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Protein

Urease accessory protein UreD 2

Gene

ureD2

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Required for maturation of urease via the functional incorporation of the urease nickel metallocenter.UniRule annotation
Disrupting the ure2 operon has no effect on urease activity, or pathogen survival in BALB/c mice when innoculated by gavage, but confers slightly enhanced resistance to low pH killing in vitro.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chaperone

Keywords - Biological processi

Nickel insertion

Names & Taxonomyi

Protein namesi
Recommended name:
Urease accessory protein UreD 2UniRule annotation
Gene namesi
Name:ureD2UniRule annotation
Synonyms:ureD-2
Ordered Locus Names:BR1362, BS1330_I1357
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000007104 Componenti: Chromosome I

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Urease accessory protein UreD 2PRO_0000340428Add
BLAST

Interactioni

Subunit structurei

UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel.UniRule annotation

Family & Domainsi

Sequence similaritiesi

Belongs to the UreD family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0829.
HOGENOMiHOG000060675.
KOiK03190.
OMAiQENIVFN.
OrthoDBiEOG690MJ6.

Family and domain databases

HAMAPiMF_01384. UreD.
InterProiIPR002669. UreD.
[Graphical view]
PfamiPF01774. UreD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FZV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGKARELAN YQDEPEQLPT GSFGKNAFLR LGFERRPERT VLATLHRRAP
60 70 80 90 100
LIVQQALYWD EGMPTLPCVS IISNAGGILQ GDRYAIEIDL EPDTQAHVTT
110 120 130 140 150
QSATRIQEMD ANFATQTQTI TLGANSYLEY IPHPIIPHKH SRFVQQTEVT
160 170 180 190 200
IHPTATLIYS EVLMAGRKYY GTGELFHYDL FSSKFHAAHT DGTSLFTEKF
210 220 230 240 250
IVEPARGNVS RLGAMGSFHV FGNLILLTPK THADRLFETI DPVFDMDEGI
260 270 280 290 300
AWGASRLPND AGLLFKVLGM ESAPVRAAIR KIWEAARQEV TGASLPENFL

WA
Length:302
Mass (Da):33,685
Last modified:March 1, 2003 - v1
Checksum:iBD228D3B2E437E06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30276.1.
CP002997 Genomic DNA. Translation: AEM18693.1.
PIRiAE3332.
RefSeqiNP_698361.1. NC_004310.3.
WP_002967786.1. NZ_KN046804.1.
YP_005616185.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30276; AAN30276; BR1362.
AEM18693; AEM18693; BS1330_I1357.
KEGGibms:BR1362.
bsi:BS1330_I1357.
PATRICi17791075. VBIBruSui107850_1384.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30276.1.
CP002997 Genomic DNA. Translation: AEM18693.1.
PIRiAE3332.
RefSeqiNP_698361.1. NC_004310.3.
WP_002967786.1. NZ_KN046804.1.
YP_005616185.1. NC_017251.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN30276; AAN30276; BR1362.
AEM18693; AEM18693; BS1330_I1357.
KEGGibms:BR1362.
bsi:BS1330_I1357.
PATRICi17791075. VBIBruSui107850_1384.

Phylogenomic databases

eggNOGiCOG0829.
HOGENOMiHOG000060675.
KOiK03190.
OMAiQENIVFN.
OrthoDBiEOG690MJ6.

Family and domain databases

HAMAPiMF_01384. UreD.
InterProiIPR002669. UreD.
[Graphical view]
PfamiPF01774. UreD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  3. "Brucella suis urease encoded by ure1 but not ure2 is necessary for intestinal infection of BALB/c mice."
    Bandara A.B., Contreras A., Contreras-Rodriguez A., Martins A.M., Dobrean V., Poff-Reichow S., Rajasekaran P., Sriranganathan N., Schurig G.G., Boyle S.M.
    BMC Microbiol. 7:57-57(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: OPERON DISRUPTION, LACK OF ROLE IN VIRULENCE.
    Strain: 1330.

Entry informationi

Entry nameiURED2_BRUSU
AccessioniPrimary (citable) accession number: Q8FZV8
Secondary accession number(s): G0KB47
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: March 1, 2003
Last modified: June 24, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.