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Q8G189 (TTCA_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
tRNA 2-thiocytidine biosynthesis protein TtcA
Gene names
Name:ttcA
Ordered Locus Names:BR0831, BS1330_I0827
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length293 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s2C32) By similarity. HAMAP-Rule MF_01850

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_01850.

Sequence similarities

Belongs to the TtcA family.

Ontologies

Keywords
   Biological processtRNA processing
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtRNA processing

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 293293tRNA 2-thiocytidine biosynthesis protein TtcA HAMAP-Rule MF_01850
PRO_0000348677

Regions

Nucleotide binding62 – 676ATP Potential
Motif137 – 1404CXXC HAMAP-Rule MF_01850
Motif225 – 2284CXXC HAMAP-Rule MF_01850

Sequences

Sequence LengthMass (Da)Tools
Q8G189 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 39AA1E5ECF5898F7

FASTA29333,259
        10         20         30         40         50         60 
MNAFDADITE HADSSGCHPL FRDVPATVEF NKLRKRLLRL TRQAIEDFAM VKPGDRWMVC 

        70         80         90        100        110        120 
LSGGKDSYGL LALLLDLKWR GLLPVELLAV NLDQGQPNFP KHILPDFLTR YGIEHRIEYQ 

       130        140        150        160        170        180 
DTYSIVTDKL PETSTYCSLC SRLRRGNLYR IAREEGCSAI VLGHHREDIL ETFFMNLFHG 

       190        200        210        220        230        240 
GRLAAMPPKL LNDEGDLMVF RPLAYAAEDD LEKFANAMQF PIIPCDLCGS QDGLQRNAMK 

       250        260        270        280        290 
AMLIDIEKRM PGRKDTMIRA LTNVRPSHLL DRKLFDFAGL MANGEKGSDD ALW 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN29760.1.
CP002997 Genomic DNA. Translation: AEM18177.1.
RefSeqNP_697845.1. NC_004310.3.
YP_005615669.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G189.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR0831.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN29760; AAN29760; BR0831.
AEM18177; AEM18177; BS1330_I0827.
GeneID1166499.
12137153.
KEGGbms:BR0831.
bsi:BS1330_I0827.
PATRIC17789964. VBIBruSui107850_0843.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0037.
HOGENOMHOG000013323.
KOK14058.
OMAPLAYCKE.
OrthoDBEOG60KN2F.
ProtClustDBPRK10696.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
HAMAPMF_01850. TtcA.
InterProIPR012089. 2-thiocytidine_tRNA_synth_TtcA.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011063. tRNA-lysidine/thiocyt_synth.
[Graphical view]
PfamPF01171. ATP_bind_3. 1 hit.
[Graphical view]
PIRSFPIRSF004976. ATPase_YdaO. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTTCA_BRUSU
AccessionPrimary (citable) accession number: Q8G189
Secondary accession number(s): G0K8X9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names