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Q8G1Z7

- BETI_BRUSU

UniProt

Q8G1Z7 - BETI_BRUSU

Protein

HTH-type transcriptional regulator BetI

Gene

betI

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Repressor involved in the biosynthesis of the osmoprotectant glycine betaine. It represses transcription of the choline transporter BetT and the genes of BetAB involved in the synthesis of glycine betaine By similarity.By similarity

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi31 – 5020H-T-H motifUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. sequence-specific DNA binding transcription factor activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
    2. negative regulation of transcription, DNA-templated Source: UniProtKB-HAMAP
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    UniPathwayiUPA00529.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    HTH-type transcriptional regulator BetIUniRule annotation
    Gene namesi
    Name:betIUniRule annotation
    Ordered Locus Names:BR0554, BS1330_I0550
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198HTH-type transcriptional regulator BetIPRO_0000070579Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BR0554.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G1Z7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 6861HTH tetR-typeUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH tetR-type DNA-binding domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1309.
    HOGENOMiHOG000248227.
    KOiK02167.
    OMAiGIINHYF.
    OrthoDBiEOG6FFS5N.

    Family and domain databases

    Gene3Di1.10.357.10. 1 hit.
    HAMAPiMF_00768. HTH_type_BetI.
    InterProiIPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    IPR017757. Tscrpt_rep_BetI.
    [Graphical view]
    PfamiPF00440. TetR_N. 1 hit.
    [Graphical view]
    PRINTSiPR00455. HTHTETR.
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    TIGRFAMsiTIGR03384. betaine_BetI. 1 hit.
    PROSITEiPS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G1Z7-1 [UniParc]FASTAAdd to Basket

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    MPKIGMEPLR RRELIDAAIR TIGQRGSLDV TVAQIAHEAG VSPALAHHYF    50
    GGKDKLILAT MRHLLRELGR DLNAAIKQAN APHERIAAII AVNFSAAQFA 100
    QETIAAWLTF YVHAQQSDDI KRLLRIYARR LHSNLVFALE QLTSRARANR 150
    IAEGAGAMID GLYIRHALGA DAPDAASAIA LVEDYIAIQL SGQPSAEN 198
    Length:198
    Mass (Da):21,590
    Last modified:March 1, 2003 - v1
    Checksum:iBC8AF3275FC875EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29485.1.
    CP002997 Genomic DNA. Translation: AEM17902.1.
    RefSeqiNP_697570.1. NC_004310.3.
    YP_005615394.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29485; AAN29485; BR0554.
    AEM17902; AEM17902; BS1330_I0550.
    GeneIDi1166216.
    12136870.
    KEGGibms:BR0554.
    bsi:BS1330_I0550.
    PATRICi17789407. VBIBruSui107850_0571.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29485.1 .
    CP002997 Genomic DNA. Translation: AEM17902.1 .
    RefSeqi NP_697570.1. NC_004310.3.
    YP_005615394.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G1Z7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0554.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29485 ; AAN29485 ; BR0554 .
    AEM17902 ; AEM17902 ; BS1330_I0550 .
    GeneIDi 1166216.
    12136870.
    KEGGi bms:BR0554.
    bsi:BS1330_I0550.
    PATRICi 17789407. VBIBruSui107850_0571.

    Phylogenomic databases

    eggNOGi COG1309.
    HOGENOMi HOG000248227.
    KOi K02167.
    OMAi GIINHYF.
    OrthoDBi EOG6FFS5N.

    Enzyme and pathway databases

    UniPathwayi UPA00529 .

    Family and domain databases

    Gene3Di 1.10.357.10. 1 hit.
    HAMAPi MF_00768. HTH_type_BetI.
    InterProi IPR023772. DNA-bd_HTH_TetR-type_CS.
    IPR009057. Homeodomain-like.
    IPR001647. HTH_TetR.
    IPR015893. Tet_transcr_reg_TetR-like_C.
    IPR011075. Tet_transcr_reg_TetR-rel_C.
    IPR017757. Tscrpt_rep_BetI.
    [Graphical view ]
    Pfami PF00440. TetR_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00455. HTHTETR.
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF48498. SSF48498. 1 hit.
    TIGRFAMsi TIGR03384. betaine_BetI. 1 hit.
    PROSITEi PS01081. HTH_TETR_1. 1 hit.
    PS50977. HTH_TETR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiBETI_BRUSU
    AccessioniPrimary (citable) accession number: Q8G1Z7
    Secondary accession number(s): G0K7H4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 71 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3