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Q8G1U5 (CCME_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cytochrome c-type biogenesis protein CcmE
Alternative name(s):
Cytochrome c maturation protein E
Heme chaperone CcmE
Gene names
Name:ccmE
Synonyms:cycJ
Ordered Locus Names:BR0608, BS1330_I0604
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length165 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH By similarity. HAMAP-Rule MF_01959

Subcellular location

Cell inner membrane; Single-pass type II membrane protein; Periplasmic side Potential HAMAP-Rule MF_01959.

Sequence similarities

Belongs to the CcmE/CycJ family.

Ontologies

Keywords
   Biological processCytochrome c-type biogenesis
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainSignal-anchor
Transmembrane
Transmembrane helix
   LigandHeme
Iron
Metal-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processcytochrome complex assembly

Inferred from electronic annotation. Source: UniProtKB-KW

protein-heme linkage

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionmetal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 165165Cytochrome c-type biogenesis protein CcmE HAMAP-Rule MF_01959
PRO_0000238801

Regions

Topological domain1 – 2929Cytoplasmic Potential
Transmembrane30 – 5021Helical; Signal-anchor for type II membrane protein; Potential
Topological domain51 – 165115Periplasmic Potential

Sites

Metal binding1471Iron (heme axial ligand) By similarity
Binding site1431Heme (covalent; via pros nitrogen) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G1U5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F67EB3C3641DCC6F

FASTA16517,977
        10         20         30         40         50         60 
MSATAEQNAR NPKGKGGFAR TVSQRKRKRL FLIGGALAVL AVAVGLMLTA FNQDIRFFRT 

        70         80         90        100        110        120 
PADLTEQDMT SGARFRLGGL VEEGSVSRTG SELRFTVTDT IKTVKVVFEG IPPDLFREGQ 

       130        140        150        160 
GVVAEGRFGS DGLFRADNVL AKHDENYVPK DLADSLKKKG VWEGK 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN29537.1.
CP002997 Genomic DNA. Translation: AEM17954.1.
PIRAG3418.
RefSeqNP_697622.1. NC_004310.3.
YP_005615446.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G1U5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR0608.

Proteomic databases

PRIDEQ8G1U5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN29537; AAN29537; BR0608.
AEM17954; AEM17954; BS1330_I0604.
GeneID1166270.
12136924.
KEGGbms:BR0608.
bsi:BS1330_I0604.
PATRIC17789515. VBIBruSui107850_0625.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2332.
HOGENOMHOG000009661.
KOK02197.
OMALVMYALR.
OrthoDBEOG69D3JN.

Family and domain databases

Gene3D2.40.50.140. 1 hit.
HAMAPMF_01959. CcmE.
InterProIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMSSF82093. SSF82093. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCCME_BRUSU
AccessionPrimary (citable) accession number: Q8G1U5
Secondary accession number(s): G0K7M6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names