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Q8G242

- MTB1_BRUSU

UniProt

Q8G242 - MTB1_BRUSU

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Protein

Modification methylase BabI

Gene
ccrM, babI, BR0491, BS1330_I0492
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability By similarity.

Catalytic activityi

S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

GO - Molecular functioni

  1. DNA binding Source: InterPro
  2. N-methyltransferase activity Source: InterPro
  3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

S-adenosyl-L-methionine

Protein family/group databases

REBASEi40994. M.Bsu1330ORF491P.

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase BabI (EC:2.1.1.72)
Short name:
M.BabI
Alternative name(s):
Adenine-specific methyltransferase BabI
DNA methyltransferase CcrM
M.CcrMI ortholog
Gene namesi
Name:ccrM
Synonyms:babI
Ordered Locus Names:BR0491, BS1330_I0492
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 377377Modification methylase BabIPRO_0000363189Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR0491.

Structurei

3D structure databases

ProteinModelPortaliQ8G242.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0863.
HOGENOMiHOG000125329.
KOiK13581.
OMAiFWHFEDG.
OrthoDBiEOG6FV84T.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view]
PfamiPF01555. N6_N4_Mtase. 1 hit.
[Graphical view]
PRINTSiPR00508. S21N4MTFRASE.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS00092. N6_MTASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G242-1 [UniParc]FASTAAdd to Basket

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MSLVRLAHEL PIEAPRTAWL DSIIKGDCVS ALERLPDHSV DVIFADPPYN    50
LQLGGDLHRP DQSMVSAVDD HWDQFESFQA YDAFTRAWLL ACRRVLKPNG 100
TIWVIGSYHN IFRVGTQLQD LGFWLLNDIV WRKTNPMPNF RGRRFQNAHE 150
TLIWASRDQK GKGYTFNYEA MKAANDDVQM RSDWLFPICT GSERLKDENG 200
DKVHPTQKPE ALLARIMMAS SKPGDVILDP FFGSGTTGAV AKRLGRHFVG 250
IEREQPYIDA ATARINAVEP LGKAELTVMT GKRAEPRVAF TSVMEAGLLR 300
PGTVLCDERR RFAAIVRADG TLTANGEAGS IHRIGARVQG FDACNGWTFW 350
HFEENGVLKP IDALRKIIRE QMAAAGA 377
Length:377
Mass (Da):42,188
Last modified:March 1, 2003 - v1
Checksum:i7E9D36B9F52BA83D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29434.1.
CP002997 Genomic DNA. Translation: AEM17847.1.
RefSeqiNP_697519.1. NC_004310.3.
YP_005615339.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29434; AAN29434; BR0491.
AEM17847; AEM17847; BS1330_I0492.
GeneIDi1166152.
12136811.
KEGGibms:BR0491.
bsi:BS1330_I0492.
PATRICi17789276. VBIBruSui107850_0506.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29434.1 .
CP002997 Genomic DNA. Translation: AEM17847.1 .
RefSeqi NP_697519.1. NC_004310.3.
YP_005615339.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G242.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0491.

Protein family/group databases

REBASEi 40994. M.Bsu1330ORF491P.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29434 ; AAN29434 ; BR0491 .
AEM17847 ; AEM17847 ; BS1330_I0492 .
GeneIDi 1166152.
12136811.
KEGGi bms:BR0491.
bsi:BS1330_I0492.
PATRICi 17789276. VBIBruSui107850_0506.

Phylogenomic databases

eggNOGi COG0863.
HOGENOMi HOG000125329.
KOi K13581.
OMAi FWHFEDG.
OrthoDBi EOG6FV84T.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
InterProi IPR002941. DNA_methylase_N4/N6.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR001091. RM_Methylase.
IPR029063. SAM-dependent_MTases-like.
[Graphical view ]
Pfami PF01555. N6_N4_Mtase. 1 hit.
[Graphical view ]
PRINTSi PR00508. S21N4MTFRASE.
SUPFAMi SSF53335. SSF53335. 1 hit.
PROSITEi PS00092. N6_MTASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiMTB1_BRUSU
AccessioniPrimary (citable) accession number: Q8G242
Secondary accession number(s): G0K740
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 10, 2009
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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