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Q8G0D9

- ISPT_BRUSU

UniProt

Q8G0D9 - ISPT_BRUSU

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Protein
Isoprenyl transferase
Gene
uppS, BR1158, BS1330_I1154
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids By similarity.UniRule annotation

Cofactori

Binds 2 magnesium ions per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei12 – 121 By similarity
Metal bindingi12 – 121Magnesium By similarity
Binding sitei17 – 171Substrate By similarity
Binding sitei25 – 251Substrate By similarity
Binding sitei29 – 291Substrate By similarity
Active sitei60 – 601Proton acceptor By similarity
Binding sitei61 – 611Substrate By similarity
Binding sitei63 – 631Substrate By similarity
Binding sitei180 – 1801Substrate By similarity
Metal bindingi199 – 1991Magnesium By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. prenyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

    Complete GO annotation...

    Keywords - Molecular functioni

    Transferase

    Keywords - Ligandi

    Magnesium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Isoprenyl transferase (EC:2.5.1.-)
    Gene namesi
    Name:uppS
    Ordered Locus Names:BR1158, BS1330_I1154
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 254254Isoprenyl transferaseUniRule annotation
    PRO_0000123583Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer By similarity.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR1158.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G0D9.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni13 – 164Substrate binding By similarity
    Regioni57 – 593Substrate binding By similarity
    Regioni186 – 1883Substrate binding By similarity

    Sequence similaritiesi

    Belongs to the UPP synthase family.

    Phylogenomic databases

    eggNOGiCOG0020.
    HOGENOMiHOG000006056.
    KOiK00806.
    OMAiNRPEQEV.
    OrthoDBiEOG68H89T.

    Family and domain databases

    Gene3Di3.40.1180.10. 1 hit.
    HAMAPiMF_01139. ISPT.
    InterProiIPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view]
    PANTHERiPTHR10291. PTHR10291. 1 hit.
    PfamiPF01255. Prenyltransf. 1 hit.
    [Graphical view]
    SUPFAMiSSF64005. SSF64005. 1 hit.
    TIGRFAMsiTIGR00055. uppS. 1 hit.
    PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G0D9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDPRHIAII MDGNGRWAKA RGLPRSAGHR AGVEALREIV RAAGDRGLGY    50
    LTLFAFSSEN WTRPSGEVSD LLGLLKLFIR RDLAELHRNN VRVNIIGERA 100
    ELAADIRALL NEAESLTHRN TGLNLVIAFN YGSRDEIVRA VRSLARDVAA 150
    GLLDPSSISA ELVSANLDTA GIPDPDLIIR TSGEMRLSNF LLWQAAYSEF 200
    LFLPCHWPDF RPTDLDAAYE TFRQRERRFG GVEPRASADA EEEILCPSTK 250
    GAAV 254
    Length:254
    Mass (Da):28,036
    Last modified:March 1, 2003 - v1
    Checksum:i7FB3772A6719A9CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30078.1.
    CP002997 Genomic DNA. Translation: AEM18496.1.
    RefSeqiNP_698163.1. NC_004310.3.
    YP_005615988.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30078; AAN30078; BR1158.
    AEM18496; AEM18496; BS1330_I1154.
    GeneIDi1166834.
    12138187.
    KEGGibms:BR1158.
    bsi:BS1330_I1154.
    PATRICi17790647. VBIBruSui107850_1177.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30078.1 .
    CP002997 Genomic DNA. Translation: AEM18496.1 .
    RefSeqi NP_698163.1. NC_004310.3.
    YP_005615988.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G0D9.
    ModBasei Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1158.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30078 ; AAN30078 ; BR1158 .
    AEM18496 ; AEM18496 ; BS1330_I1154 .
    GeneIDi 1166834.
    12138187.
    KEGGi bms:BR1158.
    bsi:BS1330_I1154.
    PATRICi 17790647. VBIBruSui107850_1177.

    Phylogenomic databases

    eggNOGi COG0020.
    HOGENOMi HOG000006056.
    KOi K00806.
    OMAi NRPEQEV.
    OrthoDBi EOG68H89T.

    Miscellaneous databases

    PROi Q8G0D9.

    Family and domain databases

    Gene3Di 3.40.1180.10. 1 hit.
    HAMAPi MF_01139. ISPT.
    InterProi IPR001441. UPP_synth-like.
    IPR018520. UPP_synth-like_CS.
    [Graphical view ]
    PANTHERi PTHR10291. PTHR10291. 1 hit.
    Pfami PF01255. Prenyltransf. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64005. SSF64005. 1 hit.
    TIGRFAMsi TIGR00055. uppS. 1 hit.
    PROSITEi PS01066. UPP_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiISPT_BRUSU
    AccessioniPrimary (citable) accession number: Q8G0D9
    Secondary accession number(s): G0KA80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 16, 2004
    Last sequence update: March 1, 2003
    Last modified: May 14, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3

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