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Protein

Phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
Ordered Locus Names:BR1157, BS1330_I1153
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I UP000000824 Componenti: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei19 – 3921HelicalSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 12121HelicalSequence AnalysisAdd
BLAST
Transmembranei126 – 14621HelicalSequence AnalysisAdd
BLAST
Transmembranei183 – 20321HelicalSequence AnalysisAdd
BLAST
Transmembranei248 – 26821HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 270270Phosphatidate cytidylyltransferasePRO_0000090730Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi204722.BR1157.

Family & Domainsi

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000006169.
KOiK00981.
OMAiGFILYEW.
OrthoDBiEOG6TBHJT.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G0E0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNLQTRIIT AIVLGTITLW LTWVGGVGFT LFSIAIGLAM FYEWTELSAT
60 70 80 90 100
RQTAFSRLFG WAWLIVTGIL LILDRGALLT IGFLVAGCAI LLVTQWKSGR
110 120 130 140 150
GWPAAGLFYA GFSALSLSLL RGDEPFGFTT IVFLFAVVWS TDIAAYFNGR
160 170 180 190 200
ALGGPKLAPR FSPNKTWSGA IGGAAAAVAG GLLVASLVAA PGGWGVPVLA
210 220 230 240 250
LLLSIVSQIG DLAESWVKRQ FGAKDSGRLL PGHGGVLDRV DGLVAAAALL
260 270
YLFGAIFAEP DVPSAIFFSF
Length:270
Mass (Da):28,402
Last modified:February 28, 2003 - v1
Checksum:i378253042865F666
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30077.1.
CP002997 Genomic DNA. Translation: AEM18495.1.
RefSeqiNP_698162.1. NC_004310.3.
YP_005615987.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30077; AAN30077; BR1157.
AEM18495; AEM18495; BS1330_I1153.
KEGGibms:BR1157.
bsi:BS1330_I1153.
PATRICi17790645. VBIBruSui107850_1176.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30077.1.
CP002997 Genomic DNA. Translation: AEM18495.1.
RefSeqiNP_698162.1. NC_004310.3.
YP_005615987.1. NC_017251.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi204722.BR1157.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN30077; AAN30077; BR1157.
AEM18495; AEM18495; BS1330_I1153.
KEGGibms:BR1157.
bsi:BS1330_I1153.
PATRICi17790645. VBIBruSui107850_1176.

Phylogenomic databases

eggNOGiCOG0575.
HOGENOMiHOG000006169.
KOiK00981.
OMAiGFILYEW.
OrthoDBiEOG6TBHJT.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.

Family and domain databases

InterProiIPR000374. PC_trans.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PROSITEiPS01315. CDS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiCDSA_BRUSU
AccessioniPrimary (citable) accession number: Q8G0E0
Secondary accession number(s): G0KA79
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 6, 2003
Last sequence update: February 28, 2003
Last modified: March 31, 2015
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.