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Q8G0I5

- CLPX_BRUSU

UniProt

Q8G0I5 - CLPX_BRUSU

Protein

ATP-dependent Clp protease ATP-binding subunit ClpX

Gene

clpX

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri17 – 4226C4-typeUniRule annotationAdd
    BLAST
    Nucleotide bindingi121 – 1288ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. nucleoside-triphosphatase activity Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. protein folding Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Chaperone

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent Clp protease ATP-binding subunit ClpXUniRule annotation
    Gene namesi
    Name:clpXUniRule annotation
    Ordered Locus Names:BR1108, BS1330_I1104
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424ATP-dependent Clp protease ATP-binding subunit ClpXPRO_0000160327Add
    BLAST

    Proteomic databases

    PRIDEiQ8G0I5.

    Interactioni

    Subunit structurei

    Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR1108.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G0I5.
    SMRiQ8G0I5. Positions 11-53.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ClpX chaperone family.UniRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri17 – 4226C4-typeUniRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiCOG1219.
    HOGENOMiHOG000010093.
    KOiK03544.
    OMAiILLDIMY.
    OrthoDBiEOG625JZK.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_00175. ClpX.
    InterProiIPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view]
    PfamiPF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SMARTiSM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00382. clpX. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8G0I5-1 [UniParc]FASTAAdd to Basket

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    MSKVSNGGGD SKNTLYCSFC GKSQHEVRKL IAGPTVFICD ECVELCMDII    50
    REENKSSMVK SREGVPTPQE IMAVLDDYVI GQKDAKRVLS VAVHNHYKRL 100
    AHQSKNSDIE LAKSNILLVG PTGCGKTYLA QTLARIIDVP FIMADATTLT 150
    EAGYVGEDVE NIILKLLQAA DYNVERAQRG IVYIDEVDKI SRKSDNPSIT 200
    RDVSGEGVQQ ALLKIMEGTV ASVPPQGGRK HPQQEFLQVD TTNILFICGG 250
    AFAGLDRIIS ARGEKTSIGF GATVKSVDER RIGEVFKELE PEDLLKFGLI 300
    PEFVGRLPVI ATLEDLDVDA LVQILTEPKN ALVKQYQRLF DMENVELVFH 350
    DDALRAIANK AVEHKTGARG LRSIMEKILL DTMFELPTLE GVREVVISGD 400
    VVDGSARPLY IYAERQDEKG NVSA 424
    Length:424
    Mass (Da):46,636
    Last modified:March 1, 2003 - v1
    Checksum:i7F88089A2D3A9612
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30028.1.
    CP002997 Genomic DNA. Translation: AEM18446.1.
    RefSeqiNP_698113.1. NC_004310.3.
    YP_005615938.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30028; AAN30028; BR1108.
    AEM18446; AEM18446; BS1330_I1104.
    GeneIDi1166784.
    12138137.
    KEGGibms:BR1108.
    bsi:BS1330_I1104.
    PATRICi17790548. VBIBruSui107850_1128.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30028.1 .
    CP002997 Genomic DNA. Translation: AEM18446.1 .
    RefSeqi NP_698113.1. NC_004310.3.
    YP_005615938.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G0I5.
    SMRi Q8G0I5. Positions 11-53.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1108.

    Proteomic databases

    PRIDEi Q8G0I5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30028 ; AAN30028 ; BR1108 .
    AEM18446 ; AEM18446 ; BS1330_I1104 .
    GeneIDi 1166784.
    12138137.
    KEGGi bms:BR1108.
    bsi:BS1330_I1104.
    PATRICi 17790548. VBIBruSui107850_1128.

    Phylogenomic databases

    eggNOGi COG1219.
    HOGENOMi HOG000010093.
    KOi K03544.
    OMAi ILLDIMY.
    OrthoDBi EOG625JZK.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_00175. ClpX.
    InterProi IPR003593. AAA+_ATPase.
    IPR003959. ATPase_AAA_core.
    IPR019489. Clp_ATPase_C.
    IPR004487. Clp_protease_ATP-bd_su_ClpX.
    IPR027417. P-loop_NTPase.
    IPR010603. Znf_CppX_C4.
    [Graphical view ]
    Pfami PF07724. AAA_2. 1 hit.
    PF10431. ClpB_D2-small. 1 hit.
    PF06689. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SMARTi SM00382. AAA. 1 hit.
    SM01086. ClpB_D2-small. 1 hit.
    SM00994. zf-C4_ClpX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00382. clpX. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiCLPX_BRUSU
    AccessioniPrimary (citable) accession number: Q8G0I5
    Secondary accession number(s): G0KA30
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3