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Q8FZT6

- PDXJ_BRUSU

UniProt

Q8FZT6 - PDXJ_BRUSU

Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

    Catalytic activityi

    1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei8 – 813-amino-2-oxopropyl phosphateUniRule annotation
    Binding sitei19 – 1913-amino-2-oxopropyl phosphateUniRule annotation
    Active sitei44 – 441Proton acceptorUniRule annotation
    Binding sitei46 – 4611-deoxy-D-xylulose 5-phosphateUniRule annotation
    Binding sitei51 – 5111-deoxy-D-xylulose 5-phosphateUniRule annotation
    Active sitei76 – 761Proton acceptorUniRule annotation
    Binding sitei106 – 10611-deoxy-D-xylulose 5-phosphateUniRule annotation
    Sitei157 – 1571Transition state stabilizerUniRule annotation
    Active sitei198 – 1981Proton donorUniRule annotation
    Binding sitei199 – 19913-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

    GO - Biological processi

    1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00244; UER00313.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
    Short name:
    PNP synthaseUniRule annotation
    Gene namesi
    Name:pdxJUniRule annotation
    Ordered Locus Names:BR1385, BS1330_I1379
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 246246Pyridoxine 5'-phosphate synthasePRO_0000190110Add
    BLAST

    Interactioni

    Subunit structurei

    Homooctamer; tetramer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR1385.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FZT6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni221 – 22223-amino-2-oxopropyl phosphate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the PNP synthase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0854.
    HOGENOMiHOG000258095.
    KOiK03474.
    OMAiVPETRQE.
    OrthoDBiEOG6M9F0H.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_00279. PdxJ.
    InterProiIPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view]
    PfamiPF03740. PdxJ. 1 hit.
    [Graphical view]
    SUPFAMiSSF63892. SSF63892. 1 hit.
    TIGRFAMsiTIGR00559. pdxJ. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8FZT6-1 [UniParc]FASTAAdd to Basket

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    MPAKLSVNLN AIAMLRNRRD LPWPSVTGLG RAALAAGAAG LTVHPRPDQR    50
    HIRFSDLGDI RALIDDEYPQ AEFNIEGFPS EAFLDLVEKH EPEQVTLVPD 100
    DPMQATSDHG WDFMSKADFL APIVARLKGR GMRVSLFADP DSLGYERAKA 150
    IGADHVELYT GPYGATHDDP AAAARELDRL EKAARAATAL GLAVNAGHDL 200
    TVDNLPALVK RIPQLAEVSI GHGLTADALM YGIPVTVSRY ITALAG 246
    Length:246
    Mass (Da):26,447
    Last modified:March 1, 2003 - v1
    Checksum:i6E44F12BD0FC15CF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30298.1.
    CP002997 Genomic DNA. Translation: AEM18714.1.
    RefSeqiNP_698383.1. NC_004310.3.
    YP_005616206.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30298; AAN30298; BR1385.
    AEM18714; AEM18714; BS1330_I1379.
    GeneIDi1167067.
    12138418.
    KEGGibms:BR1385.
    bsi:BS1330_I1379.
    PATRICi17791125. VBIBruSui107850_1409.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30298.1 .
    CP002997 Genomic DNA. Translation: AEM18714.1 .
    RefSeqi NP_698383.1. NC_004310.3.
    YP_005616206.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8FZT6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1385.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30298 ; AAN30298 ; BR1385 .
    AEM18714 ; AEM18714 ; BS1330_I1379 .
    GeneIDi 1167067.
    12138418.
    KEGGi bms:BR1385.
    bsi:BS1330_I1379.
    PATRICi 17791125. VBIBruSui107850_1409.

    Phylogenomic databases

    eggNOGi COG0854.
    HOGENOMi HOG000258095.
    KOi K03474.
    OMAi VPETRQE.
    OrthoDBi EOG6M9F0H.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00313 .

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_00279. PdxJ.
    InterProi IPR013785. Aldolase_TIM.
    IPR004569. PyrdxlP_synth_PdxJ.
    [Graphical view ]
    Pfami PF03740. PdxJ. 1 hit.
    [Graphical view ]
    SUPFAMi SSF63892. SSF63892. 1 hit.
    TIGRFAMsi TIGR00559. pdxJ. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiPDXJ_BRUSU
    AccessioniPrimary (citable) accession number: Q8FZT6
    Secondary accession number(s): G0KB68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 30, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 67 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3