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Q8G0S7 (RPIA_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribose-5-phosphate isomerase A

EC=5.3.1.6
Alternative name(s):
Phosphoriboisomerase A
Short name=PRI
Gene names
Name:rpiA
Ordered Locus Names:BR1010, BS1330_I1006
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length232 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate By similarity. HAMAP-Rule MF_00170

Catalytic activity

D-ribose 5-phosphate = D-ribulose 5-phosphate. HAMAP-Rule MF_00170

Pathway

Carbohydrate degradation; pentose phosphate pathway; D-ribose 5-phosphate from D-ribulose 5-phosphate (non-oxidative stage): step 1/1. HAMAP-Rule MF_00170

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00170

Sequence similarities

Belongs to the ribose 5-phosphate isomerase family.

Ontologies

Keywords
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processpentose-phosphate shunt, non-oxidative branch

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionribose-5-phosphate isomerase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 232232Ribose-5-phosphate isomerase A HAMAP-Rule MF_00170
PRO_0000158397

Regions

Region29 – 324Substrate binding By similarity
Region84 – 874Substrate binding By similarity
Region97 – 1004Substrate binding By similarity

Sites

Active site1061Proton acceptor By similarity
Binding site1241Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G0S7 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 44DB81829EA75C1E

FASTA23224,264
        10         20         30         40         50         60 
MDEARKLKIA AAAEALTYVK DGMRLGIGTG STAEEFVRLL AEKVKGGFRV IGVPTSERTA 

        70         80         90        100        110        120 
KLCEELGVAL TTLEETPHLD LTIDGADEVD GELSLIKGGG GALLREKIVA AASDSMIVIA 

       130        140        150        160        170        180 
DQSKVVETLG RFPLPIEVNR FGLGATIRAI EAAAVKCGLA GPLNLRLKDG SPFLTDGGHY 

       190        200        210        220        230 
IVDASFGRIP DPKTLSDALF AIPGVVEHGL FIGLARAAII AGTDGIRTMN RS 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN29932.1.
CP002997 Genomic DNA. Translation: AEM18350.1.
RefSeqNP_698017.1. NC_004310.3.
YP_005615842.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G0S7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR1010.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN29932; AAN29932; BR1010.
AEM18350; AEM18350; BS1330_I1006.
GeneID1166683.
12138036.
KEGGbms:BR1010.
bsi:BS1330_I1006.
PATRIC17790330. VBIBruSui107850_1021.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0120.
HOGENOMHOG000276369.
KOK01807.
OMAGACHVQE.
OrthoDBEOG67MF61.
ProtClustDBPRK00702.

Enzyme and pathway databases

UniPathwayUPA00115; UER00412.

Family and domain databases

HAMAPMF_00170. Rib_5P_isom_A.
InterProIPR004788. Ribose5P_isomerase_typA.
IPR020672. Ribose5P_isomerase_typA_subgr.
[Graphical view]
PANTHERPTHR11934. PTHR11934. 1 hit.
PfamPF06026. Rib_5-P_isom_A. 1 hit.
[Graphical view]
TIGRFAMsTIGR00021. rpiA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRPIA_BRUSU
AccessionPrimary (citable) accession number: Q8G0S7
Secondary accession number(s): G0K9T4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names