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Protein

DNA-directed RNA polymerase subunit beta

Gene

rpoB

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Transcription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit betaUniRule annotation (EC:2.7.7.6UniRule annotation)
Short name:
RNAP subunit betaUniRule annotation
Alternative name(s):
RNA polymerase subunit betaUniRule annotation
Transcriptase subunit betaUniRule annotation
Gene namesi
Name:rpoBUniRule annotation
Ordered Locus Names:BR1243, BS1330_I1239
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13771377DNA-directed RNA polymerase subunit betaPRO_0000047871Add
BLAST

Interactioni

Subunit structurei

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ8G069.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNA polymerase beta chain family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0085.
HOGENOMiHOG000218612.
KOiK03043.
OMAiLETHHRI.
OrthoDBiEOG6M9DS6.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 2 hits.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8G069-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQTHSFNGR KRVRKFFGKI PEVAEMPNLI EVQKASYDQF LMVEEPSGGR
60 70 80 90 100
PDEGLQAVFK SVFPIQDFSG ASMLEFVRYE FDPPKFDVDE CRQRDLTYSA
110 120 130 140 150
PLKVTLRLIV FDIDEDTGAK SIKDIKEQDV YMGDMPLMTD NGTFIVNGTE
160 170 180 190 200
RVIVSQMHRS PGVFFDHDKG KTHSSGKLLF AARVIPYRGS WLDIEFDSKD
210 220 230 240 250
IVYARIDRRR KLPATTLLMA LGMDGEEILS TFYKTVTYTR DGDNWRIPYS
260 270 280 290 300
AERFKGMKII SDLVDADTGE AVLEAGKKLT ARAAKQLAEK GLKAIKATED
310 320 330 340 350
DLFGSYLAED VVNYATGEIY LEAGDEIDEK VLKTLIDTGE TEINVLDIDH
360 370 380 390 400
VNIGAYIRNT LAVDKNESRQ EALFDIYRVM RPGEPPTMDS AEAMFHSLFF
410 420 430 440 450
DSERYDLSAV GRVKMNMRLD LDAEDTVRVL RKEDILAVVK MLVELRDGRG
460 470 480 490 500
EIDDIDNLGN RRVRSVGELM ENQYRVGLLR MERAIKERMS SIEIDTVMPQ
510 520 530 540 550
DLINAKPAAA AVREFFGSSQ LSQFMDQTNP LSEITHKRRL SALGPGGLTR
560 570 580 590 600
ERAGFEVRDV HPTHYGRICP IETPEGPNIG LINSLATFAR VNKYGFIESP
610 620 630 640 650
YRKVVDGKVT NDVVYLSAME EAKHSVAQAN VELDEQGGFV DEFVICRHAG
660 670 680 690 700
EVMMAPRENV DLMDVSPKQL VSVAAALIPF LENDDANRAL MGSNMQRQAV
710 720 730 740 750
PLVRAEAPFV GTGMEPIVAR DSGAAIAARR GGIVDQVDAT RIVIRATEEL
760 770 780 790 800
DPSKSGVDIY RLQKFQRSNQ STCINQRPLV RVGDRIHKGD IIADGPSTDL
810 820 830 840 850
GDLALGRNVL VAFMPWNGYN YEDSILLSEK IVSDDVFTSI HIEEFEVAAR
860 870 880 890 900
DTKLGPEEIT RDIPNVSEEA LKNLDEAGIV YIGAEVHPGD ILVGKITPKG
910 920 930 940 950
ESPMTPEEKL LRAIFGEKAS DVRDTSMRMP PGTYGTVVEV RVFNRHGVEK
960 970 980 990 1000
DERAMAIERE EIERLAKDRD DEQAILDRNV YGRLADMIDG KVAAAGPKGF
1010 1020 1030 1040 1050
KKGTTITREL MTEYPRSQWW QFAVEDEKLQ GELEALRSQY DDSKKLLEAR
1060 1070 1080 1090 1100
FMDKVEKVQR GDEMPPGVMK MVKVFVAVKR KIQPGDKMAG RHGNKGVVSR
1110 1120 1130 1140 1150
ILPVEDMPFL EDGTHADIVL NPLGVPSRMN VGQILETHLG WACAGMGKKI
1160 1170 1180 1190 1200
GELLDVYRKT ANIEPLRQTL EHIYPDNDRN EPVRSYDDDA ILMLANQVKR
1210 1220 1230 1240 1250
GVSIATPVFD GAVEADINAM LTDAGLATSG QSTLYDGRTG EPFDRQVTMG
1260 1270 1280 1290 1300
YIYMLKLHHL VDDKIHARSI GPYSLVTQQP LGGKAQFGGQ RFGEMEVWAL
1310 1320 1330 1340 1350
EAYGAAYTLQ EMLTVKSDDV AGRTKVYEAI VRGDDTFEAG IPESFNVLVK
1360 1370
EMRSLGLNVE LDDTREAEQP ALPDAAE
Length:1,377
Mass (Da):153,641
Last modified:March 1, 2003 - v1
Checksum:i5523F3E2A260F57F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30162.1.
CP002997 Genomic DNA. Translation: AEM18580.1.
RefSeqiNP_698247.1. NC_004310.3.
WP_006190505.1. NZ_KN046804.1.
YP_005616072.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30162; AAN30162; BR1243.
AEM18580; AEM18580; BS1330_I1239.
KEGGibms:BR1243.
bsi:BS1330_I1239.
PATRICi17790823. VBIBruSui107850_1265.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30162.1.
CP002997 Genomic DNA. Translation: AEM18580.1.
RefSeqiNP_698247.1. NC_004310.3.
WP_006190505.1. NZ_KN046804.1.
YP_005616072.1. NC_017251.1.

