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Protein

tRNA 2-thiocytidine biosynthesis protein TtcA

Gene

ttcA

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s2C32).UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 676ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. tRNA processing Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA 2-thiocytidine biosynthesis protein TtcAUniRule annotation
Gene namesi
Name:ttcAUniRule annotation
Ordered Locus Names:BR0831, BS1330_I0827
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 293293tRNA 2-thiocytidine biosynthesis protein TtcAPRO_0000348677Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR0831.

Structurei

3D structure databases

ProteinModelPortaliQ8G189.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi137 – 1404CXXC
Motifi225 – 2284CXXC

Sequence similaritiesi

Belongs to the TtcA family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0037.
HOGENOMiHOG000013323.
KOiK14058.
OMAiEHILPEY.
OrthoDBiEOG60KN2F.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01850. TtcA.
InterProiIPR012089. 2-thiocytidine_tRNA_synth_TtcA.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011063. tRNA-lysidine/thiocyt_synth.
[Graphical view]
PfamiPF01171. ATP_bind_3. 1 hit.
[Graphical view]
PIRSFiPIRSF004976. ATPase_YdaO. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G189-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAFDADITE HADSSGCHPL FRDVPATVEF NKLRKRLLRL TRQAIEDFAM
60 70 80 90 100
VKPGDRWMVC LSGGKDSYGL LALLLDLKWR GLLPVELLAV NLDQGQPNFP
110 120 130 140 150
KHILPDFLTR YGIEHRIEYQ DTYSIVTDKL PETSTYCSLC SRLRRGNLYR
160 170 180 190 200
IAREEGCSAI VLGHHREDIL ETFFMNLFHG GRLAAMPPKL LNDEGDLMVF
210 220 230 240 250
RPLAYAAEDD LEKFANAMQF PIIPCDLCGS QDGLQRNAMK AMLIDIEKRM
260 270 280 290
PGRKDTMIRA LTNVRPSHLL DRKLFDFAGL MANGEKGSDD ALW
Length:293
Mass (Da):33,259
Last modified:March 1, 2003 - v1
Checksum:i39AA1E5ECF5898F7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29760.1.
CP002997 Genomic DNA. Translation: AEM18177.1.
RefSeqiNP_697845.1. NC_004310.3.
YP_005615669.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29760; AAN29760; BR0831.
AEM18177; AEM18177; BS1330_I0827.
GeneIDi1166499.
12137153.
KEGGibms:BR0831.
bsi:BS1330_I0827.
PATRICi17789964. VBIBruSui107850_0843.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29760.1.
CP002997 Genomic DNA. Translation: AEM18177.1.
RefSeqiNP_697845.1. NC_004310.3.
YP_005615669.1. NC_017251.1.

3D structure databases

ProteinModelPortaliQ8G189.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204722.BR0831.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN29760; AAN29760; BR0831.
AEM18177; AEM18177; BS1330_I0827.
GeneIDi1166499.
12137153.
KEGGibms:BR0831.
bsi:BS1330_I0827.
PATRICi17789964. VBIBruSui107850_0843.

Phylogenomic databases

eggNOGiCOG0037.
HOGENOMiHOG000013323.
KOiK14058.
OMAiEHILPEY.
OrthoDBiEOG60KN2F.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_01850. TtcA.
InterProiIPR012089. 2-thiocytidine_tRNA_synth_TtcA.
IPR014729. Rossmann-like_a/b/a_fold.
IPR011063. tRNA-lysidine/thiocyt_synth.
[Graphical view]
PfamiPF01171. ATP_bind_3. 1 hit.
[Graphical view]
PIRSFiPIRSF004976. ATPase_YdaO. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiTTCA_BRUSU
AccessioniPrimary (citable) accession number: Q8G189
Secondary accession number(s): G0K8X9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: March 1, 2003
Last modified: January 7, 2015
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.