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Q8G1K5

- PUR5_BRUSU

UniProt

Q8G1K5 - PUR5_BRUSU

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, BR0710, BS1330_I0706
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:BR0710, BS1330_I0706
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 359359Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_0000148203Add
BLAST

Proteomic databases

PRIDEiQ8G1K5.

Interactioni

Protein-protein interaction databases

STRINGi204722.BR0710.

Structurei

3D structure databases

ProteinModelPortaliQ8G1K5.
SMRiQ8G1K5. Positions 12-355.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G1K5-1 [UniParc]FASTAAdd to Basket

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MTMENKPAGQ NGLTYAQAGV DIDAGNLMVE KIKPLVRSTR RPGADGEIGG    50
FGGLFDLKAA GFKDPVLVAA NDGVGTKLKI AIDADIHDTV GIDLVAMCVN 100
DLVVQGAEPL FFLDYYATGK LSPDQGVAIV SGIAEGCRQA GCALIGGETA 150
EMPGMYRDGD YDLAGFAVGA AERDRLLPRG DIAEGDIILG LASSGVHSNG 200
FSLVRRIVEL SGLGWKSQAP FQPGATLGEA LLTPTRIYVK PLLAAIRACD 250
GIKALAHITG GGFPDNIPRV LPKGLAAEID LPAIAVPPVF SWLAKTGNVE 300
PNEMLRTFNC GIGMIAVVNP AKVDEVIAAL AAEGEKVVTL GRMTRREKDG 350
VIYKGQLAL 359
Length:359
Mass (Da):37,447
Last modified:March 1, 2003 - v1
Checksum:i594BAB33E3F569F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29639.1.
CP002997 Genomic DNA. Translation: AEM18056.1.
RefSeqiNP_697724.1. NC_004310.3.
YP_005615548.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29639; AAN29639; BR0710.
AEM18056; AEM18056; BS1330_I0706.
GeneIDi1166373.
12137027.
KEGGibms:BR0710.
bsi:BS1330_I0706.
PATRICi17789713. VBIBruSui107850_0723.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29639.1 .
CP002997 Genomic DNA. Translation: AEM18056.1 .
RefSeqi NP_697724.1. NC_004310.3.
YP_005615548.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G1K5.
SMRi Q8G1K5. Positions 12-355.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0710.

Proteomic databases

PRIDEi Q8G1K5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29639 ; AAN29639 ; BR0710 .
AEM18056 ; AEM18056 ; BS1330_I0706 .
GeneIDi 1166373.
12137027.
KEGGi bms:BR0710.
bsi:BS1330_I0706.
PATRICi 17789713. VBIBruSui107850_0723.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .

Miscellaneous databases

PROi Q8G1K5.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiPUR5_BRUSU
AccessioniPrimary (citable) accession number: Q8G1K5
Secondary accession number(s): G0K8C9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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