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Q8G069

- RPOB_BRUSU

UniProt

Q8G069 - RPOB_BRUSU

Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

    Catalytic activityi

    Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-HAMAP
    2. DNA-directed RNA polymerase activity Source: UniProtKB-HAMAP
    3. ribonucleoside binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Transcription

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
    Short name:
    RNAP subunit betaUniRule annotation
    Alternative name(s):
    RNA polymerase subunit betaUniRule annotation
    Transcriptase subunit betaUniRule annotation
    Gene namesi
    Name:rpoBUniRule annotation
    Ordered Locus Names:BR1243, BS1330_I1239
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Keywords - Cellular componenti

    DNA-directed RNA polymerase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13771377DNA-directed RNA polymerase subunit betaPRO_0000047871Add
    BLAST

    Interactioni

    Subunit structurei

    The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR1243.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8G069.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the RNA polymerase beta chain family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0085.
    HOGENOMiHOG000218612.
    KOiK03043.
    OMAiFPITDFS.
    OrthoDBiEOG6M9DS6.

    Family and domain databases

    Gene3Di2.30.150.10. 1 hit.
    2.40.270.10. 2 hits.
    2.40.50.150. 2 hits.
    3.90.1110.10. 2 hits.
    HAMAPiMF_01321. RNApol_bact_RpoB.
    InterProiIPR010243. DNA-dir_RNA_pol_bsu.
    IPR019462. DNA-dir_RNA_pol_bsu_external_1.
    IPR015712. DNA-dir_RNA_pol_su2.
    IPR007120. DNA-dir_RNA_pol_su2_6.
    IPR007121. RNA_pol_bsu_CS.
    IPR007644. RNA_pol_bsu_protrusion.
    IPR007642. RNA_pol_Rpb2_2.
    IPR007645. RNA_pol_Rpb2_3.
    IPR007641. RNA_pol_Rpb2_7.
    IPR014724. RNA_pol_RPB2_OB-fold.
    [Graphical view]
    PANTHERiPTHR20856. PTHR20856. 1 hit.
    PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
    PF04561. RNA_pol_Rpb2_2. 2 hits.
    PF04565. RNA_pol_Rpb2_3. 1 hit.
    PF10385. RNA_pol_Rpb2_45. 1 hit.
    PF00562. RNA_pol_Rpb2_6. 1 hit.
    PF04560. RNA_pol_Rpb2_7. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR02013. rpoB. 1 hit.
    PROSITEiPS01166. RNA_POL_BETA. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8G069-1 [UniParc]FASTAAdd to Basket

