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Q8G0I5 (CLPX_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP-dependent Clp protease ATP-binding subunit ClpX
Gene names
Name:clpX
Ordered Locus Names:BR1108, BS1330_I1104
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP By similarity. HAMAP-Rule MF_00175

Subunit structure

Heterodimer of ClpP and ClpX By similarity. HAMAP-Rule MF_00175

Sequence similarities

Belongs to the ClpX chaperone family.

Ontologies

Keywords
   DomainZinc-finger
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionChaperone
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processprotein folding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleoside-triphosphatase activity

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424ATP-dependent Clp protease ATP-binding subunit ClpX HAMAP-Rule MF_00175
PRO_0000160327

Regions

Zinc finger17 – 4226C4-type HAMAP-Rule MF_00175
Nucleotide binding120 – 1278ATP Potential

Sequences

Sequence LengthMass (Da)Tools
Q8G0I5 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 7F88089A2D3A9612

FASTA42446,636
        10         20         30         40         50         60 
MSKVSNGGGD SKNTLYCSFC GKSQHEVRKL IAGPTVFICD ECVELCMDII REENKSSMVK 

        70         80         90        100        110        120 
SREGVPTPQE IMAVLDDYVI GQKDAKRVLS VAVHNHYKRL AHQSKNSDIE LAKSNILLVG 

       130        140        150        160        170        180 
PTGCGKTYLA QTLARIIDVP FIMADATTLT EAGYVGEDVE NIILKLLQAA DYNVERAQRG 

       190        200        210        220        230        240 
IVYIDEVDKI SRKSDNPSIT RDVSGEGVQQ ALLKIMEGTV ASVPPQGGRK HPQQEFLQVD 

       250        260        270        280        290        300 
TTNILFICGG AFAGLDRIIS ARGEKTSIGF GATVKSVDER RIGEVFKELE PEDLLKFGLI 

       310        320        330        340        350        360 
PEFVGRLPVI ATLEDLDVDA LVQILTEPKN ALVKQYQRLF DMENVELVFH DDALRAIANK 

       370        380        390        400        410        420 
AVEHKTGARG LRSIMEKILL DTMFELPTLE GVREVVISGD VVDGSARPLY IYAERQDEKG 


NVSA 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN30028.1.
CP002997 Genomic DNA. Translation: AEM18446.1.
RefSeqNP_698113.1. NC_004310.3.
YP_005615938.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G0I5.
SMRQ8G0I5. Positions 11-53.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR1108.

Proteomic databases

PRIDEQ8G0I5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30028; AAN30028; BR1108.
AEM18446; AEM18446; BS1330_I1104.
GeneID1166784.
12138137.
KEGGbms:BR1108.
bsi:BS1330_I1104.
PATRIC17790548. VBIBruSui107850_1128.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1219.
HOGENOMHOG000010093.
KOK03544.
OMALDTMFDL.
OrthoDBEOG625JZK.
ProtClustDBPRK05342.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_00175. ClpX.
InterProIPR003593. AAA+_ATPase.
IPR013093. ATPase_AAA-2.
IPR019489. Clp_ATPase_C.
IPR004487. Clp_protease_ATP-bd_su_ClpX.
IPR027417. P-loop_NTPase.
IPR010603. Znf_CppX_C4.
[Graphical view]
PfamPF07724. AAA_2. 1 hit.
PF10431. ClpB_D2-small. 1 hit.
PF06689. zf-C4_ClpX. 1 hit.
[Graphical view]
SMARTSM00382. AAA. 1 hit.
SM01086. ClpB_D2-small. 1 hit.
SM00994. zf-C4_ClpX. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00382. clpX. 1 hit.
ProtoNetSearch...

Entry information

Entry nameCLPX_BRUSU
AccessionPrimary (citable) accession number: Q8G0I5
Secondary accession number(s): G0KA30
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names