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Q8G0Y6 (BEPC_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Outer membrane efflux protein BepC
Gene names
Name:bepC
Ordered Locus Names:BR0945, BS1330_I0941
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length456 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in the efflux of toxic and relatively hydrophobic compounds. Influences survival inside the host. Ref.3

Subunit structure

Probably part of a tripartite efflux pump, which is composed of an outer membrane efflux protein, an inner membrane protein and a protein that expands the periplasmic space. Could form a tripartite pump with BepD and BepE or with BepF and BepG. Ref.3 Ref.4

Subcellular location

Cell outer membrane Probable.

Disruption phenotype

Mutation strongly affects resistance to bile salts and toxic chemicals, and significantly decreases the resistance to antibiotics such as erythromycin, ampicillin, tetracycline, and norfloxacin. The mutant also has attenuated effects in the mouse model of infection. Ref.3

Sequence similarities

Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. [View classification]

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 456428Outer membrane efflux protein BepC
PRO_0000390647

Regions

Coiled coil312 – 34130 Potential

Sequences

Sequence LengthMass (Da)Tools
Q8G0Y6 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 3CF3CBED5639292B

FASTA45648,518
        10         20         30         40         50         60 
MRYTVFKACK ELVAAAVLLS GTVLTGQAAL SETLTGALVK AYKNNAPLNS SRAGVRIQDE 

        70         80         90        100        110        120 
NVAIAKSAYR PQITGSYNIS RGKTPATDYR TTGTVGIQLN QMLFDGFQTR NNVAAAETQV 

       130        140        150        160        170        180 
FAQRENLRND EQNTLYQAVA AYMDVYQLRQ IAALREKNLA AMNEQVRAAR ARLDVGEGTR 

       190        200        210        220        230        240 
TDVAQAEASR STAIAALNAA RADVKTAEAT YMQVVGSLPD KLTPASAARH LPQSPSQAYA 

       250        260        270        280        290        300 
SALASHPGIL ATKYAVNAAG YNVKAKEGAL LPTIGLTASA SQLDTIAGTD MGDGNTASIG 

       310        320        330        340        350        360 
VGVNIPIYTG GRTSAQIRQS KEQLGQARIE VDVVQDKVRQ AISSAWSQLE AARASVAANR 

       370        380        390        400        410        420 
DGIAAAQLAL DGVIEERKVG QRTTLDVLNA QNDLVAVQIA LVQAEHDVVV ASYALLNATG 

       430        440        450 
RMTADQLGLQ VAQYKPEEHY KAVKDKWFGL RTPDGR 

« Hide

References

« Hide 'large scale' references
[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[3]"The TolC homologue of Brucella suis is involved in resistance to antimicrobial compounds and virulence."
Posadas D.M., Martin F.A., Sabio y Garcia J.V., Spera J.M., Delpino M.V., Baldi P., Campos E., Cravero S.L., Zorreguieta A.
Infect. Immun. 75:379-389(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBUNIT, DISRUPTION PHENOTYPE.
Strain: 1330.
[4]"Interplay between two RND systems mediating antimicrobial resistance in Brucella suis."
Martin F.A., Posadas D.M., Carrica M.C., Cravero S.L., O'Callaghan D., Zorreguieta A.
J. Bacteriol. 191:2530-2540(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBUNIT.
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN29871.1.
CP002997 Genomic DNA. Translation: AEM18288.1.
RefSeqNP_697956.1. NC_004310.3.
YP_005615780.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G0Y6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR0945.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN29871; AAN29871; BR0945.
AEM18288; AEM18288; BS1330_I0941.
GeneID1166615.
12137968.
KEGGbms:BR0945.
bsi:BS1330_I0941.
PATRIC17790200. VBIBruSui107850_0959.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1538.
HOGENOMHOG000143761.
KOK12340.
OMAYITITEA.
OrthoDBEOG60KN0B.

Family and domain databases

InterProIPR003423. OMP_efflux.
IPR010130. T1SS_OMP_TolC.
[Graphical view]
PfamPF02321. OEP. 2 hits.
[Graphical view]
TIGRFAMsTIGR01844. type_I_sec_TolC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameBEPC_BRUSU
AccessionPrimary (citable) accession number: Q8G0Y6
Secondary accession number(s): G0K9M2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names