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Q8G0Z4

- NADK_BRUSU

UniProt

Q8G0Z4 - NADK_BRUSU

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Protein
NAD kinase
Gene
nadK, BR0937, BS1330_I0933
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

Divalent metal ions By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei46 – 461Proton acceptor By similarity
Binding sitei146 – 1461NAD By similarity
Binding sitei154 – 1541NAD; via carbonyl oxygen By similarity
Binding sitei218 – 2181NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi46 – 472NAD By similarity
Nucleotide bindingi116 – 1172NAD By similarity
Nucleotide bindingi157 – 1626NAD By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. NAD+ kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. NAD metabolic process Source: InterPro
  2. NADP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinase (EC:2.7.1.23)
Alternative name(s):
ATP-dependent NAD kinase
Gene namesi
Name:nadK
Ordered Locus Names:BR0937, BS1330_I0933
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 257257NAD kinaseUniRule annotation
PRO_0000120604Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR0937.

Structurei

3D structure databases

ProteinModelPortaliQ8G0Z4.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.

Phylogenomic databases

eggNOGiCOG0061.
HOGENOMiHOG000139847.
KOiK00858.
OrthoDBiEOG6PZXDR.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMiSSF111331. SSF111331. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G0Z4-1 [UniParc]FASTAAdd to Basket

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MKDTSLALHF VSSGTKESLS AQKDLVERYG HVAAEDADII VALGGDGTML    50
QALRDFMNTG KPIYGMNRGS VGFLMNEFVI ENLPERILAA QMETIRPLVM 100
VAETEDAPPV EALAINEVSL FRQSYQAARI RITIDGKVRL QELVCDGVMV 150
ATPAGSTAYN LSAQGPILPL EAPLLALTPV SPFRPRRWGG ALLPKHVTVR 200
MDLLETEKRP VNAVADNNEV KSVTSVTVRE APNSQVTILF DKNHSWDERI 250
LTEQFRH 257
Length:257
Mass (Da):28,275
Last modified:November 7, 2003 - v2
Checksum:i54ACA8EF3504F74A
GO

Sequence cautioni

The sequence AAN29863.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
The sequence AEM18280.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29863.1. Different initiation.
CP002997 Genomic DNA. Translation: AEM18280.1. Different initiation.
RefSeqiNP_697948.1. NC_004310.3.
YP_005615772.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29863; AAN29863; BR0937.
AEM18280; AEM18280; BS1330_I0933.
GeneIDi1166607.
12137960.
KEGGibms:BR0937.
bsi:BS1330_I0933.
PATRICi17790186. VBIBruSui107850_0952.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29863.1 . Different initiation.
CP002997 Genomic DNA. Translation: AEM18280.1 . Different initiation.
RefSeqi NP_697948.1. NC_004310.3.
YP_005615772.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G0Z4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 204722.BR0937.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29863 ; AAN29863 ; BR0937 .
AEM18280 ; AEM18280 ; BS1330_I0933 .
GeneIDi 1166607.
12137960.
KEGGi bms:BR0937.
bsi:BS1330_I0933.
PATRICi 17790186. VBIBruSui107850_0952.

Phylogenomic databases

eggNOGi COG0061.
HOGENOMi HOG000139847.
KOi K00858.
OrthoDBi EOG6PZXDR.

Family and domain databases

Gene3Di 2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPi MF_00361. NAD_kinase.
InterProi IPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view ]
PANTHERi PTHR20275. PTHR20275. 1 hit.
Pfami PF01513. NAD_kinase. 1 hit.
[Graphical view ]
SUPFAMi SSF111331. SSF111331. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiNADK_BRUSU
AccessioniPrimary (citable) accession number: Q8G0Z4
Secondary accession number(s): G0K9L4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 7, 2003
Last modified: July 9, 2014
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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