Q8G0U3 (KTHY_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thymidylate kinase
EC=2.7.4.9

Alternative name(s):
dTMP kinase

Gene names

Name:	tmk
Ordered Locus Names:	BR0992, BS1330_I0988

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	214 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis By similarity. HAMAP-Rule MF_00165
Catalytic activity	ATP + dTMP = ADP + dTDP. HAMAP-Rule MF_00165
Sequence similarities	Belongs to the thymidylate kinase family.
Sequence caution	The sequence AAN29915.1 differs from that shown. Reason: Erroneous initiation. The sequence AEM18332.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Biological process	Nucleotide biosynthesis
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	dTDP biosynthetic process Inferred from electronic annotation. Source: InterPro dTTP biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	ATP binding Inferred from electronic annotation. Source: HAMAP thymidylate kinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 214	214	Thymidylate kinase HAMAP-Rule MF_00165		PRO_0000155248
Regions
	Nucleotide binding	10 – 17	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8G0U3 [UniParc]. Last modified October 31, 2003. Version 2. Checksum: CB4D9C1F4DF02E78	FASTA	214	23,141
	10 20 30 40 50 60 MSGLFITFEG GEGAGKSTQI ALLASHLRNH GFDPVITREP GGSPGAEAIR HVILSGNAET 70 80 90 100 110 120 YGPAMEALLF AAARADHVDQ LIRPALAEGR IVLCDRFIDS SRAYQGVTGN LDATYMAAIE 130 140 150 160 170 180 RIAIDGAMPD LTLVLDICAE RGLSRAGKRR GSDTADRFEK EDIAVHEARR QAFLEIARQE 190 200 210 PARCKVIDAD RSQEKIADEI RSVVDTILTE KGLL

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

[2]

"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014291 Genomic DNA. Translation: AAN29915.1. Different initiation. CP002997 Genomic DNA. Translation: AEM18332.1. Different initiation.
RefSeq	NP_698000.1. NC_004310.3. YP_005615824.1. NC_017251.1.
3D structure databases
ProteinModelPortal	Q8G0U3.
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BR0992.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN29915; AAN29915; BR0992. AEM18332; AEM18332; BS1330_I0988.
GeneID	1166665. 12138018.
KEGG	bms:BR0992. bsi:BS1330_I0988.
PATRIC	17790296. VBIBruSui107850_1004.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0125.
HOGENOM	HOG000229078.
KO	K00943.
ProtClustDB	PRK13973.
Family and domain databases
HAMAP	MF_00165. Thymidylate_kinase.
InterPro	IPR018095. Thymidylate_kin_CS. IPR018094. Thymidylate_kinase. [Graphical view]
PANTHER	PTHR10344. PTHR10344. 1 hit.
TIGRFAMs	TIGR00041. DTMP_kinase. 1 hit.
PROSITE	PS01331. THYMIDYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

KTHY_BRUSU

Accession

Primary (citable) accession number: Q8G0U3
Secondary accession number(s): G0K9R6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	October 31, 2003
Last modified:	May 1, 2013
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program