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Protein

Cytochrome c-type biogenesis protein CcmE

Gene

ccmE

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143Heme (covalent; via pros nitrogen)UniRule annotation1
Metal bindingi147Iron (heme axial ligand)UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCytochrome c-type biogenesis
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-type biogenesis protein CcmEUniRule annotation
Alternative name(s):
Cytochrome c maturation protein EUniRule annotation
Heme chaperone CcmEUniRule annotation
Gene namesi
Name:ccmEUniRule annotation
Synonyms:cycJUniRule annotation
Ordered Locus Names:BR0608, BS1330_I0604
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000007104 Componenti: Chromosome I

Subcellular locationi

  • Cell inner membrane UniRule annotation; Single-pass type II membrane protein UniRule annotation; Periplasmic side UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29CytoplasmicUniRule annotationAdd BLAST29
Transmembranei30 – 50Helical; Signal-anchor for type II membrane proteinUniRule annotationAdd BLAST21
Topological domaini51 – 165PeriplasmicUniRule annotationAdd BLAST115

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002388011 – 165Cytochrome c-type biogenesis protein CcmEAdd BLAST165

Structurei

3D structure databases

ProteinModelPortaliQ8G1U5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CcmE/CycJ family.UniRule annotation

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000009661
KOiK02197
OMAiHVEFAVH

Family and domain databases

HAMAPiMF_01959 CcmE, 1 hit
InterProiView protein in InterPro
IPR004329 CcmE
IPR036127 CcmE-like_sf
PANTHERiPTHR34128 PTHR34128, 1 hit
PfamiView protein in Pfam
PF03100 CcmE, 1 hit
SUPFAMiSSF82093 SSF82093, 1 hit

Sequencei

Sequence statusi: Complete.

Q8G1U5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSATAEQNAR NPKGKGGFAR TVSQRKRKRL FLIGGALAVL AVAVGLMLTA
60 70 80 90 100
FNQDIRFFRT PADLTEQDMT SGARFRLGGL VEEGSVSRTG SELRFTVTDT
110 120 130 140 150
IKTVKVVFEG IPPDLFREGQ GVVAEGRFGS DGLFRADNVL AKHDENYVPK
160
DLADSLKKKG VWEGK
Length:165
Mass (Da):17,977
Last modified:March 1, 2003 - v1
Checksum:iF67EB3C3641DCC6F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA Translation: AAN29537.1
CP002997 Genomic DNA Translation: AEM17954.1
PIRiAG3418
RefSeqiWP_002963757.1, NZ_KN046804.1

Genome annotation databases

EnsemblBacteriaiAAN29537; AAN29537; BR0608
AEM17954; AEM17954; BS1330_I0604
GeneIDi29594183
KEGGibms:BR0608
bsi:BS1330_I0604
PATRICifig|204722.21.peg.2050

Similar proteinsi

Entry informationi

Entry nameiCCME_BRUSU
AccessioniPrimary (citable) accession number: Q8G1U5
Secondary accession number(s): G0K7M6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: April 25, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome
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Main funding by: National Institutes of Health