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Q8G0U3

- KTHY_BRUSU

UniProt

Q8G0U3 - KTHY_BRUSU

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Protein

Thymidylate kinase

Gene

tmk

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.UniRule annotation

Catalytic activityi

ATP + dTMP = ADP + dTDP.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 178ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidylate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTDP biosynthetic process Source: InterPro
  2. dTTP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinaseUniRule annotation (EC:2.7.4.9UniRule annotation)
Alternative name(s):
dTMP kinaseUniRule annotation
Gene namesi
Name:tmkUniRule annotation
Ordered Locus Names:BR0992, BS1330_I0988
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 214214Thymidylate kinasePRO_0000155248Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR0992.

Structurei

3D structure databases

ProteinModelPortaliQ8G0U3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0125.
HOGENOMiHOG000229078.
KOiK00943.
OrthoDBiEOG64JFSH.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G0U3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGLFITFEG GEGAGKSTQI ALLASHLRNH GFDPVITREP GGSPGAEAIR
60 70 80 90 100
HVILSGNAET YGPAMEALLF AAARADHVDQ LIRPALAEGR IVLCDRFIDS
110 120 130 140 150
SRAYQGVTGN LDATYMAAIE RIAIDGAMPD LTLVLDICAE RGLSRAGKRR
160 170 180 190 200
GSDTADRFEK EDIAVHEARR QAFLEIARQE PARCKVIDAD RSQEKIADEI
210
RSVVDTILTE KGLL
Length:214
Mass (Da):23,141
Last modified:October 31, 2003 - v2
Checksum:iCB4D9C1F4DF02E78
GO

Sequence cautioni

The sequence AAN29915.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence AEM18332.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29915.1. Different initiation.
CP002997 Genomic DNA. Translation: AEM18332.1. Different initiation.
RefSeqiNP_698000.1. NC_004310.3.
YP_005615824.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN29915; AAN29915; BR0992.
AEM18332; AEM18332; BS1330_I0988.
GeneIDi1166665.
12138018.
KEGGibms:BR0992.
bsi:BS1330_I0988.
PATRICi17790296. VBIBruSui107850_1004.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN29915.1 . Different initiation.
CP002997 Genomic DNA. Translation: AEM18332.1 . Different initiation.
RefSeqi NP_698000.1. NC_004310.3.
YP_005615824.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G0U3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR0992.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN29915 ; AAN29915 ; BR0992 .
AEM18332 ; AEM18332 ; BS1330_I0988 .
GeneIDi 1166665.
12138018.
KEGGi bms:BR0992.
bsi:BS1330_I0988.
PATRICi 17790296. VBIBruSui107850_1004.

Phylogenomic databases

eggNOGi COG0125.
HOGENOMi HOG000229078.
KOi K00943.
OrthoDBi EOG64JFSH.

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00165. Thymidylate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00041. DTMP_kinase. 1 hit.
PROSITEi PS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiKTHY_BRUSU
AccessioniPrimary (citable) accession number: Q8G0U3
Secondary accession number(s): G0K9R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: October 31, 2003
Last modified: October 1, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3