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Q8G0Y6

- BEPC_BRUSU

UniProt

Q8G0Y6 - BEPC_BRUSU

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Protein

Outer membrane efflux protein BepC

Gene

bepC

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host.1 Publication

GO - Molecular functioni

  1. transporter activity Source: InterPro

GO - Biological processi

  1. protein transport Source: InterPro
  2. response to antibiotic Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Outer membrane efflux protein BepC
Gene namesi
Name:bepC
Ordered Locus Names:BR0945, BS1330_I0941
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. cell outer membrane Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutation strongly affects resistance to bile salts and toxic chemicals, and significantly decreases the resistance to antibiotics such as erythromycin, ampicillin, tetracycline, and norfloxacin. The mutant also has attenuated effects in the mouse model of infection.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 456428Outer membrane efflux protein BepCPRO_0000390647Add
BLAST

Interactioni

Subunit structurei

Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepD and BepE or with BepF and BepG.2 Publications

Protein-protein interaction databases

STRINGi204722.BR0945.

Structurei

3D structure databases

ProteinModelPortaliQ8G0Y6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili312 – 34130Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiCOG1538.
HOGENOMiHOG000143761.
KOiK12340.
OMAiYITITEA.
OrthoDBiEOG60KN0B.

Family and domain databases

InterProiIPR003423. OMP_efflux.
IPR010130. T1SS_OMP_TolC.
[Graphical view]
PANTHERiPTHR30026:SF3. PTHR30026:SF3. 1 hit.
PfamiPF02321. OEP. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01844. type_I_sec_TolC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8G0Y6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRYTVFKACK ELVAAAVLLS GTVLTGQAAL SETLTGALVK AYKNNAPLNS
60 70 80 90 100
SRAGVRIQDE NVAIAKSAYR PQITGSYNIS RGKTPATDYR TTGTVGIQLN
110 120 130 140 150
QMLFDGFQTR NNVAAAETQV FAQRENLRND EQNTLYQAVA AYMDVYQLRQ
160 170 180 190 200
IAALREKNLA AMNEQVRAAR ARLDVGEGTR TDVAQAEASR STAIAALNAA
210 220 230 240 250
RADVKTAEAT YMQVVGSLPD KLTPASAARH LPQSPSQAYA SALASHPGIL
260 270 280 290 300
ATKYAVNAAG YNVKAKEGAL LPTIGLTASA SQLDTIAGTD MGDGNTASIG
310 320 330 340 350
VGVNIPIYTG GRTSAQIRQS KEQLGQARIE VDVVQDKVRQ AISSAWSQLE
360 370 380 390 400
AARASVAANR DGIAAAQLAL DGVIEERKVG QRTTLDVLNA QNDLVAVQIA
410 420 430 440 450
LVQAEHDVVV ASYALLNATG RMTADQLGLQ VAQYKPEEHY KAVKDKWFGL

RTPDGR
Length:456
Mass (Da):48,518
Last modified:March 1, 2003 - v1
Checksum:i3CF3CBED5639292B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29871.1.
CP002997 Genomic DNA. Translation: AEM18288.1.
RefSeqiNP_697956.1. NC_004310.3.
YP_005615780.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29871; AAN29871; BR0945.
AEM18288; AEM18288; BS1330_I0941.
GeneIDi1166615.
12137968.
KEGGibms:BR0945.
bsi:BS1330_I0941.
PATRICi17790200. VBIBruSui107850_0959.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN29871.1 .
CP002997 Genomic DNA. Translation: AEM18288.1 .
RefSeqi NP_697956.1. NC_004310.3.
YP_005615780.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G0Y6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0945.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29871 ; AAN29871 ; BR0945 .
AEM18288 ; AEM18288 ; BS1330_I0941 .
GeneIDi 1166615.
12137968.
KEGGi bms:BR0945.
bsi:BS1330_I0941.
PATRICi 17790200. VBIBruSui107850_0959.

Phylogenomic databases

eggNOGi COG1538.
HOGENOMi HOG000143761.
KOi K12340.
OMAi YITITEA.
OrthoDBi EOG60KN0B.

Family and domain databases

InterProi IPR003423. OMP_efflux.
IPR010130. T1SS_OMP_TolC.
[Graphical view ]
PANTHERi PTHR30026:SF3. PTHR30026:SF3. 1 hit.
Pfami PF02321. OEP. 2 hits.
[Graphical view ]
TIGRFAMsi TIGR01844. type_I_sec_TolC. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. "The TolC homologue of Brucella suis is involved in resistance to antimicrobial compounds and virulence."
    Posadas D.M., Martin F.A., Sabio y Garcia J.V., Spera J.M., Delpino M.V., Baldi P., Campos E., Cravero S.L., Zorreguieta A.
    Infect. Immun. 75:379-389(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBUNIT, DISRUPTION PHENOTYPE.
    Strain: 1330.
  4. "Interplay between two RND systems mediating antimicrobial resistance in Brucella suis."
    Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D., Zorreguieta A.
    J. Bacteriol. 191:2530-2540(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBUNIT.
    Strain: 1330.

Entry informationi

Entry nameiBEPC_BRUSU
AccessioniPrimary (citable) accession number: Q8G0Y6
Secondary accession number(s): G0K9M2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3