3D structure databases

ProteinModelPortaliQ8G069.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN30162; AAN30162; BR1243.
AEM18580; AEM18580; BS1330_I1239.
KEGGibms:BR1243.
bsi:BS1330_I1239.
PATRICi17790823. VBIBruSui107850_1265.

Phylogenomic databases

eggNOGiCOG0085.
HOGENOMiHOG000218612.
KOiK03043.
OMAiLETHHRI.
OrthoDBiEOG6M9DS6.

Miscellaneous databases

PROiQ8G069.

Family and domain databases

Gene3Di2.30.150.10. 1 hit.
2.40.270.10. 2 hits.
2.40.50.150. 2 hits.
3.90.1110.10. 2 hits.
HAMAPiMF_01321. RNApol_bact_RpoB.
InterProiIPR010243. DNA-dir_RNA_pol_bsu.
IPR019462. DNA-dir_RNA_pol_bsu_external_1.
IPR015712. DNA-dir_RNA_pol_su2.
IPR007120. DNA-dir_RNA_pol_su2_6.
IPR007121. RNA_pol_bsu_CS.
IPR007644. RNA_pol_bsu_protrusion.
IPR007642. RNA_pol_Rpb2_2.
IPR007645. RNA_pol_Rpb2_3.
IPR007641. RNA_pol_Rpb2_7.
IPR014724. RNA_pol_RPB2_OB-fold.
[Graphical view]
PANTHERiPTHR20856. PTHR20856. 1 hit.
PfamiPF04563. RNA_pol_Rpb2_1. 1 hit.
PF04561. RNA_pol_Rpb2_2. 2 hits.
PF04565. RNA_pol_Rpb2_3. 1 hit.
PF10385. RNA_pol_Rpb2_45. 1 hit.
PF00562. RNA_pol_Rpb2_6. 1 hit.
PF04560. RNA_pol_Rpb2_7. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02013. rpoB. 1 hit.
PROSITEiPS01166. RNA_POL_BETA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiRPOB_BRUSU
AccessioniPrimary (citable) accession number: Q8G069
Secondary accession number(s): G0KAG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.