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    MAQTHSFNGR KRVRKFFGKI PEVAEMPNLI EVQKASYDQF LMVEEPSGGR     50
    PDEGLQAVFK SVFPIQDFSG ASMLEFVRYE FDPPKFDVDE CRQRDLTYSA 100
    PLKVTLRLIV FDIDEDTGAK SIKDIKEQDV YMGDMPLMTD NGTFIVNGTE 150
    RVIVSQMHRS PGVFFDHDKG KTHSSGKLLF AARVIPYRGS WLDIEFDSKD 200
    IVYARIDRRR KLPATTLLMA LGMDGEEILS TFYKTVTYTR DGDNWRIPYS 250
    AERFKGMKII SDLVDADTGE AVLEAGKKLT ARAAKQLAEK GLKAIKATED 300
    DLFGSYLAED VVNYATGEIY LEAGDEIDEK VLKTLIDTGE TEINVLDIDH 350
    VNIGAYIRNT LAVDKNESRQ EALFDIYRVM RPGEPPTMDS AEAMFHSLFF 400
    DSERYDLSAV GRVKMNMRLD LDAEDTVRVL RKEDILAVVK MLVELRDGRG 450
    EIDDIDNLGN RRVRSVGELM ENQYRVGLLR MERAIKERMS SIEIDTVMPQ 500
    DLINAKPAAA AVREFFGSSQ LSQFMDQTNP LSEITHKRRL SALGPGGLTR 550
    ERAGFEVRDV HPTHYGRICP IETPEGPNIG LINSLATFAR VNKYGFIESP 600
    YRKVVDGKVT NDVVYLSAME EAKHSVAQAN VELDEQGGFV DEFVICRHAG 650
    EVMMAPRENV DLMDVSPKQL VSVAAALIPF LENDDANRAL MGSNMQRQAV 700
    PLVRAEAPFV GTGMEPIVAR DSGAAIAARR GGIVDQVDAT RIVIRATEEL 750
    DPSKSGVDIY RLQKFQRSNQ STCINQRPLV RVGDRIHKGD IIADGPSTDL 800
    GDLALGRNVL VAFMPWNGYN YEDSILLSEK IVSDDVFTSI HIEEFEVAAR 850
    DTKLGPEEIT RDIPNVSEEA LKNLDEAGIV YIGAEVHPGD ILVGKITPKG 900
    ESPMTPEEKL LRAIFGEKAS DVRDTSMRMP PGTYGTVVEV RVFNRHGVEK 950
    DERAMAIERE EIERLAKDRD DEQAILDRNV YGRLADMIDG KVAAAGPKGF 1000
    KKGTTITREL MTEYPRSQWW QFAVEDEKLQ GELEALRSQY DDSKKLLEAR 1050
    FMDKVEKVQR GDEMPPGVMK MVKVFVAVKR KIQPGDKMAG RHGNKGVVSR 1100
    ILPVEDMPFL EDGTHADIVL NPLGVPSRMN VGQILETHLG WACAGMGKKI 1150
    GELLDVYRKT ANIEPLRQTL EHIYPDNDRN EPVRSYDDDA ILMLANQVKR 1200
    GVSIATPVFD GAVEADINAM LTDAGLATSG QSTLYDGRTG EPFDRQVTMG 1250
    YIYMLKLHHL VDDKIHARSI GPYSLVTQQP LGGKAQFGGQ RFGEMEVWAL 1300
    EAYGAAYTLQ EMLTVKSDDV AGRTKVYEAI VRGDDTFEAG IPESFNVLVK 1350
    EMRSLGLNVE LDDTREAEQP ALPDAAE 1377
    Length:1,377
    Mass (Da):153,641
    Last modified:March 1, 2003 - v1
    Checksum:i5523F3E2A260F57F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30162.1.
    CP002997 Genomic DNA. Translation: AEM18580.1.
    RefSeqiNP_698247.1. NC_004310.3.
    YP_005616072.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30162; AAN30162; BR1243.
    AEM18580; AEM18580; BS1330_I1239.
    GeneIDi1166919.
    12138272.
    KEGGibms:BR1243.
    bsi:BS1330_I1239.
    PATRICi17790823. VBIBruSui107850_1265.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30162.1 .
    CP002997 Genomic DNA. Translation: AEM18580.1 .
    RefSeqi NP_698247.1. NC_004310.3.
    YP_005616072.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8G069.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1243.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30162 ; AAN30162 ; BR1243 .
    AEM18580 ; AEM18580 ; BS1330_I1239 .
    GeneIDi 1166919.
    12138272.
    KEGGi bms:BR1243.
    bsi:BS1330_I1239.
    PATRICi 17790823. VBIBruSui107850_1265.

    Phylogenomic databases

    eggNOGi COG0085.
    HOGENOMi HOG000218612.
    KOi K03043.
    OMAi FPITDFS.
    OrthoDBi EOG6M9DS6.

    Miscellaneous databases

    PROi Q8G069.

    Family and domain databases

    Gene3Di 2.30.150.10. 1 hit.
    2.40.270.10. 2 hits.
    2.40.50.150. 2 hits.
    3.90.1110.10. 2 hits.
    HAMAPi MF_01321. RNApol_bact_RpoB.
    InterProi IPR010243. DNA-dir_RNA_pol_bsu.
    IPR019462. DNA-dir_RNA_pol_bsu_external_1.
    IPR015712. DNA-dir_RNA_pol_su2.
    IPR007120. DNA-dir_RNA_pol_su2_6.
    IPR007121. RNA_pol_bsu_CS.
    IPR007644. RNA_pol_bsu_protrusion.
    IPR007642. RNA_pol_Rpb2_2.
    IPR007645. RNA_pol_Rpb2_3.
    IPR007641. RNA_pol_Rpb2_7.
    IPR014724. RNA_pol_RPB2_OB-fold.
    [Graphical view ]
    PANTHERi PTHR20856. PTHR20856. 1 hit.
    Pfami PF04563. RNA_pol_Rpb2_1. 1 hit.
    PF04561. RNA_pol_Rpb2_2. 2 hits.
    PF04565. RNA_pol_Rpb2_3. 1 hit.
    PF10385. RNA_pol_Rpb2_45. 1 hit.
    PF00562. RNA_pol_Rpb2_6. 1 hit.
    PF04560. RNA_pol_Rpb2_7. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR02013. rpoB. 1 hit.
    PROSITEi PS01166. RNA_POL_BETA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiRPOB_BRUSU
    AccessioniPrimary (citable) accession number: Q8G069
    Secondary accession number(s): G0KAG4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 16, 2004
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3