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Q8G1A7

- NUOK_BRUSU

UniProt

Q8G1A7 - NUOK_BRUSU

Protein

NADH-quinone oxidoreductase subunit K

Gene

nuoK

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (quinone) activity Source: UniProtKB-HAMAP
    2. quinone binding Source: UniProtKB-KW

    GO - Biological processi

    1. ATP synthesis coupled electron transport Source: InterPro
    2. transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Transport

    Keywords - Ligandi

    NAD, Ubiquinone

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit KUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit KUniRule annotation
    NDH-1 subunit KUniRule annotation
    Gene namesi
    Name:nuoKUniRule annotation
    Ordered Locus Names:BR0812, BS1330_I0808
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell inner membrane, Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 102102NADH-quinone oxidoreductase subunit KPRO_0000389977Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR0812.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalUniRule annotationAdd
    BLAST
    Transmembranei31 – 5121HelicalUniRule annotationAdd
    BLAST
    Transmembranei66 – 8621HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 4L family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0713.
    HOGENOMiHOG000066429.
    KOiK00340.
    OMAiVEDINMM.
    OrthoDBiEOG6MSS3R.

    Family and domain databases

    HAMAPiMF_01456. NDH1_NuoK.
    InterProiIPR001133. NADH_UbQ_OxRdtase_chain4L/K.
    [Graphical view]
    PANTHERiPTHR11434. PTHR11434. 1 hit.
    PfamiPF00420. Oxidored_q2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G1A7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIGIAHYLT VSAILFTLGV FGIFLNRKNV IVILMSIELI LLSVNLNFVA    50
    FSSQLGDLVG QVFALFVLTV AAAEAAIGLA ILVVFFRNRG SIAVEDVNVM 100
    KG 102
    Length:102
    Mass (Da):10,942
    Last modified:March 1, 2003 - v1
    Checksum:iE3EC572231BD3204
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29741.1.
    CP002997 Genomic DNA. Translation: AEM18158.1.
    PIRiAF3395.
    RefSeqiNP_697826.1. NC_004310.3.
    YP_005615650.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29741; AAN29741; BR0812.
    AEM18158; AEM18158; BS1330_I0808.
    GeneIDi1166480.
    12137134.
    KEGGibms:BR0812.
    bsi:BS1330_I0808.
    PATRICi17789922. VBIBruSui107850_0822.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29741.1 .
    CP002997 Genomic DNA. Translation: AEM18158.1 .
    PIRi AF3395.
    RefSeqi NP_697826.1. NC_004310.3.
    YP_005615650.1. NC_017251.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0812.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29741 ; AAN29741 ; BR0812 .
    AEM18158 ; AEM18158 ; BS1330_I0808 .
    GeneIDi 1166480.
    12137134.
    KEGGi bms:BR0812.
    bsi:BS1330_I0808.
    PATRICi 17789922. VBIBruSui107850_0822.

    Phylogenomic databases

    eggNOGi COG0713.
    HOGENOMi HOG000066429.
    KOi K00340.
    OMAi VEDINMM.
    OrthoDBi EOG6MSS3R.

    Family and domain databases

    HAMAPi MF_01456. NDH1_NuoK.
    InterProi IPR001133. NADH_UbQ_OxRdtase_chain4L/K.
    [Graphical view ]
    PANTHERi PTHR11434. PTHR11434. 1 hit.
    Pfami PF00420. Oxidored_q2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiNUOK_BRUSU
    AccessioniPrimary (citable) accession number: Q8G1A7
    Secondary accession number(s): G0K8W0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 2009
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3