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Q8G292

- DXS_BRUSU

UniProt

Q8G292 - DXS_BRUSU

Protein

1-deoxy-D-xylulose-5-phosphate synthase

Gene

dxs

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).UniRule annotation

    Catalytic activityi

    Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei78 – 781Thiamine pyrophosphateUniRule annotation
    Metal bindingi150 – 1501MagnesiumUniRule annotation
    Metal bindingi179 – 1791MagnesiumUniRule annotation
    Binding sitei179 – 1791Thiamine pyrophosphateUniRule annotation
    Binding sitei288 – 2881Thiamine pyrophosphateUniRule annotation
    Binding sitei370 – 3701Thiamine pyrophosphateUniRule annotation

    GO - Molecular functioni

    1. 1-deoxy-D-xylulose-5-phosphate synthase activity Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. thiamine pyrophosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 1-deoxy-D-xylulose 5-phosphate biosynthetic process Source: UniProtKB-UniPathway
    2. terpenoid biosynthetic process Source: UniProtKB-HAMAP
    3. thiamine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Isoprene biosynthesis, Thiamine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    UniPathwayiUPA00064; UER00091.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-deoxy-D-xylulose-5-phosphate synthaseUniRule annotation (EC:2.2.1.7UniRule annotation)
    Alternative name(s):
    1-deoxyxylulose-5-phosphate synthaseUniRule annotation
    Short name:
    DXP synthaseUniRule annotation
    Short name:
    DXPSUniRule annotation
    Gene namesi
    Name:dxsUniRule annotation
    Ordered Locus Names:BS1330_I0437, BR0436
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 6436431-deoxy-D-xylulose-5-phosphate synthasePRO_0000189093Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR0436.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G292.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni119 – 1213Thiamine pyrophosphate bindingUniRule annotation
    Regioni151 – 1522Thiamine pyrophosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the transketolase family. DXPS subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1154.
    HOGENOMiHOG000012988.
    KOiK01662.
    OMAiMSTIRQK.
    OrthoDBiEOG6BKJ6P.

    Family and domain databases

    Gene3Di3.40.50.920. 1 hit.
    3.40.50.970. 3 hits.
    HAMAPiMF_00315. DXP_synth.
    InterProiIPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view]
    PfamiPF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view]
    SMARTiSM00861. Transket_pyr. 1 hit.
    [Graphical view]
    SUPFAMiSSF52518. SSF52518. 3 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsiTIGR00204. dxs. 1 hit.
    PROSITEiPS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G292-1 [UniParc]FASTAAdd to Basket

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    MSRPSTPLLD KAPTPDRLRA LPEQDLPQLA EELRTELIDA VSTTGGHLGA    50
    GLGVVELTVA LHHVFNTPYD RIIWDVGHQA YPHKILTGRR DRIRTLRQAG 100
    GLSGFTKRAE SEYDPFGAAH SSTSISAGLG MAVASELSGE KRNVIAVIGD 150
    GSMSAGMAYE AMNNAGALDA RLIVILNDND MSIAPPTGAM SAYLARLVSG 200
    RTYRSVREAA KQVAQKLPKF LQDKARKSEE YARAFFTGGT LFEELGFYYV 250
    GPIDGHNLDH LLPVLKNVRD TQKGPVLIHV VTQKGKGYAP AEAAADKYHG 300
    VNKFDVITGK QAKPPANVPS YTKIFGTSLI EEARHDDKIV AVTAAMPTGT 350
    GLDLFGEAFP KRVFDVGIAE QHAVTFAAGL ASEGYKPFCA IYSTFLQRGY 400
    DQVVHDVSIQ NLPVRFPIDR AGLVGADGPT HAGSFDTGFL AALPGFVVMA 450
    ASDEAELRHM VRTAAEYDEG PISFRYPRGD GVGVDLPERG SVLEIGKGRI 500
    VREGTKVALL SFGTRLQECL AAAEELGAAG LSTTVADARF AKPLDHDLIR 550
    RLAREHEVLV MVEEGAVGGF GSHVLQFLAT DGLLDRGLKV RALTLPDIYQ 600
    DHGKPDAMYA EAGLDRTGIV RTVFAALHRD ELGHEALPTP FRA 643
    Length:643
    Mass (Da):69,180
    Last modified:March 1, 2003 - v1
    Checksum:iE42DFB422D129FEA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29379.1.
    CP002997 Genomic DNA. Translation: AEM17792.1.
    RefSeqiNP_697464.1. NC_004310.3.
    YP_005615284.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29379; AAN29379; BR0436.
    AEM17792; AEM17792; BS1330_I0437.
    GeneIDi1166097.
    12136756.
    KEGGibms:BR0436.
    bsi:BS1330_I0437.
    PATRICi17789166. VBIBruSui107850_0451.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29379.1 .
    CP002997 Genomic DNA. Translation: AEM17792.1 .
    RefSeqi NP_697464.1. NC_004310.3.
    YP_005615284.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G292.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0436.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29379 ; AAN29379 ; BR0436 .
    AEM17792 ; AEM17792 ; BS1330_I0437 .
    GeneIDi 1166097.
    12136756.
    KEGGi bms:BR0436.
    bsi:BS1330_I0437.
    PATRICi 17789166. VBIBruSui107850_0451.

    Phylogenomic databases

    eggNOGi COG1154.
    HOGENOMi HOG000012988.
    KOi K01662.
    OMAi MSTIRQK.
    OrthoDBi EOG6BKJ6P.

    Enzyme and pathway databases

    UniPathwayi UPA00064 ; UER00091 .

    Miscellaneous databases

    PROi Q8G292.

    Family and domain databases

    Gene3Di 3.40.50.920. 1 hit.
    3.40.50.970. 3 hits.
    HAMAPi MF_00315. DXP_synth.
    InterProi IPR005477. Dxylulose-5-P_synthase.
    IPR029061. THDP-binding.
    IPR009014. Transketo_C/Pyr-ferredox_oxred.
    IPR005475. Transketolase-like_Pyr-bd.
    IPR020826. Transketolase_BS.
    IPR005476. Transketolase_C.
    IPR005474. Transketolase_N.
    [Graphical view ]
    Pfami PF13292. DXP_synthase_N. 1 hit.
    PF02779. Transket_pyr. 1 hit.
    PF02780. Transketolase_C. 1 hit.
    [Graphical view ]
    SMARTi SM00861. Transket_pyr. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52518. SSF52518. 3 hits.
    SSF52922. SSF52922. 1 hit.
    TIGRFAMsi TIGR00204. dxs. 1 hit.
    PROSITEi PS00801. TRANSKETOLASE_1. 1 hit.
    PS00802. TRANSKETOLASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiDXS_BRUSU
    AccessioniPrimary (citable) accession number: Q8G292
    Secondary accession number(s): G0K6Q5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3