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Q8G0L3

- HIS3_BRUSU

UniProt

Q8G0L3 - HIS3_BRUSU

Protein

Phosphoribosyl-AMP cyclohydrolase

Gene

hisI

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.UniRule annotation

    Catalytic activityi

    1-(5-phospho-beta-D-ribosyl)-AMP + H2O = 1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation
    Binds 1 zinc ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi91 – 911MagnesiumUniRule annotation
    Metal bindingi92 – 921Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi93 – 931MagnesiumUniRule annotation
    Metal bindingi95 – 951MagnesiumUniRule annotation
    Metal bindingi110 – 1101Zinc; shared with dimeric partnerUniRule annotation
    Metal bindingi117 – 1171Zinc; shared with dimeric partnerUniRule annotation

    GO - Molecular functioni

    1. phosphoribosyl-AMP cyclohydrolase activity Source: UniProtKB-EC

    GO - Biological processi

    1. histidine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Amino-acid biosynthesis, Histidine biosynthesis

    Keywords - Ligandi

    Magnesium, Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00031; UER00008.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoribosyl-AMP cyclohydrolaseUniRule annotation (EC:3.5.4.19UniRule annotation)
    Short name:
    PRA-CHUniRule annotation
    Gene namesi
    Name:hisIUniRule annotation
    Ordered Locus Names:BR1076, BS1330_I1072
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 139139Phosphoribosyl-AMP cyclohydrolasePRO_0000136467Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR1076.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G0L3.
    SMRiQ8G0L3. Positions 18-124.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PRA-CH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0139.
    HOGENOMiHOG000277504.
    KOiK01496.
    OrthoDBiEOG6PGKB6.

    Family and domain databases

    HAMAPiMF_01021. HisI.
    InterProiIPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view]
    PfamiPF01502. PRA-CH. 1 hit.
    [Graphical view]
    ProDomiPD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q8G0L3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSIFPAQPSD KKAVEEGAAF MPRFDASGLI TAIVTDARDG ELLMVAHMNE    50
    EALRLTLETG IAHYWSRSRK TLWKKGETSG NLQSVVELRT DCDQDALWLK 100
    VHVAGDGPTC HTGRRSCFYR QVVSSGGKVA LTMVSDHDQ 139
    Length:139
    Mass (Da):15,308
    Last modified:November 7, 2003 - v2
    Checksum:iA150156774661556
    GO

    Sequence cautioni

    The sequence AAN29996.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29996.1. Different initiation.
    CP002997 Genomic DNA. Translation: AEM18414.1.
    RefSeqiNP_698081.2. NC_004310.3.
    YP_005615906.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN29996; AAN29996; BR1076.
    AEM18414; AEM18414; BS1330_I1072.
    GeneIDi1166750.
    12138103.
    KEGGibms:BR1076.
    bsi:BS1330_I1072.
    PATRICi17790470. VBIBruSui107850_1090.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN29996.1 . Different initiation.
    CP002997 Genomic DNA. Translation: AEM18414.1 .
    RefSeqi NP_698081.2. NC_004310.3.
    YP_005615906.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G0L3.
    SMRi Q8G0L3. Positions 18-124.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1076.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN29996 ; AAN29996 ; BR1076 .
    AEM18414 ; AEM18414 ; BS1330_I1072 .
    GeneIDi 1166750.
    12138103.
    KEGGi bms:BR1076.
    bsi:BS1330_I1072.
    PATRICi 17790470. VBIBruSui107850_1090.

    Phylogenomic databases

    eggNOGi COG0139.
    HOGENOMi HOG000277504.
    KOi K01496.
    OrthoDBi EOG6PGKB6.

    Enzyme and pathway databases

    UniPathwayi UPA00031 ; UER00008 .

    Family and domain databases

    HAMAPi MF_01021. HisI.
    InterProi IPR026660. PRA-CH.
    IPR002496. PRib_AMP_CycHydrolase_dom.
    [Graphical view ]
    Pfami PF01502. PRA-CH. 1 hit.
    [Graphical view ]
    ProDomi PD002610. PRA_CycHdrlase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiHIS3_BRUSU
    AccessioniPrimary (citable) accession number: Q8G0L3
    Secondary accession number(s): G0K9Z8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: November 7, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3