Q8G0J9 (PPI1_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable peptidyl-prolyl cis-trans isomerase
Short name=PPIase
EC=5.2.1.8

Alternative name(s):
Rotamase

Gene names

Name:	ppi
Ordered Locus Names:	BR1094, BS1330_I1090

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	196 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides By similarity.
Catalytic activity	Peptidylproline (omega=180) = peptidylproline (omega=0).
Subcellular location	Periplasm Potential.
Sequence similarities	Belongs to the cyclophilin-type PPIase family. Contains 1 PPIase cyclophilin-type domain.

Ontologies

Keywords
Cellular component	Periplasm
Domain	Signal
Molecular function	Isomerase Rotamase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	protein folding Inferred from electronic annotation. Source: UniProtKB-KW protein peptidyl-prolyl isomerization Inferred from electronic annotation. Source: GOC
Cellular_component	periplasmic space Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	peptidyl-prolyl cis-trans isomerase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 196	170	Probable peptidyl-prolyl cis-trans isomerase		PRO_0000282596
Regions
	Domain	29 – 194	166	PPIase cyclophilin-type

Sequences

	Sequence		Length	Mass (Da)
	Q8G0J9 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 5577F02D377FF89B	FASTA	196	20,751
	10 20 30 40 50 60 MSFIRSALAA AAFVALSIGA VQTASAADPE NTVILKLKDG DVALELRPDL APKHVAQIKK 70 80 90 100 110 120 LVREGAYNGV AFHRVIPGFM AQTGDVKFGN MDKGFDAARV GTGGSNYPDL PAEFSKEPFV 130 140 150 160 170 180 RGTVGMARSQ NPNSANSQFF IMFDDGPFLN GQYTVVGKVV SGMDAVDKIK KGSEAENGAV 190 KNPDKIIKAT IEADTK

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

[2]

"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014291 Genomic DNA. Translation: AAN30014.1. CP002997 Genomic DNA. Translation: AEM18432.1.
RefSeq	NP_698099.1. NC_004310.3. YP_005615924.1. NC_017251.1.
3D structure databases
HSSP	HSSP built from PDB template 2NUL based on UniProtKB P23869.
ProteinModelPortal	Q8G0J9.
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BR1094.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN30014; AAN30014; BR1094. AEM18432; AEM18432; BS1330_I1090.
GeneID	1166770. 12138123.
KEGG	bms:BR1094. bsi:BS1330_I1090.
PATRIC	17790522. VBIBruSui107850_1115.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0652.
HOGENOM	HOG000065981.
KO	K01802.
OMA	IMVADAD.
ProtClustDB	CLSK898243.
Family and domain databases
InterPro	IPR002130. Cyclophilin-like_PPIase_dom. IPR020892. Cyclophilin-type_PPIase_CS. [Graphical view]
Pfam	PF00160. Pro_isomerase. 1 hit. [Graphical view]
PRINTS	PR00153. CSAPPISMRASE.
SUPFAM	SSF50891. CSA_PPIase. 1 hit.
PROSITE	PS00170. CSA_PPIASE_1. 1 hit. PS50072. CSA_PPIASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPI1_BRUSU

Accession

Primary (citable) accession number: Q8G0J9
Secondary accession number(s): G0KA16

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program