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Q8G0E4

- FABZ_BRUSU

UniProt

Q8G0E4 - FABZ_BRUSU

Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene

fabZ

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 69 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs.UniRule annotation

    Catalytic activityi

    A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei58 – 581UniRule annotation

    GO - Molecular functioni

    1. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
    2. lipid A biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Lyase

    Keywords - Biological processi

    Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotation (EC:4.2.1.59UniRule annotation)
    Alternative name(s):
    (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydrataseUniRule annotation
    Short name:
    (3R)-hydroxymyristoyl-ACP dehydraseUniRule annotation
    Beta-hydroxyacyl-ACP dehydrataseUniRule annotation
    Gene namesi
    Name:fabZUniRule annotation
    Ordered Locus Names:BR1152, BS1330_I1148
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 1571573-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZPRO_0000091652Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BR1152.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G0E4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the thioester dehydratase family. FabZ subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0764.
    HOGENOMiHOG000277829.
    KOiK02372.
    OMAiTIEYHMR.
    OrthoDBiEOG6JTCGM.

    Family and domain databases

    Gene3Di3.10.129.10. 1 hit.
    HAMAPiMF_00406. FabZ.
    InterProiIPR013114. FabA_FabZ.
    IPR010084. FabZ.
    IPR029069. HotDog_dom.
    [Graphical view]
    PfamiPF07977. FabA. 1 hit.
    [Graphical view]
    SUPFAMiSSF54637. SSF54637. 1 hit.
    TIGRFAMsiTIGR01750. fabZ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8G0E4-1 [UniParc]FASTAAdd to Basket

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    MSDDNQTKLE AADIQALLAV LPHRYPFLLI DRIVDIDGDV SATGIKNVTI    50
    NEPHFTGHFP ENPIMPGVLI VEAMAQTAGA ISLLQRKTGR PGVVYFMTID 100
    NAKFRRPVVP GDRLLLHVKK IKQRANISKY ECVAEVDGVK VAEAEVAAMI 150
    SVADENL 157
    Length:157
    Mass (Da):17,188
    Last modified:March 1, 2003 - v1
    Checksum:i473C693E16126103
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30072.1.
    CP002997 Genomic DNA. Translation: AEM18490.1.
    RefSeqiNP_698157.1. NC_004310.3.
    YP_005615982.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30072; AAN30072; BR1152.
    AEM18490; AEM18490; BS1330_I1148.
    GeneIDi1166828.
    12138181.
    KEGGibms:BR1152.
    bsi:BS1330_I1148.
    PATRICi17790637. VBIBruSui107850_1172.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30072.1 .
    CP002997 Genomic DNA. Translation: AEM18490.1 .
    RefSeqi NP_698157.1. NC_004310.3.
    YP_005615982.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G0E4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1152.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30072 ; AAN30072 ; BR1152 .
    AEM18490 ; AEM18490 ; BS1330_I1148 .
    GeneIDi 1166828.
    12138181.
    KEGGi bms:BR1152.
    bsi:BS1330_I1148.
    PATRICi 17790637. VBIBruSui107850_1172.

    Phylogenomic databases

    eggNOGi COG0764.
    HOGENOMi HOG000277829.
    KOi K02372.
    OMAi TIEYHMR.
    OrthoDBi EOG6JTCGM.

    Family and domain databases

    Gene3Di 3.10.129.10. 1 hit.
    HAMAPi MF_00406. FabZ.
    InterProi IPR013114. FabA_FabZ.
    IPR010084. FabZ.
    IPR029069. HotDog_dom.
    [Graphical view ]
    Pfami PF07977. FabA. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54637. SSF54637. 1 hit.
    TIGRFAMsi TIGR01750. fabZ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiFABZ_BRUSU
    AccessioniPrimary (citable) accession number: Q8G0E4
    Secondary accession number(s): G0KA74
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 4, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 69 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3