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Protein

Probable peptidyl-prolyl cis-trans isomerase

Gene

ppi

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).By similarity

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: UniProtKB-KW

GO - Biological processi

  1. protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2123-MONOMER.
RETL1328306-WGS:GSTH-2124-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable peptidyl-prolyl cis-trans isomerase (EC:5.2.1.8)
Short name:
PPIase
Alternative name(s):
Rotamase
Gene namesi
Name:ppi
Ordered Locus Names:BR1094, BS1330_I1090
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I UP000000824 Componenti: Chromosome I

Subcellular locationi

Periplasm Curated

GO - Cellular componenti

  1. periplasmic space Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Chaini27 – 196170Probable peptidyl-prolyl cis-trans isomerasePRO_0000282596Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR1094.

Structurei

3D structure databases

ProteinModelPortaliQ8G0J9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 194166PPIase cyclophilin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the cyclophilin-type PPIase family.Curated
Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG0652.
HOGENOMiHOG000065981.
KOiK01802.
OMAiGNMEKGF.
OrthoDBiEOG6S26C3.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8G0J9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFIRSALAA AAFVALSIGA VQTASAADPE NTVILKLKDG DVALELRPDL
60 70 80 90 100
APKHVAQIKK LVREGAYNGV AFHRVIPGFM AQTGDVKFGN MDKGFDAARV
110 120 130 140 150
GTGGSNYPDL PAEFSKEPFV RGTVGMARSQ NPNSANSQFF IMFDDGPFLN
160 170 180 190
GQYTVVGKVV SGMDAVDKIK KGSEAENGAV KNPDKIIKAT IEADTK
Length:196
Mass (Da):20,751
Last modified:March 1, 2003 - v1
Checksum:i5577F02D377FF89B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30014.1.
CP002997 Genomic DNA. Translation: AEM18432.1.
RefSeqiNP_698099.1. NC_004310.3.
YP_005615924.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30014; AAN30014; BR1094.
AEM18432; AEM18432; BS1330_I1090.
KEGGibms:BR1094.
bsi:BS1330_I1090.
PATRICi17790522. VBIBruSui107850_1115.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30014.1.
CP002997 Genomic DNA. Translation: AEM18432.1.
RefSeqiNP_698099.1. NC_004310.3.
YP_005615924.1. NC_017251.1.

3D structure databases

ProteinModelPortaliQ8G0J9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204722.BR1094.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN30014; AAN30014; BR1094.
AEM18432; AEM18432; BS1330_I1090.
KEGGibms:BR1094.
bsi:BS1330_I1090.
PATRICi17790522. VBIBruSui107850_1115.

Phylogenomic databases

eggNOGiCOG0652.
HOGENOMiHOG000065981.
KOiK01802.
OMAiGNMEKGF.
OrthoDBiEOG6S26C3.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2123-MONOMER.
RETL1328306-WGS:GSTH-2124-MONOMER.

Family and domain databases

Gene3Di2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR020892. Cyclophilin-type_PPIase_CS.
IPR002130. Cyclophilin-type_PPIase_dom.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 1 hit.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
PIRSFiPIRSF001467. Peptidylpro_ismrse. 1 hit.
PRINTSiPR00153. CSAPPISMRASE.
SUPFAMiSSF50891. SSF50891. 1 hit.
PROSITEiPS00170. CSA_PPIASE_1. 1 hit.
PS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiPPI1_BRUSU
AccessioniPrimary (citable) accession number: Q8G0J9
Secondary accession number(s): G0KA16
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: March 1, 2003
Last modified: April 1, 2015
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.