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Q8G077

- RL4_BRUSU

UniProt

Q8G077 - RL4_BRUSU

Protein

50S ribosomal protein L4

Gene

rplD

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.UniRule annotation
    Forms part of the polypeptide exit tunnel.UniRule annotation

    GO - Molecular functioni

    1. rRNA binding Source: UniProtKB-HAMAP
    2. structural constituent of ribosome Source: InterPro

    GO - Biological processi

    1. translation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Keywords - Ligandi

    RNA-binding, rRNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    50S ribosomal protein L4UniRule annotation
    Gene namesi
    Name:rplDUniRule annotation
    Ordered Locus Names:BR1232, BS1330_I1228
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    GO - Cellular componenti

    1. ribosome Source: UniProtKB-KW

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 20620650S ribosomal protein L4PRO_0000129194Add
    BLAST

    Proteomic databases

    PRIDEiQ8G077.

    Interactioni

    Subunit structurei

    Part of the 50S ribosomal subunit.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR1232.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G077.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein L4P family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0088.
    HOGENOMiHOG000248767.
    KOiK02926.
    OMAiILNHECV.
    OrthoDBiEOG6M0T9G.

    Family and domain databases

    Gene3Di3.40.1370.10. 1 hit.
    HAMAPiMF_01328_B. Ribosomal_L4_B.
    InterProiIPR002136. Ribosomal_L4/L1e.
    IPR013005. Ribosomal_L4/L1e_bac-type.
    IPR023574. Ribosomal_L4_dom.
    [Graphical view]
    PANTHERiPTHR10746. PTHR10746. 1 hit.
    PfamiPF00573. Ribosomal_L4. 1 hit.
    [Graphical view]
    SUPFAMiSSF52166. SSF52166. 1 hit.
    TIGRFAMsiTIGR03953. rplD_bact. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8G077-1 [UniParc]FASTAAdd to Basket

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    MDLTITTLEG KDAGKVKLNE EIFGLDPRDD ILQRVVRWQL ARRQQGSHKA    50
    QGRGDVSRTG SKMYKQKGTG RARHHSARAP QFRGGGQAHG PVVRNHDHDL 100
    PKKVRALGLR HALSAKAKAS DLIIIDDLAS ADAKTKQLVS QFAKLGLENA 150
    LLIGGAEIDA NFQRAASNIP NIDVLPVQGI NVYDILRRGK LVLSKAAVEA 200
    LEERFK 206
    Length:206
    Mass (Da):22,561
    Last modified:March 1, 2003 - v1
    Checksum:i1CE73FA611BD2557
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ289570 Genomic DNA. Translation: ABB91848.1.
    AE014291 Genomic DNA. Translation: AAN30151.1.
    CP002997 Genomic DNA. Translation: AEM18569.1.
    RefSeqiNP_698236.1. NC_004310.3.
    YP_005616061.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30151; AAN30151; BR1232.
    AEM18569; AEM18569; BS1330_I1228.
    GeneIDi1166908.
    12138261.
    KEGGibms:BR1232.
    bsi:BS1330_I1228.
    PATRICi17790801. VBIBruSui107850_1254.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ289570 Genomic DNA. Translation: ABB91848.1 .
    AE014291 Genomic DNA. Translation: AAN30151.1 .
    CP002997 Genomic DNA. Translation: AEM18569.1 .
    RefSeqi NP_698236.1. NC_004310.3.
    YP_005616061.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G077.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1232.

    Proteomic databases

    PRIDEi Q8G077.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30151 ; AAN30151 ; BR1232 .
    AEM18569 ; AEM18569 ; BS1330_I1228 .
    GeneIDi 1166908.
    12138261.
    KEGGi bms:BR1232.
    bsi:BS1330_I1228.
    PATRICi 17790801. VBIBruSui107850_1254.

    Phylogenomic databases

    eggNOGi COG0088.
    HOGENOMi HOG000248767.
    KOi K02926.
    OMAi ILNHECV.
    OrthoDBi EOG6M0T9G.

    Family and domain databases

    Gene3Di 3.40.1370.10. 1 hit.
    HAMAPi MF_01328_B. Ribosomal_L4_B.
    InterProi IPR002136. Ribosomal_L4/L1e.
    IPR013005. Ribosomal_L4/L1e_bac-type.
    IPR023574. Ribosomal_L4_dom.
    [Graphical view ]
    PANTHERi PTHR10746. PTHR10746. 1 hit.
    Pfami PF00573. Ribosomal_L4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52166. SSF52166. 1 hit.
    TIGRFAMsi TIGR03953. rplD_bact. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Intrinsic and selected resistance to antibiotics binding the ribosome: analyses of Brucella 23S rrn, L4, L22, EF-Tu1, EF-Tu2, efflux and phylogenetic implications."
      Halling S.M., Jensen A.E.
      BMC Microbiol. 6:84-84(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiRL4_BRUSU
    AccessioniPrimary (citable) accession number: Q8G077
    Secondary accession number(s): Q072A6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 26, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. Ribosomal proteins
      Ribosomal proteins families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3