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Q8G1U5

- CCME_BRUSU

UniProt

Q8G1U5 - CCME_BRUSU

Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei143 – 1431Heme (covalent; via pros nitrogen)UniRule annotation
    Metal bindingi147 – 1471Iron (heme axial ligand)UniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cytochrome complex assembly Source: UniProtKB-KW
    2. protein-heme linkage Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Cytochrome c-type biogenesis

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c-type biogenesis protein CcmEUniRule annotation
    Alternative name(s):
    Cytochrome c maturation protein EUniRule annotation
    Heme chaperone CcmEUniRule annotation
    Gene namesi
    Name:ccmEUniRule annotation
    Synonyms:cycJUniRule annotation
    Ordered Locus Names:BR0608, BS1330_I0604
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 165165Cytochrome c-type biogenesis protein CcmEPRO_0000238801Add
    BLAST

    Proteomic databases

    PRIDEiQ8G1U5.

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BR0608.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G1U5.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929CytoplasmicUniRule annotationAdd
    BLAST
    Topological domaini51 – 165115PeriplasmicUniRule annotationAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the CcmE/CycJ family.UniRule annotation

    Keywords - Domaini

    Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2332.
    HOGENOMiHOG000009661.
    KOiK02197.
    OMAiLVMYALR.
    OrthoDBiEOG69D3JN.

    Family and domain databases

    Gene3Di2.40.50.140. 1 hit.
    HAMAPiMF_01959. CcmE.
    InterProiIPR004329. CcmE.
    IPR012340. NA-bd_OB-fold.
    [Graphical view]
    PfamiPF03100. CcmE. 1 hit.
    [Graphical view]
    SUPFAMiSSF82093. SSF82093. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8G1U5-1 [UniParc]FASTAAdd to Basket

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    MSATAEQNAR NPKGKGGFAR TVSQRKRKRL FLIGGALAVL AVAVGLMLTA    50
    FNQDIRFFRT PADLTEQDMT SGARFRLGGL VEEGSVSRTG SELRFTVTDT 100
    IKTVKVVFEG IPPDLFREGQ GVVAEGRFGS DGLFRADNVL AKHDENYVPK 150
    DLADSLKKKG VWEGK 165
    Length:165
    Mass (Da):17,977
    Last modified:March 1, 2003 - v1
    Checksum:iF67EB3C3641DCC6F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29537.1.
    CP002997 Genomic DNA. Translation: AEM17954.1.
    PIRiAG3418.
    RefSeqiNP_697622.1. NC_004310.3.
    YP_005615446.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29537; AAN29537; BR0608.
    AEM17954; AEM17954; BS1330_I0604.
    GeneIDi1166270.
    12136924.
    KEGGibms:BR0608.
    bsi:BS1330_I0604.
    PATRICi17789515. VBIBruSui107850_0625.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29537.1 .
    CP002997 Genomic DNA. Translation: AEM17954.1 .
    PIRi AG3418.
    RefSeqi NP_697622.1. NC_004310.3.
    YP_005615446.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G1U5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0608.

    Proteomic databases

    PRIDEi Q8G1U5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29537 ; AAN29537 ; BR0608 .
    AEM17954 ; AEM17954 ; BS1330_I0604 .
    GeneIDi 1166270.
    12136924.
    KEGGi bms:BR0608.
    bsi:BS1330_I0604.
    PATRICi 17789515. VBIBruSui107850_0625.

    Phylogenomic databases

    eggNOGi COG2332.
    HOGENOMi HOG000009661.
    KOi K02197.
    OMAi LVMYALR.
    OrthoDBi EOG69D3JN.

    Family and domain databases

    Gene3Di 2.40.50.140. 1 hit.
    HAMAPi MF_01959. CcmE.
    InterProi IPR004329. CcmE.
    IPR012340. NA-bd_OB-fold.
    [Graphical view ]
    Pfami PF03100. CcmE. 1 hit.
    [Graphical view ]
    SUPFAMi SSF82093. SSF82093. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiCCME_BRUSU
    AccessioniPrimary (citable) accession number: Q8G1U5
    Secondary accession number(s): G0K7M6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3