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Q8G189

- TTCA_BRUSU

UniProt

Q8G189 - TTCA_BRUSU

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Protein
tRNA 2-thiocytidine biosynthesis protein TtcA
Gene
ttcA, BR0831, BS1330_I0827
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s2C32) By similarity.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 676ATP Reviewed prediction

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA processing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA 2-thiocytidine biosynthesis protein TtcA
Gene namesi
Name:ttcA
Ordered Locus Names:BR0831, BS1330_I0827
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293tRNA 2-thiocytidine biosynthesis protein TtcAUniRule annotation
PRO_0000348677Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR0831.

Structurei

3D structure databases

ProteinModelPortaliQ8G189.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi137 – 1404CXXCUniRule annotation
Motifi225 – 2284CXXCUniRule annotation

Sequence similaritiesi

Belongs to the TtcA family.

Phylogenomic databases

eggNOGiCOG0037.
HOGENOMiHOG000013323.
KOiK14058.
OMAiCKEKDIE.
OrthoDBiEOG60KN2F.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01850. TtcA.
InterProiIPR012089. 2-thiocytidine_tRNA_synth_TtcA.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011063. tRNA-lysidine/thiocyt_synth.
[Graphical view]
PfamiPF01171. ATP_bind_3. 1 hit.
[Graphical view]
PIRSFiPIRSF004976. ATPase_YdaO. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G189-1 [UniParc]FASTAAdd to Basket

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MNAFDADITE HADSSGCHPL FRDVPATVEF NKLRKRLLRL TRQAIEDFAM    50
VKPGDRWMVC LSGGKDSYGL LALLLDLKWR GLLPVELLAV NLDQGQPNFP 100
KHILPDFLTR YGIEHRIEYQ DTYSIVTDKL PETSTYCSLC SRLRRGNLYR 150
IAREEGCSAI VLGHHREDIL ETFFMNLFHG GRLAAMPPKL LNDEGDLMVF 200
RPLAYAAEDD LEKFANAMQF PIIPCDLCGS QDGLQRNAMK AMLIDIEKRM 250
PGRKDTMIRA LTNVRPSHLL DRKLFDFAGL MANGEKGSDD ALW 293
Length:293
Mass (Da):33,259
Last modified:March 1, 2003 - v1
Checksum:i39AA1E5ECF5898F7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29760.1.
CP002997 Genomic DNA. Translation: AEM18177.1.
RefSeqiNP_697845.1. NC_004310.3.
YP_005615669.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29760; AAN29760; BR0831.
AEM18177; AEM18177; BS1330_I0827.
GeneIDi1166499.
12137153.
KEGGibms:BR0831.
bsi:BS1330_I0827.
PATRICi17789964. VBIBruSui107850_0843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29760.1 .
CP002997 Genomic DNA. Translation: AEM18177.1 .
RefSeqi NP_697845.1. NC_004310.3.
YP_005615669.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G189.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0831.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29760 ; AAN29760 ; BR0831 .
AEM18177 ; AEM18177 ; BS1330_I0827 .
GeneIDi 1166499.
12137153.
KEGGi bms:BR0831.
bsi:BS1330_I0827.
PATRICi 17789964. VBIBruSui107850_0843.

Phylogenomic databases

eggNOGi COG0037.
HOGENOMi HOG000013323.
KOi K14058.
OMAi CKEKDIE.
OrthoDBi EOG60KN2F.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_01850. TtcA.
InterProi IPR012089. 2-thiocytidine_tRNA_synth_TtcA.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011063. tRNA-lysidine/thiocyt_synth.
[Graphical view ]
Pfami PF01171. ATP_bind_3. 1 hit.
[Graphical view ]
PIRSFi PIRSF004976. ATPase_YdaO. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiTTCA_BRUSU
AccessioniPrimary (citable) accession number: Q8G189
Secondary accession number(s): G0K8X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi