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Q8G0D9

- ISPT_BRUSU

UniProt

Q8G0D9 - ISPT_BRUSU

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Protein

Isoprenyl transferase

Gene

uppS

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei12 – 121UniRule annotation
Metal bindingi12 – 121MagnesiumUniRule annotation
Binding sitei17 – 171SubstrateUniRule annotation
Binding sitei25 – 251SubstrateUniRule annotation
Binding sitei29 – 291SubstrateUniRule annotation
Active sitei60 – 601Proton acceptorUniRule annotation
Binding sitei61 – 611SubstrateUniRule annotation
Binding sitei63 – 631SubstrateUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation
Metal bindingi199 – 1991MagnesiumUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. prenyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:BR1158, BS1330_I1154
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Isoprenyl transferasePRO_0000123583Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR1158.

Structurei

3D structure databases

ProteinModelPortaliQ8G0D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 164Substrate bindingUniRule annotation
Regioni57 – 593Substrate bindingUniRule annotation
Regioni186 – 1883Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000006056.
KOiK00806.
OMAiNRPEQEV.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G0D9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDPRHIAII MDGNGRWAKA RGLPRSAGHR AGVEALREIV RAAGDRGLGY
60 70 80 90 100
LTLFAFSSEN WTRPSGEVSD LLGLLKLFIR RDLAELHRNN VRVNIIGERA
110 120 130 140 150
ELAADIRALL NEAESLTHRN TGLNLVIAFN YGSRDEIVRA VRSLARDVAA
160 170 180 190 200
GLLDPSSISA ELVSANLDTA GIPDPDLIIR TSGEMRLSNF LLWQAAYSEF
210 220 230 240 250
LFLPCHWPDF RPTDLDAAYE TFRQRERRFG GVEPRASADA EEEILCPSTK

GAAV
Length:254
Mass (Da):28,036
Last modified:March 1, 2003 - v1
Checksum:i7FB3772A6719A9CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30078.1.
CP002997 Genomic DNA. Translation: AEM18496.1.
RefSeqiNP_698163.1. NC_004310.3.
YP_005615988.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30078; AAN30078; BR1158.
AEM18496; AEM18496; BS1330_I1154.
GeneIDi1166834.
12138187.
KEGGibms:BR1158.
bsi:BS1330_I1154.
PATRICi17790647. VBIBruSui107850_1177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30078.1 .
CP002997 Genomic DNA. Translation: AEM18496.1 .
RefSeqi NP_698163.1. NC_004310.3.
YP_005615988.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G0D9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR1158.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN30078 ; AAN30078 ; BR1158 .
AEM18496 ; AEM18496 ; BS1330_I1154 .
GeneIDi 1166834.
12138187.
KEGGi bms:BR1158.
bsi:BS1330_I1154.
PATRICi 17790647. VBIBruSui107850_1177.

Phylogenomic databases

eggNOGi COG0020.
HOGENOMi HOG000006056.
KOi K00806.
OMAi NRPEQEV.
OrthoDBi EOG68H89T.

Miscellaneous databases

PROi Q8G0D9.

Family and domain databases

Gene3Di 3.40.1180.10. 1 hit.
HAMAPi MF_01139. ISPT.
InterProi IPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view ]
PANTHERi PTHR10291. PTHR10291. 1 hit.
Pfami PF01255. Prenyltransf. 1 hit.
[Graphical view ]
SUPFAMi SSF64005. SSF64005. 1 hit.
TIGRFAMsi TIGR00055. uppS. 1 hit.
PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiISPT_BRUSU
AccessioniPrimary (citable) accession number: Q8G0D9
Secondary accession number(s): G0KA80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2003
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3