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Q8G080

- RL22_BRUSU

UniProt

Q8G080 - RL22_BRUSU

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Protein
50S ribosomal protein L22
Gene
rplV, BR1228, BS1330_I1224
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome By similarity.UniRule annotation
The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome By similarity.UniRule annotation

GO - Molecular functioni

  1. rRNA binding Source: UniProtKB-HAMAP
  2. structural constituent of ribosome Source: InterPro

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Keywords - Ligandi

RNA-binding, rRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
50S ribosomal protein L22
Gene namesi
Name:rplV
Ordered Locus Names:BR1228, BS1330_I1224
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

GO - Cellular componenti

  1. large ribosomal subunit Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12912950S ribosomal protein L22UniRule annotation
PRO_0000125129Add
BLAST

Interactioni

Subunit structurei

Part of the 50S ribosomal subunit By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR1228.

Structurei

3D structure databases

ProteinModelPortaliQ8G080.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0091.
HOGENOMiHOG000205046.
KOiK02890.
OMAiMKRIRPR.
OrthoDBiEOG6V4GKB.

Family and domain databases

Gene3Di3.90.470.10. 1 hit.
HAMAPiMF_01331_B. Ribosomal_L22_B.
InterProiIPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERiPTHR13501. PTHR13501. 1 hit.
PfamiPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMiSSF54843. SSF54843. 1 hit.
TIGRFAMsiTIGR01044. rplV_bact. 1 hit.
PROSITEiPS00464. RIBOSOMAL_L22. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G080-1 [UniParc]FASTAAdd to Basket

« Hide

MGKAKAPRQL KDNEAKAVAR TLRVSPQKLN LVASMIRGKK VNAALADLTF    50
SRKRIAGTVK KTLESAIANA ENNHDLDVDA LIVAEAYVGK SIVMKRFHVR 100
GRGRASRIEK PFSHLTIVVR EVAEKGEAA 129
Length:129
Mass (Da):14,085
Last modified:March 1, 2003 - v1
Checksum:i937A6AA72A17F4CA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ227914 Genomic DNA. Translation: ABB77394.1.
AE014291 Genomic DNA. Translation: AAN30147.1.
CP002997 Genomic DNA. Translation: AEM18565.1.
RefSeqiNP_698232.1. NC_004310.3.
YP_005616057.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30147; AAN30147; BR1228.
AEM18565; AEM18565; BS1330_I1224.
GeneIDi1166904.
12138257.
KEGGibms:BR1228.
bsi:BS1330_I1224.
PATRICi17790793. VBIBruSui107850_1250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ227914 Genomic DNA. Translation: ABB77394.1 .
AE014291 Genomic DNA. Translation: AAN30147.1 .
CP002997 Genomic DNA. Translation: AEM18565.1 .
RefSeqi NP_698232.1. NC_004310.3.
YP_005616057.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8G080.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR1228.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN30147 ; AAN30147 ; BR1228 .
AEM18565 ; AEM18565 ; BS1330_I1224 .
GeneIDi 1166904.
12138257.
KEGGi bms:BR1228.
bsi:BS1330_I1224.
PATRICi 17790793. VBIBruSui107850_1250.

Phylogenomic databases

eggNOGi COG0091.
HOGENOMi HOG000205046.
KOi K02890.
OMAi MKRIRPR.
OrthoDBi EOG6V4GKB.

Family and domain databases

Gene3Di 3.90.470.10. 1 hit.
HAMAPi MF_01331_B. Ribosomal_L22_B.
InterProi IPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view ]
PANTHERi PTHR13501. PTHR13501. 1 hit.
Pfami PF00237. Ribosomal_L22. 1 hit.
[Graphical view ]
SUPFAMi SSF54843. SSF54843. 1 hit.
TIGRFAMsi TIGR01044. rplV_bact. 1 hit.
PROSITEi PS00464. RIBOSOMAL_L22. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications."
    Halling S.M., Jensen A.E.
    BMC Microbiol. 6:84-84(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiRL22_BRUSU
AccessioniPrimary (citable) accession number: Q8G080
Secondary accession number(s): Q075T9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: May 14, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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