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Q8G1A7

- NUOK_BRUSU

UniProt

Q8G1A7 - NUOK_BRUSU

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Protein

NADH-quinone oxidoreductase subunit K

Gene

nuoK

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NADH + quinone = NAD+ + quinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. ATP synthesis coupled electron transport Source: InterPro
  2. transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Transport

Keywords - Ligandi

NAD, Ubiquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NADH-quinone oxidoreductase subunit KUniRule annotation (EC:1.6.99.5UniRule annotation)
Alternative name(s):
NADH dehydrogenase I subunit KUniRule annotation
NDH-1 subunit KUniRule annotation
Gene namesi
Name:nuoKUniRule annotation
Ordered Locus Names:BR0812, BS1330_I0808
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalUniRule annotationAdd
BLAST
Transmembranei31 – 5121HelicalUniRule annotationAdd
BLAST
Transmembranei66 – 8621HelicalUniRule annotationAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 102102NADH-quinone oxidoreductase subunit KPRO_0000389977Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Subunit structurei

NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR0812.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4L family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0713.
HOGENOMiHOG000066429.
KOiK00340.
OMAiVEDINMM.
OrthoDBiEOG6MSS3R.

Family and domain databases

HAMAPiMF_01456. NDH1_NuoK.
InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view]
PANTHERiPTHR11434. PTHR11434. 1 hit.
PfamiPF00420. Oxidored_q2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G1A7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIGIAHYLT VSAILFTLGV FGIFLNRKNV IVILMSIELI LLSVNLNFVA
60 70 80 90 100
FSSQLGDLVG QVFALFVLTV AAAEAAIGLA ILVVFFRNRG SIAVEDVNVM

KG
Length:102
Mass (Da):10,942
Last modified:March 1, 2003 - v1
Checksum:iE3EC572231BD3204
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29741.1.
CP002997 Genomic DNA. Translation: AEM18158.1.
PIRiAF3395.
RefSeqiNP_697826.1. NC_004310.3.
YP_005615650.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29741; AAN29741; BR0812.
AEM18158; AEM18158; BS1330_I0808.
GeneIDi1166480.
12137134.
KEGGibms:BR0812.
bsi:BS1330_I0808.
PATRICi17789922. VBIBruSui107850_0822.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29741.1 .
CP002997 Genomic DNA. Translation: AEM18158.1 .
PIRi AF3395.
RefSeqi NP_697826.1. NC_004310.3.
YP_005615650.1. NC_017251.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0812.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29741 ; AAN29741 ; BR0812 .
AEM18158 ; AEM18158 ; BS1330_I0808 .
GeneIDi 1166480.
12137134.
KEGGi bms:BR0812.
bsi:BS1330_I0808.
PATRICi 17789922. VBIBruSui107850_0822.

Phylogenomic databases

eggNOGi COG0713.
HOGENOMi HOG000066429.
KOi K00340.
OMAi VEDINMM.
OrthoDBi EOG6MSS3R.

Family and domain databases

HAMAPi MF_01456. NDH1_NuoK.
InterProi IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
[Graphical view ]
PANTHERi PTHR11434. PTHR11434. 1 hit.
Pfami PF00420. Oxidored_q2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiNUOK_BRUSU
AccessioniPrimary (citable) accession number: Q8G1A7
Secondary accession number(s): G0K8W0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3