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Q8G0E4

- FABZ_BRUSU

UniProt

Q8G0E4 - FABZ_BRUSU

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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei58 – 581UniRule annotation

GO - Molecular functioni

  1. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
  2. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
Short name:
(3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
Gene namesi
Name:fabZUniRule annotation
Ordered Locus Names:BR1152, BS1330_I1148
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1571573-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZPRO_0000091652Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR1152.

Structurei

3D structure databases

ProteinModelPortaliQ8G0E4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0764.
HOGENOMiHOG000277829.
KOiK02372.
OMAiTIEYHMR.
OrthoDBiEOG6JTCGM.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G0E4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDDNQTKLE AADIQALLAV LPHRYPFLLI DRIVDIDGDV SATGIKNVTI
60 70 80 90 100
NEPHFTGHFP ENPIMPGVLI VEAMAQTAGA ISLLQRKTGR PGVVYFMTID
110 120 130 140 150
NAKFRRPVVP GDRLLLHVKK IKQRANISKY ECVAEVDGVK VAEAEVAAMI

SVADENL
Length:157
Mass (Da):17,188
Last modified:March 1, 2003 - v1
Checksum:i473C693E16126103
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30072.1.
CP002997 Genomic DNA. Translation: AEM18490.1.
RefSeqiNP_698157.1. NC_004310.3.
YP_005615982.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30072; AAN30072; BR1152.
AEM18490; AEM18490; BS1330_I1148.
GeneIDi1166828.
12138181.
KEGGibms:BR1152.
bsi:BS1330_I1148.
PATRICi17790637. VBIBruSui107850_1172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30072.1 .
CP002997 Genomic DNA. Translation: AEM18490.1 .
RefSeqi NP_698157.1. NC_004310.3.
YP_005615982.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G0E4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR1152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN30072 ; AAN30072 ; BR1152 .
AEM18490 ; AEM18490 ; BS1330_I1148 .
GeneIDi 1166828.
12138181.
KEGGi bms:BR1152.
bsi:BS1330_I1148.
PATRICi 17790637. VBIBruSui107850_1172.

Phylogenomic databases

eggNOGi COG0764.
HOGENOMi HOG000277829.
KOi K02372.
OMAi TIEYHMR.
OrthoDBi EOG6JTCGM.

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
HAMAPi MF_00406. FabZ.
InterProi IPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view ]
Pfami PF07977. FabA. 1 hit.
[Graphical view ]
SUPFAMi SSF54637. SSF54637. 1 hit.
TIGRFAMsi TIGR01750. fabZ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiFABZ_BRUSU
AccessioniPrimary (citable) accession number: Q8G0E4
Secondary accession number(s): G0KA74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3