Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8G077 (RL4_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
50S ribosomal protein L4
Gene names
Name:rplD
Ordered Locus Names:BR1232, BS1330_I1228
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length206 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome By similarity. HAMAP-Rule MF_01328

Forms part of the polypeptide exit tunnel By similarity. HAMAP-Rule MF_01328

Subunit structure

Part of the 50S ribosomal subunit By similarity. HAMAP-Rule MF_01328

Sequence similarities

Belongs to the ribosomal protein L4P family.

Ontologies

Keywords
   LigandRNA-binding
rRNA-binding
   Molecular functionRibonucleoprotein
Ribosomal protein
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranslation

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentribosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionrRNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

structural constituent of ribosome

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 20620650S ribosomal protein L4 HAMAP-Rule MF_01328
PRO_0000129194

Sequences

Sequence LengthMass (Da)Tools
Q8G077 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 1CE73FA611BD2557

FASTA20622,561
        10         20         30         40         50         60 
MDLTITTLEG KDAGKVKLNE EIFGLDPRDD ILQRVVRWQL ARRQQGSHKA QGRGDVSRTG 

        70         80         90        100        110        120 
SKMYKQKGTG RARHHSARAP QFRGGGQAHG PVVRNHDHDL PKKVRALGLR HALSAKAKAS 

       130        140        150        160        170        180 
DLIIIDDLAS ADAKTKQLVS QFAKLGLENA LLIGGAEIDA NFQRAASNIP NIDVLPVQGI 

       190        200 
NVYDILRRGK LVLSKAAVEA LEERFK 

« Hide

References

« Hide 'large scale' references
[1]"Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications."
Halling S.M., Jensen A.E.
BMC Microbiol. 6:84-84(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: 1330.
[2]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[3]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ289570 Genomic DNA. Translation: ABB91848.1.
AE014291 Genomic DNA. Translation: AAN30151.1.
CP002997 Genomic DNA. Translation: AEM18569.1.
RefSeqNP_698236.1. NC_004310.3.
YP_005616061.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G077.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR1232.

Proteomic databases

PRIDEQ8G077.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30151; AAN30151; BR1232.
AEM18569; AEM18569; BS1330_I1228.
GeneID1166908.
12138261.
KEGGbms:BR1232.
bsi:BS1330_I1228.
PATRIC17790801. VBIBruSui107850_1254.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0088.
HOGENOMHOG000248767.
KOK02926.
OMAVVRSHEH.
OrthoDBEOG6M0T9G.
ProtClustDBPRK05319.

Family and domain databases

Gene3D3.40.1370.10. 1 hit.
HAMAPMF_01328_B. Ribosomal_L4_B.
InterProIPR002136. Ribosomal_L4/L1e.
IPR013005. Ribosomal_L4/L1e_bac-type.
IPR023574. Ribosomal_L4_dom.
[Graphical view]
PANTHERPTHR10746. PTHR10746. 1 hit.
PfamPF00573. Ribosomal_L4. 1 hit.
[Graphical view]
SUPFAMSSF52166. SSF52166. 1 hit.
TIGRFAMsTIGR03953. rplD_bact. 1 hit.
ProtoNetSearch...

Entry information

Entry nameRL4_BRUSU
AccessionPrimary (citable) accession number: Q8G077
Secondary accession number(s): Q072A6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Ribosomal proteins

Ribosomal proteins families and list of entries

Brucella suis

Brucella suis (strain 1330): entries and gene names