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Q8G0E4

- FABZ_BRUSU

UniProt

Q8G0E4 - FABZ_BRUSU

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Protein

3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ

Gene
fabZ, BR1152, BS1330_I1148
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs By similarity.UniRule annotation

Catalytic activityi

A (3R)-3-hydroxyacyl-[acyl-carrier protein] = a trans-2-enoyl-[acyl-carrier protein] + H2O.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei58 – 581 By similarity

GO - Molecular functioni

  1. 3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
  2. lipid A biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (EC:4.2.1.59)
Alternative name(s):
(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase
Short name:
(3R)-hydroxymyristoyl-ACP dehydrase
Beta-hydroxyacyl-ACP dehydratase
Gene namesi
Name:fabZ
Ordered Locus Names:BR1152, BS1330_I1148
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 1571573-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZUniRule annotationPRO_0000091652Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR1152.

Structurei

3D structure databases

ProteinModelPortaliQ8G0E4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0764.
HOGENOMiHOG000277829.
KOiK02372.
OMAiTIEYHMR.
OrthoDBiEOG6JTCGM.

Family and domain databases

Gene3Di3.10.129.10. 1 hit.
HAMAPiMF_00406. FabZ.
InterProiIPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view]
PfamiPF07977. FabA. 1 hit.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 1 hit.
TIGRFAMsiTIGR01750. fabZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8G0E4-1 [UniParc]FASTAAdd to Basket

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MSDDNQTKLE AADIQALLAV LPHRYPFLLI DRIVDIDGDV SATGIKNVTI    50
NEPHFTGHFP ENPIMPGVLI VEAMAQTAGA ISLLQRKTGR PGVVYFMTID 100
NAKFRRPVVP GDRLLLHVKK IKQRANISKY ECVAEVDGVK VAEAEVAAMI 150
SVADENL 157
Length:157
Mass (Da):17,188
Last modified:March 1, 2003 - v1
Checksum:i473C693E16126103
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30072.1.
CP002997 Genomic DNA. Translation: AEM18490.1.
RefSeqiNP_698157.1. NC_004310.3.
YP_005615982.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30072; AAN30072; BR1152.
AEM18490; AEM18490; BS1330_I1148.
GeneIDi1166828.
12138181.
KEGGibms:BR1152.
bsi:BS1330_I1148.
PATRICi17790637. VBIBruSui107850_1172.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30072.1 .
CP002997 Genomic DNA. Translation: AEM18490.1 .
RefSeqi NP_698157.1. NC_004310.3.
YP_005615982.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G0E4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR1152.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN30072 ; AAN30072 ; BR1152 .
AEM18490 ; AEM18490 ; BS1330_I1148 .
GeneIDi 1166828.
12138181.
KEGGi bms:BR1152.
bsi:BS1330_I1148.
PATRICi 17790637. VBIBruSui107850_1172.

Phylogenomic databases

eggNOGi COG0764.
HOGENOMi HOG000277829.
KOi K02372.
OMAi TIEYHMR.
OrthoDBi EOG6JTCGM.

Family and domain databases

Gene3Di 3.10.129.10. 1 hit.
HAMAPi MF_00406. FabZ.
InterProi IPR013114. FabA_FabZ.
IPR010084. FabZ.
IPR029069. HotDog_dom.
[Graphical view ]
Pfami PF07977. FabA. 1 hit.
[Graphical view ]
SUPFAMi SSF54637. SSF54637. 1 hit.
TIGRFAMsi TIGR01750. fabZ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiFABZ_BRUSU
AccessioniPrimary (citable) accession number: Q8G0E4
Secondary accession number(s): G0KA74
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 4, 2003
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi