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Q8G075

- EFG_BRUSU

UniProt

Q8G075 - EFG_BRUSU

Protein

Elongation factor G

Gene

fusA

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.UniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 248GTPUniRule annotation
    Nucleotide bindingi86 – 905GTPUniRule annotation
    Nucleotide bindingi140 – 1434GTPUniRule annotation

    GO - Molecular functioni

    1. GTPase activity Source: InterPro
    2. GTP binding Source: UniProtKB-HAMAP
    3. translation elongation factor activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Elongation factor

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Elongation factor GUniRule annotation
    Short name:
    EF-GUniRule annotation
    Gene namesi
    Name:fusAUniRule annotation
    Ordered Locus Names:BR1236, BS1330_I1232
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 694694Elongation factor GPRO_0000091089Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi204722.BR1236.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G075.
    SMRiQ8G075. Positions 4-691.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini8 – 287280tr-type GAdd
    BLAST

    Sequence similaritiesi

    Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0480.
    HOGENOMiHOG000231585.
    KOiK02355.
    OMAiSGVQPQT.
    OrthoDBiEOG6X6RBF.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.240. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPiMF_00054_B. EF_G_EF_2_B.
    InterProiIPR000795. EF_GTP-bd_dom.
    IPR009022. EFG_III-V.
    IPR000640. EFG_V.
    IPR027417. P-loop_NTPase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR004540. Transl_elong_EFG/EF2.
    IPR005517. Transl_elong_EFG/EF2_IV.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view]
    PfamiPF00679. EFG_C. 1 hit.
    PF14492. EFG_II. 1 hit.
    PF03764. EFG_IV. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    [Graphical view]
    PRINTSiPR00315. ELONGATNFCT.
    SMARTiSM00838. EFG_C. 1 hit.
    SM00889. EFG_IV. 1 hit.
    [Graphical view]
    SUPFAMiSSF50447. SSF50447. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF54980. SSF54980. 2 hits.
    TIGRFAMsiTIGR00484. EF-G. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEiPS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G075-1 [UniParc]FASTAAdd to Basket

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    MAREYKIEDY RNFGIMAHID AGKTTMTERI LFYTGKNHKI GETHDGASTM    50
    DWMEQEQERG ITITSAATTT FWQGRDGKKR RFNIIDTPGH VDFTIEVERS 100
    LRVLDGAIAL LDANAGVEPQ TETVWRQAEK YHVPRMVFVN KMDKIGADFY 150
    RSVEMVGSRL GAVALPVQLP IGAENDFVGV VDLIEMKALT WDGTIGAPAT 200
    VGEIPADMAD KAEEYREKLI ELAVEIDEAA MEAYLEGTMP TNDELRALIR 250
    KGTIEVKFHP ILCGTAFKNR GVQPLLDAVV EFLPAPTDVP AIKGIDVKTE 300
    TETTRESSDE APLSMLAFKI MNDPFVGSLT FARIYSGKLT KGVSLENTVK 350
    GKRERIGRML QMHSNSREDI DEAFAGDIVA LAGLKETTTG DTLCDPLKPV 400
    ILERMEFPDP VIEIAIEPKT KADQEKMGIA LNRLAAEDPS FRVKSDEESG 450
    QTIIAGMGEL HLDILVDRMK REFKVEANVG APQVAYRESI TRAAEIDYTH 500
    KKQSGGSGQF ARVKIIFEPH DGDDFIFESK IVGGSVPKEY IPGVQKGIES 550
    VMGAGPLAGF PMLGVKATLI DGAYHDVDSS VLAFEIASRA AFREGAQKAG 600
    AQLLEPIMKV EVVTPEDYVG DVIGDLNSRR GQISGTEARG IATVVNAMVP 650
    LANMFGYVNS LRSMSQGRAQ YTMQFDHYEP VPTAVAQEIQ KKFA 694
    Length:694
    Mass (Da):76,265
    Last modified:March 1, 2003 - v1
    Checksum:i1EC9ABC88B769A59
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30155.1.
    CP002997 Genomic DNA. Translation: AEM18573.1.
    RefSeqiNP_698240.1. NC_004310.3.
    YP_005616065.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30155; AAN30155; BR1236.
    AEM18573; AEM18573; BS1330_I1232.
    GeneIDi1166912.
    12138265.
    KEGGibms:BR1236.
    bsi:BS1330_I1232.
    PATRICi17790809. VBIBruSui107850_1258.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30155.1 .
    CP002997 Genomic DNA. Translation: AEM18573.1 .
    RefSeqi NP_698240.1. NC_004310.3.
    YP_005616065.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G075.
    SMRi Q8G075. Positions 4-691.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1236.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30155 ; AAN30155 ; BR1236 .
    AEM18573 ; AEM18573 ; BS1330_I1232 .
    GeneIDi 1166912.
    12138265.
    KEGGi bms:BR1236.
    bsi:BS1330_I1232.
    PATRICi 17790809. VBIBruSui107850_1258.

    Phylogenomic databases

    eggNOGi COG0480.
    HOGENOMi HOG000231585.
    KOi K02355.
    OMAi SGVQPQT.
    OrthoDBi EOG6X6RBF.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.240. 1 hit.
    3.40.50.300. 1 hit.
    HAMAPi MF_00054_B. EF_G_EF_2_B.
    InterProi IPR000795. EF_GTP-bd_dom.
    IPR009022. EFG_III-V.
    IPR000640. EFG_V.
    IPR027417. P-loop_NTPase.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    IPR005225. Small_GTP-bd_dom.
    IPR009000. Transl_B-barrel.
    IPR004540. Transl_elong_EFG/EF2.
    IPR005517. Transl_elong_EFG/EF2_IV.
    IPR004161. Transl_elong_EFTu/EF1A_2.
    [Graphical view ]
    Pfami PF00679. EFG_C. 1 hit.
    PF14492. EFG_II. 1 hit.
    PF03764. EFG_IV. 1 hit.
    PF00009. GTP_EFTU. 1 hit.
    PF03144. GTP_EFTU_D2. 1 hit.
    [Graphical view ]
    PRINTSi PR00315. ELONGATNFCT.
    SMARTi SM00838. EFG_C. 1 hit.
    SM00889. EFG_IV. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50447. SSF50447. 1 hit.
    SSF52540. SSF52540. 1 hit.
    SSF54211. SSF54211. 1 hit.
    SSF54980. SSF54980. 2 hits.
    TIGRFAMsi TIGR00484. EF-G. 1 hit.
    TIGR00231. small_GTP. 1 hit.
    PROSITEi PS00301. G_TR_1. 1 hit.
    PS51722. G_TR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiEFG_BRUSU
    AccessioniPrimary (citable) accession number: Q8G075
    Secondary accession number(s): G0KAF7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 29, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3