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Protein

Isoprenyl transferase

Gene

uppS

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei12 – 121UniRule annotation
Metal bindingi12 – 121MagnesiumUniRule annotation
Binding sitei17 – 171SubstrateUniRule annotation
Binding sitei25 – 251SubstrateUniRule annotation
Binding sitei29 – 291SubstrateUniRule annotation
Active sitei60 – 601Proton acceptorUniRule annotation
Binding sitei61 – 611SubstrateUniRule annotation
Binding sitei63 – 631SubstrateUniRule annotation
Binding sitei180 – 1801SubstrateUniRule annotation
Metal bindingi199 – 1991MagnesiumUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Isoprenyl transferaseUniRule annotation (EC:2.5.1.-UniRule annotation)
Gene namesi
Name:uppSUniRule annotation
Ordered Locus Names:BR1158, BS1330_I1154
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 254254Isoprenyl transferasePRO_0000123583Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8G0D9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni13 – 164Substrate bindingUniRule annotation
Regioni57 – 593Substrate bindingUniRule annotation
Regioni186 – 1883Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the UPP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000006056.
KOiK00806.
OMAiYQNRERR.
OrthoDBiEOG68H89T.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G0D9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDPRHIAII MDGNGRWAKA RGLPRSAGHR AGVEALREIV RAAGDRGLGY
60 70 80 90 100
LTLFAFSSEN WTRPSGEVSD LLGLLKLFIR RDLAELHRNN VRVNIIGERA
110 120 130 140 150
ELAADIRALL NEAESLTHRN TGLNLVIAFN YGSRDEIVRA VRSLARDVAA
160 170 180 190 200
GLLDPSSISA ELVSANLDTA GIPDPDLIIR TSGEMRLSNF LLWQAAYSEF
210 220 230 240 250
LFLPCHWPDF RPTDLDAAYE TFRQRERRFG GVEPRASADA EEEILCPSTK

GAAV
Length:254
Mass (Da):28,036
Last modified:March 1, 2003 - v1
Checksum:i7FB3772A6719A9CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30078.1.
CP002997 Genomic DNA. Translation: AEM18496.1.
RefSeqiWP_004690895.1. NZ_KN046804.1.

Genome annotation databases

EnsemblBacteriaiAAN30078; AAN30078; BR1158.
AEM18496; AEM18496; BS1330_I1154.
KEGGibms:BR1158.
bsi:BS1330_I1154.
PATRICi17790647. VBIBruSui107850_1177.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30078.1.
CP002997 Genomic DNA. Translation: AEM18496.1.
RefSeqiWP_004690895.1. NZ_KN046804.1.

3D structure databases

ProteinModelPortaliQ8G0D9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN30078; AAN30078; BR1158.
AEM18496; AEM18496; BS1330_I1154.
KEGGibms:BR1158.
bsi:BS1330_I1154.
PATRICi17790647. VBIBruSui107850_1177.

Phylogenomic databases

eggNOGiCOG0020.
HOGENOMiHOG000006056.
KOiK00806.
OMAiYQNRERR.
OrthoDBiEOG68H89T.

Miscellaneous databases

PROiQ8G0D9.

Family and domain databases

Gene3Di3.40.1180.10. 1 hit.
HAMAPiMF_01139. ISPT.
InterProiIPR001441. UPP_synth-like.
IPR018520. UPP_synth-like_CS.
[Graphical view]
PANTHERiPTHR10291. PTHR10291. 1 hit.
PfamiPF01255. Prenyltransf. 1 hit.
[Graphical view]
SUPFAMiSSF64005. SSF64005. 1 hit.
TIGRFAMsiTIGR00055. uppS. 1 hit.
PROSITEiPS01066. UPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiISPT_BRUSU
AccessioniPrimary (citable) accession number: Q8G0D9
Secondary accession number(s): G0KA80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 16, 2004
Last sequence update: March 1, 2003
Last modified: July 22, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.