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Q8G1U5

- CCME_BRUSU

UniProt

Q8G1U5 - CCME_BRUSU

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Protein
Cytochrome c-type biogenesis protein CcmE
Gene
ccmE, cycJ, BR0608, BS1330_I0604
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei143 – 1431Heme (covalent; via pros nitrogen) By similarity
Metal bindingi147 – 1471Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. cytochrome complex assembly Source: UniProtKB-KW
  2. protein-heme linkage Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cytochrome c-type biogenesis

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmE
Alternative name(s):
Cytochrome c maturation protein E
Heme chaperone CcmE
Gene namesi
Name:ccmE
Synonyms:cycJ
Ordered Locus Names:BR0608, BS1330_I0604
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei30 – 5021Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini51 – 165115Periplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 165165Cytochrome c-type biogenesis protein CcmEUniRule annotation
PRO_0000238801Add
BLAST

Proteomic databases

PRIDEiQ8G1U5.

Interactioni

Protein-protein interaction databases

STRINGi204722.BR0608.

Structurei

3D structure databases

ProteinModelPortaliQ8G1U5.

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2332.
HOGENOMiHOG000009661.
KOiK02197.
OMAiLVMYALR.
OrthoDBiEOG69D3JN.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01959. CcmE.
InterProiIPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF03100. CcmE. 1 hit.
[Graphical view]
SUPFAMiSSF82093. SSF82093. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G1U5-1 [UniParc]FASTAAdd to Basket

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MSATAEQNAR NPKGKGGFAR TVSQRKRKRL FLIGGALAVL AVAVGLMLTA    50
FNQDIRFFRT PADLTEQDMT SGARFRLGGL VEEGSVSRTG SELRFTVTDT 100
IKTVKVVFEG IPPDLFREGQ GVVAEGRFGS DGLFRADNVL AKHDENYVPK 150
DLADSLKKKG VWEGK 165
Length:165
Mass (Da):17,977
Last modified:March 1, 2003 - v1
Checksum:iF67EB3C3641DCC6F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29537.1.
CP002997 Genomic DNA. Translation: AEM17954.1.
PIRiAG3418.
RefSeqiNP_697622.1. NC_004310.3.
YP_005615446.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29537; AAN29537; BR0608.
AEM17954; AEM17954; BS1330_I0604.
GeneIDi1166270.
12136924.
KEGGibms:BR0608.
bsi:BS1330_I0604.
PATRICi17789515. VBIBruSui107850_0625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29537.1 .
CP002997 Genomic DNA. Translation: AEM17954.1 .
PIRi AG3418.
RefSeqi NP_697622.1. NC_004310.3.
YP_005615446.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G1U5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 204722.BR0608.

Proteomic databases

PRIDEi Q8G1U5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29537 ; AAN29537 ; BR0608 .
AEM17954 ; AEM17954 ; BS1330_I0604 .
GeneIDi 1166270.
12136924.
KEGGi bms:BR0608.
bsi:BS1330_I0604.
PATRICi 17789515. VBIBruSui107850_0625.

Phylogenomic databases

eggNOGi COG2332.
HOGENOMi HOG000009661.
KOi K02197.
OMAi LVMYALR.
OrthoDBi EOG69D3JN.

Family and domain databases

Gene3Di 2.40.50.140. 1 hit.
HAMAPi MF_01959. CcmE.
InterProi IPR004329. CcmE.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF03100. CcmE. 1 hit.
[Graphical view ]
SUPFAMi SSF82093. SSF82093. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiCCME_BRUSU
AccessioniPrimary (citable) accession number: Q8G1U5
Secondary accession number(s): G0K7M6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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