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Q8G0I7

- LON_BRUSU

UniProt

Q8G0I7 - LON_BRUSU

Protein

Lon protease

Gene

lon

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.UniRule annotation

    Catalytic activityi

    Hydrolysis of proteins in presence of ATP.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei689 – 6891UniRule annotation
    Active sitei732 – 7321UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi367 – 3748ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. ATP-dependent peptidase activity Source: UniProtKB-HAMAP
    3. sequence-specific DNA binding Source: UniProtKB-HAMAP
    4. serine-type endopeptidase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular response to stress Source: UniProtKB-HAMAP
    2. misfolded or incompletely synthesized protein catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Stress response

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Protein family/group databases

    MEROPSiS16.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lon proteaseUniRule annotation (EC:3.4.21.53UniRule annotation)
    Alternative name(s):
    ATP-dependent protease LaUniRule annotation
    Gene namesi
    Name:lonUniRule annotation
    Ordered Locus Names:BR1106, BS1330_I1102
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 812812Lon proteasePRO_0000076124Add
    BLAST

    Proteomic databases

    PRIDEiQ8G0I7.

    Expressioni

    Inductioni

    By heat shock.UniRule annotation

    Interactioni

    Subunit structurei

    Homohexamer. Organized in a ring with a central cavity.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR1106.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G0I7.
    SMRiQ8G0I7. Positions 502-596, 604-787.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini24 – 212189LonUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S16 family.UniRule annotation
    Contains 1 Lon domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0466.
    HOGENOMiHOG000261410.
    KOiK01338.
    OMAiNATGRKY.
    OrthoDBiEOG6XHC23.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_01973. lon_bact.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR027543. Lon_bac.
    IPR004815. Lon_bac/euk-typ.
    IPR027065. Lon_Prtase.
    IPR027417. P-loop_NTPase.
    IPR008269. Pept_S16_C.
    IPR003111. Pept_S16_N.
    IPR008268. Peptidase_S16_AS.
    IPR015947. PUA-like_domain.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR10046. PTHR10046. 1 hit.
    PfamiPF00004. AAA. 1 hit.
    PF02190. LON. 1 hit.
    PF05362. Lon_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001174. Lon_proteas. 1 hit.
    SMARTiSM00382. AAA. 1 hit.
    SM00464. LON. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsiTIGR00763. lon. 1 hit.
    PROSITEiPS01046. LON_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G0I7-1 [UniParc]FASTAAdd to Basket

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    MTGIEQKTPV GGSETGGADG LYAVLPLRDI VVFPHMIVPL FVGREKSIRA    50
    LEEVMGVDKQ ILLATQKNAA DDDPAPDAIY EIGTIANVLQ LLKLPDGTVK 100
    VLVEGTARAK ISKFTDREDY HEAYAAALQE PEEDAVEIEA LARSVVSDFE 150
    NYVKLNKKIS PEVVGAASQI DDYSKLADTV ASHLAIKIPE KQEMLSVLSV 200
    RERLEKALSF MEAEISVLQV EKRIRSRVKR QMEKTQREYY LNEQMKAIQK 250
    ELGDSEDGRD EVAEIEERIT KTKLSKEARE KALAELKKLR SMSPMSAEAT 300
    VVRNYLDWLL SIPWGKKSKV KQDLNFAQEV LDAEHFGLGK VKERIVGYLA 350
    VQARSTKIKG PILCLVGPPG VGKTSLARSI AKATGREYVR MSLGGVRDEA 400
    EIRGHRRTYI GSMPGKVIQS MKKAKKSNPL FLLDEIDKMG QDFRGDPSSA 450
    MLEVLDPEQN ATFMDHYLEV EYDLSNVMFV TTANTMNIPG PLLDRMEIIR 500
    IAGYTEDEKL EIAKRHLLPK AIKDHALQPK EFSVTEDALR NVIRHYTREA 550
    GVRSLEREVM TLARKAVTEI LKTKKKSVKI TDKNLSDYLG VEKFRFGQID 600
    GEDQVGVVTG LAWTEVGGEL LTIEGVMMPG KGRMTVTGNL RDVMKESISA 650
    AASYVRSRAI DFGIEPPLFD KRDIHVHVPE GATPKDGPSA GIAMVTAIVS 700
    VLTGIPVRKD IAMTGEVTLR GRVLPIGGLK EKLLAALRGG IKKVLIPEEN 750
    AKDLAEIPDN VKNNLEIVPV SRVGEVLKHT LVRQPEPIEW TEQENPTAVP 800
    PVEDEAGASL AH 812
    Length:812
    Mass (Da):89,795
    Last modified:March 1, 2003 - v1
    Checksum:i0F0AC318C9227FBF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30026.1.
    CP002997 Genomic DNA. Translation: AEM18444.1.
    RefSeqiNP_698111.1. NC_004310.3.
    YP_005615936.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30026; AAN30026; BR1106.
    AEM18444; AEM18444; BS1330_I1102.
    GeneIDi1166782.
    12138135.
    KEGGibms:BR1106.
    bsi:BS1330_I1102.
    PATRICi17790546. VBIBruSui107850_1127.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30026.1 .
    CP002997 Genomic DNA. Translation: AEM18444.1 .
    RefSeqi NP_698111.1. NC_004310.3.
    YP_005615936.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G0I7.
    SMRi Q8G0I7. Positions 502-596, 604-787.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1106.

    Protein family/group databases

    MEROPSi S16.001.

    Proteomic databases

    PRIDEi Q8G0I7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30026 ; AAN30026 ; BR1106 .
    AEM18444 ; AEM18444 ; BS1330_I1102 .
    GeneIDi 1166782.
    12138135.
    KEGGi bms:BR1106.
    bsi:BS1330_I1102.
    PATRICi 17790546. VBIBruSui107850_1127.

    Phylogenomic databases

    eggNOGi COG0466.
    HOGENOMi HOG000261410.
    KOi K01338.
    OMAi NATGRKY.
    OrthoDBi EOG6XHC23.

    Miscellaneous databases

    PROi Q8G0I7.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_01973. lon_bact.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR027543. Lon_bac.
    IPR004815. Lon_bac/euk-typ.
    IPR027065. Lon_Prtase.
    IPR027417. P-loop_NTPase.
    IPR008269. Pept_S16_C.
    IPR003111. Pept_S16_N.
    IPR008268. Peptidase_S16_AS.
    IPR015947. PUA-like_domain.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR10046. PTHR10046. 1 hit.
    Pfami PF00004. AAA. 1 hit.
    PF02190. LON. 1 hit.
    PF05362. Lon_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001174. Lon_proteas. 1 hit.
    SMARTi SM00382. AAA. 1 hit.
    SM00464. LON. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF88697. SSF88697. 1 hit.
    TIGRFAMsi TIGR00763. lon. 1 hit.
    PROSITEi PS01046. LON_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiLON_BRUSU
    AccessioniPrimary (citable) accession number: Q8G0I7
    Secondary accession number(s): G0KA28
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 7, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3