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Q8G080 (RL22_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L22
Gene names
Name:rplV
Ordered Locus Names:BR1228, BS1330_I1224
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length129 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome By similarity. HAMAP-Rule MF_01331

The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome By similarity. HAMAP-Rule MF_01331

Subunit structure

Part of the 50S ribosomal subunit By similarity. HAMAP-Rule MF_01331

Sequence similarities

Belongs to the ribosomal protein L22P family.

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentlarge ribosomal subunit

Inferred from electronic annotation. Source: InterPro

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12912950S ribosomal protein L22 HAMAP-Rule MF_01331
PRO_0000125129

Sequences

Sequence LengthMass (Da)Tools
Q8G080 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 937A6AA72A17F4CA

FASTA12914,085
        10         20         30         40         50         60 
MGKAKAPRQL KDNEAKAVAR TLRVSPQKLN LVASMIRGKK VNAALADLTF SRKRIAGTVK 

        70         80         90        100        110        120 
KTLESAIANA ENNHDLDVDA LIVAEAYVGK SIVMKRFHVR GRGRASRIEK PFSHLTIVVR 


EVAEKGEAA 

« Hide

References

« Hide 'large scale' references
[1]"Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications."
Halling S.M., Jensen A.E.
BMC Microbiol. 6:84-84(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 1330.
[2]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[3]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ227914 Genomic DNA. Translation: ABB77394.1.
AE014291 Genomic DNA. Translation: AAN30147.1.
CP002997 Genomic DNA. Translation: AEM18565.1.
RefSeqNP_698232.1. NC_004310.3.
YP_005616057.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G080.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR1228.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30147; AAN30147; BR1228.
AEM18565; AEM18565; BS1330_I1224.
GeneID1166904.
12138257.
KEGGbms:BR1228.
bsi:BS1330_I1224.
PATRIC17790793. VBIBruSui107850_1250.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0091.
HOGENOMHOG000205046.
KOK02890.
OMAGRAFRIN.
OrthoDBEOG6V4GKB.
ProtClustDBPRK00565.

Family and domain databases

Gene3D3.90.470.10. 1 hit.
HAMAPMF_01331_B. Ribosomal_L22_B.
InterProIPR001063. Ribosomal_L22.
IPR018260. Ribosomal_L22/L17_CS.
IPR005727. Ribosomal_L22_bac/chlpt-type.
[Graphical view]
PANTHERPTHR13501. PTHR13501. 1 hit.
PfamPF00237. Ribosomal_L22. 1 hit.
[Graphical view]
SUPFAMSSF54843. SSF54843. 1 hit.
TIGRFAMsTIGR01044. rplV_bact. 1 hit.
PROSITEPS00464. RIBOSOMAL_L22. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRL22_BRUSU
AccessionPrimary (citable) accession number: Q8G080
Secondary accession number(s): Q075T9
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

Brucella suis

Brucella suis (strain 1330): entries and gene names