Q8G285 (PSD_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylserine decarboxylase proenzyme
EC=4.1.1.65

Cleaved into the following 2 chains:

1. Phosphatidylserine decarboxylase alpha chain
2. Phosphatidylserine decarboxylase beta chain

Gene names

Name:	psd
Ordered Locus Names:	BR0443, BS1330_I0444

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	232 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Phosphatidyl-L-serine = phosphatidylethanolamine + CO2. HAMAP MF_00664
Cofactor	Pyruvoyl group By similarity. HAMAP MF_00664
Pathway	Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from CDP-diacylglycerol: step 2/2. HAMAP MF_00664
Sequence similarities	Belongs to the phosphatidylserine decarboxylase family. Type 3 subfamily.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Ligand	Pyruvate
Molecular function	Decarboxylase Lyase
PTM	Zymogen
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylethanolamine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	cofactor binding Inferred from electronic annotation. Source: InterPro phosphatidylserine decarboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	Phosphatidylserine decarboxylase beta chain By similarity		PRO_0000029761
	Chain	190 – 232	43	Phosphatidylserine decarboxylase alpha chain By similarity		PRO_0000029762
Sites
	Site	189 – 190	2	Cleavage (non-hydrolytic) By similarity
Amino acid modifications
	Modified residue	190	1	Pyruvic acid (Ser) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8G285 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 34915E274891E149	FASTA	232	25,794
	10 20 30 40 50 60 MSLTDTIRNT FVPIHREGYP FIAGFFVVSL ILGWLWDPLF WIGMVLTVWC IYFYRDPERV 70 80 90 100 110 120 TPMDDDLVIS PADGKVSFVG LAVPPAELDL GYEPMTRVSV FMNVFSVHIN RSPVRGKIDK 130 140 150 160 170 180 VVHRPGKFLN AELDKASTEN ERNSVLIESP HGKVGVVQIA GLVARRIVCW SNQDDELSVG 190 200 210 220 230 ERFGLIRFGS RVDVYLPSDA TVRVAVGQTA IAGETVLADY GTERGEPVVR IA

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

[2]

"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed: 22038969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014291 Genomic DNA. Translation: AAN29386.1. CP002997 Genomic DNA. Translation: AEM17799.1.
RefSeq	NP_697471.1. NC_004310.3.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1166104.
GenomeReviews	Gene locus BR0443 in contig AE014291_GR.
KEGG	bms:BR0443.
NMPDR	fig|204722.1.peg.428.
PATRIC	17789182. VBIBruSui107850_0459.
TIGR	BR0443.
Phylogenomic databases
HOGENOM	HBG541103.
OMA	IFMSVFN.
PhylomeDB	Q8G285.
ProtClustDB	PRK05305.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_0443-MONOMER.
Family and domain databases
HAMAP	MF_00664. PS_decarb_type3. [Tree]
InterPro	IPR003817. PS_Dcarbxylase. IPR004428. PtdSer_deCO2ase-related. [Graphical view]
KO	K01613.
Pfam	PF02666. PS_Dcarbxylase. 1 hit. [Graphical view]
TIGRFAMs	TIGR00164. PS_decarb_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PSD_BRUSU

Accession

Primary (citable) accession number: Q8G285
Secondary accession number(s): G0K6R2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 3, 2003
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 50 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program