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Q8G0D9 (ISPT_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Isoprenyl transferase

EC=2.5.1.-
Gene names
Name:uppS
Ordered Locus Names:BR1158, BS1330_I1154
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length254 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids By similarity. HAMAP-Rule MF_01139

Cofactor

Binds 2 magnesium ions per subunit By similarity. HAMAP-Rule MF_01139

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01139

Sequence similarities

Belongs to the UPP synthase family.

Ontologies

Keywords
   LigandMagnesium
Metal-binding
   Molecular functionTransferase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular_functionmagnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

prenyltransferase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 254254Isoprenyl transferase HAMAP-Rule MF_01139
PRO_0000123583

Regions

Region13 – 164Substrate binding By similarity
Region57 – 593Substrate binding By similarity
Region186 – 1883Substrate binding By similarity

Sites

Active site121 By similarity
Active site601Proton acceptor By similarity
Metal binding121Magnesium By similarity
Metal binding1991Magnesium By similarity
Binding site171Substrate By similarity
Binding site251Substrate By similarity
Binding site291Substrate By similarity
Binding site611Substrate By similarity
Binding site631Substrate By similarity
Binding site1801Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G0D9 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 7FB3772A6719A9CC

FASTA25428,036
        10         20         30         40         50         60 
MSDPRHIAII MDGNGRWAKA RGLPRSAGHR AGVEALREIV RAAGDRGLGY LTLFAFSSEN 

        70         80         90        100        110        120 
WTRPSGEVSD LLGLLKLFIR RDLAELHRNN VRVNIIGERA ELAADIRALL NEAESLTHRN 

       130        140        150        160        170        180 
TGLNLVIAFN YGSRDEIVRA VRSLARDVAA GLLDPSSISA ELVSANLDTA GIPDPDLIIR 

       190        200        210        220        230        240 
TSGEMRLSNF LLWQAAYSEF LFLPCHWPDF RPTDLDAAYE TFRQRERRFG GVEPRASADA 

       250 
EEEILCPSTK GAAV 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN30078.1.
CP002997 Genomic DNA. Translation: AEM18496.1.
RefSeqNP_698163.1. NC_004310.3.
YP_005615988.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G0D9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR1158.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30078; AAN30078; BR1158.
AEM18496; AEM18496; BS1330_I1154.
GeneID1166834.
12138187.
KEGGbms:BR1158.
bsi:BS1330_I1154.
PATRIC17790647. VBIBruSui107850_1177.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0020.
HOGENOMHOG000006056.
KOK00806.
OMANRPEQEV.
OrthoDBEOG68H89T.

Family and domain databases

Gene3D3.40.1180.10. 1 hit.
HAMAPMF_01139. ISPT.
InterProIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERPTHR10291. PTHR10291. 1 hit.
PfamPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMSSF64005. SSF64005. 1 hit.
TIGRFAMsTIGR00055. uppS. 1 hit.
PROSITEPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8G0D9.

Entry information

Entry nameISPT_BRUSU
AccessionPrimary (citable) accession number: Q8G0D9
Secondary accession number(s): G0KA80
Entry history
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names