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Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Heme (covalent; via pros nitrogen)UniRule annotation
Metal bindingi147 – 1471Iron (heme axial ligand)UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmEUniRule annotation
Alternative name(s):
Cytochrome c maturation protein EUniRule annotation
Heme chaperone CcmEUniRule annotation
Gene namesi
Name:ccmEUniRule annotation
Synonyms:cycJUniRule annotation
Ordered Locus Names:BR0608, BS1330_I0604
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I UP000000824 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929CytoplasmicUniRule annotationAdd
BLAST
Transmembranei30 – 5021Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd
BLAST
Topological domaini51 – 165115PeriplasmicUniRule annotationAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Cytochrome c-type biogenesis protein CcmEPRO_0000238801Add
BLAST

Proteomic databases

PRIDEiQ8G1U5.

Interactioni

Protein-protein interaction databases

STRINGi204722.BR0608.

Structurei

3D structure databases

ProteinModelPortaliQ8G1U5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.UniRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2332.
HOGENOMiHOG000009661.
KOiK02197.
OMAiLVMYALR.
OrthoDBiEOG69D3JN.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01959. CcmE.
InterProiIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G1U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATAEQNAR NPKGKGGFAR TVSQRKRKRL FLIGGALAVL AVAVGLMLTA
60 70 80 90 100
FNQDIRFFRT PADLTEQDMT SGARFRLGGL VEEGSVSRTG SELRFTVTDT
110 120 130 140 150
IKTVKVVFEG IPPDLFREGQ GVVAEGRFGS DGLFRADNVL AKHDENYVPK
160
DLADSLKKKG VWEGK
Length:165
Mass (Da):17,977
Last modified:March 1, 2003 - v1
Checksum:iF67EB3C3641DCC6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29537.1.
CP002997 Genomic DNA. Translation: AEM17954.1.
PIRiAG3418.
RefSeqiNP_697622.1. NC_004310.3.
WP_002963757.1. NZ_KN046804.1.
YP_005615446.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29537; AAN29537; BR0608.
AEM17954; AEM17954; BS1330_I0604.
GeneIDi3788646.
KEGGibms:BR0608.
bsi:BS1330_I0604.
PATRICi17789515. VBIBruSui107850_0625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29537.1.
CP002997 Genomic DNA. Translation: AEM17954.1.
PIRiAG3418.
RefSeqiNP_697622.1. NC_004310.3.
WP_002963757.1. NZ_KN046804.1.
YP_005615446.1. NC_017251.1.

3D structure databases

ProteinModelPortaliQ8G1U5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204722.BR0608.

Proteomic databases

PRIDEiQ8G1U5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN29537; AAN29537; BR0608.
AEM17954; AEM17954; BS1330_I0604.
GeneIDi3788646.
KEGGibms:BR0608.
bsi:BS1330_I0604.
PATRICi17789515. VBIBruSui107850_0625.

Phylogenomic databases

eggNOGiCOG2332.
HOGENOMiHOG000009661.
KOiK02197.
OMAiLVMYALR.
OrthoDBiEOG69D3JN.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01959. CcmE.
InterProiIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiCCME_BRUSU
AccessioniPrimary (citable) accession number: Q8G1U5
Secondary accession number(s): G0K7M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: May 27, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.