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Protein

HTH-type transcriptional regulator BetI

Gene

betI

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine (By similarity).By similarity

Pathway:ibetaine biosynthesis via choline pathway

This protein regulates the pathway betaine biosynthesis via choline pathway, which is part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi31 – 5020H-T-H motifUniRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

UniPathwayiUPA00529.

Names & Taxonomyi

Protein namesi
Recommended name:
HTH-type transcriptional regulator BetIUniRule annotation
Gene namesi
Name:betIUniRule annotation
Ordered Locus Names:BR0554, BS1330_I0550
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198HTH-type transcriptional regulator BetIPRO_0000070579Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ8G1Z7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini8 – 6861HTH tetR-typeUniRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000248227.
KOiK02167.
OMAiFLVIYAR.
OrthoDBiEOG6FFS5N.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_00768. HTH_type_BetI.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR017757. Tscrpt_rep_BetI.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
TIGRFAMsiTIGR03384. betaine_BetI. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G1Z7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKIGMEPLR RRELIDAAIR TIGQRGSLDV TVAQIAHEAG VSPALAHHYF
60 70 80 90 100
GGKDKLILAT MRHLLRELGR DLNAAIKQAN APHERIAAII AVNFSAAQFA
110 120 130 140 150
QETIAAWLTF YVHAQQSDDI KRLLRIYARR LHSNLVFALE QLTSRARANR
160 170 180 190
IAEGAGAMID GLYIRHALGA DAPDAASAIA LVEDYIAIQL SGQPSAEN
Length:198
Mass (Da):21,590
Last modified:March 1, 2003 - v1
Checksum:iBC8AF3275FC875EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29485.1.
CP002997 Genomic DNA. Translation: AEM17902.1.
RefSeqiWP_006189969.1. NZ_KN046804.1.

Genome annotation databases

EnsemblBacteriaiAAN29485; AAN29485; BR0554.
AEM17902; AEM17902; BS1330_I0550.
KEGGibms:BR0554.
bsi:BS1330_I0550.
PATRICi17789407. VBIBruSui107850_0571.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29485.1.
CP002997 Genomic DNA. Translation: AEM17902.1.
RefSeqiWP_006189969.1. NZ_KN046804.1.

3D structure databases

ProteinModelPortaliQ8G1Z7.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN29485; AAN29485; BR0554.
AEM17902; AEM17902; BS1330_I0550.
KEGGibms:BR0554.
bsi:BS1330_I0550.
PATRICi17789407. VBIBruSui107850_0571.

Phylogenomic databases

eggNOGiCOG1309.
HOGENOMiHOG000248227.
KOiK02167.
OMAiFLVIYAR.
OrthoDBiEOG6FFS5N.

Enzyme and pathway databases

UniPathwayiUPA00529.

Family and domain databases

Gene3Di1.10.357.10. 1 hit.
HAMAPiMF_00768. HTH_type_BetI.
InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
IPR009057. Homeodomain-like.
IPR001647. HTH_TetR.
IPR015893. Tet_transcr_reg_TetR-like_C.
IPR011075. Tet_transcr_reg_TetR-rel_C.
IPR017757. Tscrpt_rep_BetI.
[Graphical view]
PfamiPF00440. TetR_N. 1 hit.
[Graphical view]
PRINTSiPR00455. HTHTETR.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF48498. SSF48498. 1 hit.
TIGRFAMsiTIGR03384. betaine_BetI. 1 hit.
PROSITEiPS01081. HTH_TETR_1. 1 hit.
PS50977. HTH_TETR_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiBETI_BRUSU
AccessioniPrimary (citable) accession number: Q8G1Z7
Secondary accession number(s): G0K7H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.