUSU

Accession

Primary (citable) accession number: Q8G2C7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	March 1, 2003
Last modified:	November 24, 2009
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)