Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8G020 (COBB_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cobyrinic acid A,C-diamide synthase
Gene names
Name:cobB
Ordered Locus Names:BR1296, BS1330_I1292
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length436 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation By similarity. HAMAP-Rule MF_00027

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis. HAMAP-Rule MF_00027

Sequence similarities

Belongs to the CobB/CobQ family. CobB subfamily.

Contains 1 GATase cobBQ-type domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 436436Cobyrinic acid A,C-diamide synthase HAMAP-Rule MF_00027
PRO_0000141256

Regions

Domain244 – 435192GATase cobBQ-type

Sites

Active site3271Nucleophile By similarity
Active site4271 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8G020 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 84D839B378FFB37F

FASTA43646,962
        10         20         30         40         50         60 
MKGFMIAAPA SGSGKTTVTL GLLRALKRRG EVLAPVKAGP DYIDPAYHRA ASGVDCFNLD 

        70         80         90        100        110        120 
PWAMRPGLIS ALSSRMTESG ARVLVAEGMM GLFDGAIDGK GSSADLARLL DLPVVLVVDC 

       130        140        150        160        170        180 
ARQSHSIAAL VWGFSQFRKD VLIEGVILNR VGSPRHEAML RGALAPLGVP VLGALPRDPA 

       190        200        210        220        230        240 
LSLPERHLGL VQADEHAGLE SFLEQAADVM EAHIDMDALQ TIWLRPKRYD AMANVARLKP 

       250        260        270        280        290        300 
LGNRIAVARD DAFAFAYMHL FEGWRRRGAE ISFFSPLADE APKADADAIY LPGGYPELHA 

       310        320        330        340        350        360 
QRLAGASRFR TAIGDAAARG VTVYGECGGY MVLGKTLEDA AGVHHPMLGL LPLETSFARR 

       370        380        390        400        410        420 
KLHLGYRLLE PLGGLPWDMP LKAHEFHYAS IVREEKADRL FRVRDASGEN LGEAGLRVGS 

       430 
VSGSFMHVID FSGEAA 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN30214.1.
CP002997 Genomic DNA. Translation: AEM18632.1.
RefSeqNP_698299.1. NC_004310.3.
YP_005616124.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8G020.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR1296.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30214; AAN30214; BR1296.
AEM18632; AEM18632; BS1330_I1292.
GeneID1166977.
12138330.
KEGGbms:BR1296.
bsi:BS1330_I1292.
PATRIC17790939. VBIBruSui107850_1318.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1797.
HOGENOMHOG000289959.
KOK02224.
OMACWLPGGY.
OrthoDBEOG6X6R8V.
ProtClustDBPRK01077.

Enzyme and pathway databases

UniPathwayUPA00148.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00027. CobB.
InterProIPR004484. CbiA_synth.
IPR017929. CobB/CobQ_GATase.
IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR011698. GATase_3.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01656. CbiA. 1 hit.
PF07685. GATase_3. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00379. cobB. 1 hit.
PROSITEPS51274. GATASE_COBBQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8G020.

Entry information

Entry nameCOBB_BRUSU
AccessionPrimary (citable) accession number: Q8G020
Secondary accession number(s): G0KAQ5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names