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Q8G0Y6

- BEPC_BRUSU

UniProt

Q8G0Y6 - BEPC_BRUSU

Protein

Outer membrane efflux protein BepC

Gene

bepC

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host.1 Publication

    GO - Molecular functioni

    1. transporter activity Source: InterPro

    GO - Biological processi

    1. protein transport Source: InterPro
    2. response to antibiotic Source: UniProtKB-KW

    Keywords - Biological processi

    Antibiotic resistance, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Outer membrane efflux protein BepC
    Gene namesi
    Name:bepC
    Ordered Locus Names:BR0945, BS1330_I0941
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. cell outer membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Cell outer membrane, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mutation strongly affects resistance to bile salts and toxic chemicals, and significantly decreases the resistance to antibiotics such as erythromycin, ampicillin, tetracycline, and norfloxacin. The mutant also has attenuated effects in the mouse model of infection.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 456428Outer membrane efflux protein BepCPRO_0000390647Add
    BLAST

    Interactioni

    Subunit structurei

    Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepD and BepE or with BepF and BepG.2 Publications

    Protein-protein interaction databases

    STRINGi204722.BR0945.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G0Y6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili312 – 34130Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Coiled coil, Signal, Transmembrane, Transmembrane beta strand

    Phylogenomic databases

    eggNOGiCOG1538.
    HOGENOMiHOG000143761.
    KOiK12340.
    OMAiYITITEA.
    OrthoDBiEOG60KN0B.

    Family and domain databases

    InterProiIPR003423. OMP_efflux.
    IPR010130. T1SS_OMP_TolC.
    [Graphical view]
    PfamiPF02321. OEP. 2 hits.
    [Graphical view]
    TIGRFAMsiTIGR01844. type_I_sec_TolC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8G0Y6-1 [UniParc]FASTAAdd to Basket

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    MRYTVFKACK ELVAAAVLLS GTVLTGQAAL SETLTGALVK AYKNNAPLNS    50
    SRAGVRIQDE NVAIAKSAYR PQITGSYNIS RGKTPATDYR TTGTVGIQLN 100
    QMLFDGFQTR NNVAAAETQV FAQRENLRND EQNTLYQAVA AYMDVYQLRQ 150
    IAALREKNLA AMNEQVRAAR ARLDVGEGTR TDVAQAEASR STAIAALNAA 200
    RADVKTAEAT YMQVVGSLPD KLTPASAARH LPQSPSQAYA SALASHPGIL 250
    ATKYAVNAAG YNVKAKEGAL LPTIGLTASA SQLDTIAGTD MGDGNTASIG 300
    VGVNIPIYTG GRTSAQIRQS KEQLGQARIE VDVVQDKVRQ AISSAWSQLE 350
    AARASVAANR DGIAAAQLAL DGVIEERKVG QRTTLDVLNA QNDLVAVQIA 400
    LVQAEHDVVV ASYALLNATG RMTADQLGLQ VAQYKPEEHY KAVKDKWFGL 450
    RTPDGR 456
    Length:456
    Mass (Da):48,518
    Last modified:March 1, 2003 - v1
    Checksum:i3CF3CBED5639292B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29871.1.
    CP002997 Genomic DNA. Translation: AEM18288.1.
    RefSeqiNP_697956.1. NC_004310.3.
    YP_005615780.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29871; AAN29871; BR0945.
    AEM18288; AEM18288; BS1330_I0941.
    GeneIDi1166615.
    12137968.
    KEGGibms:BR0945.
    bsi:BS1330_I0941.
    PATRICi17790200. VBIBruSui107850_0959.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29871.1 .
    CP002997 Genomic DNA. Translation: AEM18288.1 .
    RefSeqi NP_697956.1. NC_004310.3.
    YP_005615780.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G0Y6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR0945.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29871 ; AAN29871 ; BR0945 .
    AEM18288 ; AEM18288 ; BS1330_I0941 .
    GeneIDi 1166615.
    12137968.
    KEGGi bms:BR0945.
    bsi:BS1330_I0941.
    PATRICi 17790200. VBIBruSui107850_0959.

    Phylogenomic databases

    eggNOGi COG1538.
    HOGENOMi HOG000143761.
    KOi K12340.
    OMAi YITITEA.
    OrthoDBi EOG60KN0B.

    Family and domain databases

    InterProi IPR003423. OMP_efflux.
    IPR010130. T1SS_OMP_TolC.
    [Graphical view ]
    Pfami PF02321. OEP. 2 hits.
    [Graphical view ]
    TIGRFAMsi TIGR01844. type_I_sec_TolC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    3. "The TolC homologue of Brucella suis is involved in resistance to antimicrobial compounds and virulence."
      Posadas D.M., Martin F.A., Sabio y Garcia J.V., Spera J.M., Delpino M.V., Baldi P., Campos E., Cravero S.L., Zorreguieta A.
      Infect. Immun. 75:379-389(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBUNIT, DISRUPTION PHENOTYPE.
      Strain: 1330.
    4. "Interplay between two RND systems mediating antimicrobial resistance in Brucella suis."
      Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D., Zorreguieta A.
      J. Bacteriol. 191:2530-2540(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBUNIT.
      Strain: 1330.

    Entry informationi

    Entry nameiBEPC_BRUSU
    AccessioniPrimary (citable) accession number: Q8G0Y6
    Secondary accession number(s): G0K9M2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3