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Q8G242

- MTB1_BRUSU

UniProt

Q8G242 - MTB1_BRUSU

Protein

Modification methylase BabI

Gene

ccrM

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    This methylase recognizes the double-stranded sequence GANTC and causes specific methylation on A-2 on both strands. CcrM-mediated methylation has important cellular functions. Appears to contribute to the accurate cell-cycle control of DNA replication and cellular morphology. Essential for viability By similarity.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. N-methyltransferase activity Source: InterPro
    3. site-specific DNA-methyltransferase (adenine-specific) activity Source: UniProtKB-EC

    GO - Biological processi

    1. DNA replication Source: UniProtKB-KW

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Protein family/group databases

    REBASEi40994. M.Bsu1330ORF491P.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Modification methylase BabI (EC:2.1.1.72)
    Short name:
    M.BabI
    Alternative name(s):
    Adenine-specific methyltransferase BabI
    DNA methyltransferase CcrM
    M.CcrMI ortholog
    Gene namesi
    Name:ccrM
    Synonyms:babI
    Ordered Locus Names:BR0491, BS1330_I0492
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 377377Modification methylase BabIPRO_0000363189Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BR0491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G242.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the N(4)/N(6)-methyltransferase family.Curated

    Phylogenomic databases

    eggNOGiCOG0863.
    HOGENOMiHOG000125329.
    KOiK13581.
    OMAiFWHFEDG.
    OrthoDBiEOG6FV84T.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    InterProiIPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view]
    PfamiPF01555. N6_N4_Mtase. 1 hit.
    [Graphical view]
    PRINTSiPR00508. S21N4MTFRASE.
    SUPFAMiSSF53335. SSF53335. 1 hit.
    PROSITEiPS00092. N6_MTASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G242-1 [UniParc]FASTAAdd to Basket

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    MSLVRLAHEL PIEAPRTAWL DSIIKGDCVS ALERLPDHSV DVIFADPPYN    50
    LQLGGDLHRP DQSMVSAVDD HWDQFESFQA YDAFTRAWLL ACRRVLKPNG 100
    TIWVIGSYHN IFRVGTQLQD LGFWLLNDIV WRKTNPMPNF RGRRFQNAHE 150
    TLIWASRDQK GKGYTFNYEA MKAANDDVQM RSDWLFPICT GSERLKDENG 200
    DKVHPTQKPE ALLARIMMAS SKPGDVILDP FFGSGTTGAV AKRLGRHFVG 250
    IEREQPYIDA ATARINAVEP LGKAELTVMT GKRAEPRVAF TSVMEAGLLR 300
    PGTVLCDERR RFAAIVRADG TLTANGEAGS IHRIGARVQG FDACNGWTFW 350
    HFEENGVLKP IDALRKIIRE QMAAAGA 377
    Length:377
    Mass (Da):42,188
    Last modified:March 1, 2003 - v1
    Checksum:i7E9D36B9F52BA83D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29434.1.
    CP002997 Genomic DNA. Translation: AEM17847.1.
    RefSeqiNP_697519.1. NC_004310.3.
    YP_005615339.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29434; AAN29434; BR0491.
    AEM17847; AEM17847; BS1330_I0492.
    GeneIDi1166152.
    12136811.
    KEGGibms:BR0491.
    bsi:BS1330_I0492.
    PATRICi17789276. VBIBruSui107850_0506.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29434.1 .
    CP002997 Genomic DNA. Translation: AEM17847.1 .
    RefSeqi NP_697519.1. NC_004310.3.
    YP_005615339.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G242.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0491.

    Protein family/group databases

    REBASEi 40994. M.Bsu1330ORF491P.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29434 ; AAN29434 ; BR0491 .
    AEM17847 ; AEM17847 ; BS1330_I0492 .
    GeneIDi 1166152.
    12136811.
    KEGGi bms:BR0491.
    bsi:BS1330_I0492.
    PATRICi 17789276. VBIBruSui107850_0506.

    Phylogenomic databases

    eggNOGi COG0863.
    HOGENOMi HOG000125329.
    KOi K13581.
    OMAi FWHFEDG.
    OrthoDBi EOG6FV84T.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    InterProi IPR002941. DNA_methylase_N4/N6.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR001091. RM_Methylase.
    IPR029063. SAM-dependent_MTases-like.
    [Graphical view ]
    Pfami PF01555. N6_N4_Mtase. 1 hit.
    [Graphical view ]
    PRINTSi PR00508. S21N4MTFRASE.
    SUPFAMi SSF53335. SSF53335. 1 hit.
    PROSITEi PS00092. N6_MTASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiMTB1_BRUSU
    AccessioniPrimary (citable) accession number: Q8G242
    Secondary accession number(s): G0K740
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 10, 2009
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3