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Q8FZT6

- PDXJ_BRUSU

UniProt

Q8FZT6 - PDXJ_BRUSU

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Protein

Pyridoxine 5'-phosphate synthase

Gene

pdxJ

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate.UniRule annotation

Catalytic activityi

1-deoxy-D-xylulose 5-phosphate + 3-amino-2-oxopropyl phosphate = pyridoxine 5'-phosphate + phosphate + 2 H2O.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei8 – 813-amino-2-oxopropyl phosphateUniRule annotation
Binding sitei19 – 1913-amino-2-oxopropyl phosphateUniRule annotation
Active sitei44 – 441Proton acceptorUniRule annotation
Binding sitei46 – 4611-deoxy-D-xylulose 5-phosphateUniRule annotation
Binding sitei51 – 5111-deoxy-D-xylulose 5-phosphateUniRule annotation
Active sitei76 – 761Proton acceptorUniRule annotation
Binding sitei106 – 10611-deoxy-D-xylulose 5-phosphateUniRule annotation
Sitei157 – 1571Transition state stabilizerUniRule annotation
Active sitei198 – 1981Proton donorUniRule annotation
Binding sitei199 – 19913-amino-2-oxopropyl phosphate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. pyridoxine 5'-phosphate synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Pyridoxine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00244; UER00313.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyridoxine 5'-phosphate synthaseUniRule annotation (EC:2.6.99.2UniRule annotation)
Short name:
PNP synthaseUniRule annotation
Gene namesi
Name:pdxJUniRule annotation
Ordered Locus Names:BR1385, BS1330_I1379
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 246246Pyridoxine 5'-phosphate synthasePRO_0000190110Add
BLAST

Interactioni

Subunit structurei

Homooctamer; tetramer of dimers.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR1385.

Structurei

3D structure databases

ProteinModelPortaliQ8FZT6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni221 – 22223-amino-2-oxopropyl phosphate bindingUniRule annotation

Sequence similaritiesi

Belongs to the PNP synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0854.
HOGENOMiHOG000258095.
KOiK03474.
OMAiVPETRQE.
OrthoDBiEOG6M9F0H.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00279. PdxJ.
InterProiIPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view]
PfamiPF03740. PdxJ. 1 hit.
[Graphical view]
SUPFAMiSSF63892. SSF63892. 1 hit.
TIGRFAMsiTIGR00559. pdxJ. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FZT6 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPAKLSVNLN AIAMLRNRRD LPWPSVTGLG RAALAAGAAG LTVHPRPDQR
60 70 80 90 100
HIRFSDLGDI RALIDDEYPQ AEFNIEGFPS EAFLDLVEKH EPEQVTLVPD
110 120 130 140 150
DPMQATSDHG WDFMSKADFL APIVARLKGR GMRVSLFADP DSLGYERAKA
160 170 180 190 200
IGADHVELYT GPYGATHDDP AAAARELDRL EKAARAATAL GLAVNAGHDL
210 220 230 240
TVDNLPALVK RIPQLAEVSI GHGLTADALM YGIPVTVSRY ITALAG
Length:246
Mass (Da):26,447
Last modified:March 1, 2003 - v1
Checksum:i6E44F12BD0FC15CF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30298.1.
CP002997 Genomic DNA. Translation: AEM18714.1.
RefSeqiNP_698383.1. NC_004310.3.
YP_005616206.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30298; AAN30298; BR1385.
AEM18714; AEM18714; BS1330_I1379.
GeneIDi1167067.
12138418.
KEGGibms:BR1385.
bsi:BS1330_I1379.
PATRICi17791125. VBIBruSui107850_1409.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30298.1 .
CP002997 Genomic DNA. Translation: AEM18714.1 .
RefSeqi NP_698383.1. NC_004310.3.
YP_005616206.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8FZT6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR1385.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN30298 ; AAN30298 ; BR1385 .
AEM18714 ; AEM18714 ; BS1330_I1379 .
GeneIDi 1167067.
12138418.
KEGGi bms:BR1385.
bsi:BS1330_I1379.
PATRICi 17791125. VBIBruSui107850_1409.

Phylogenomic databases

eggNOGi COG0854.
HOGENOMi HOG000258095.
KOi K03474.
OMAi VPETRQE.
OrthoDBi EOG6M9F0H.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00313 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00279. PdxJ.
InterProi IPR013785. Aldolase_TIM.
IPR004569. PyrdxlP_synth_PdxJ.
[Graphical view ]
Pfami PF03740. PdxJ. 1 hit.
[Graphical view ]
SUPFAMi SSF63892. SSF63892. 1 hit.
TIGRFAMsi TIGR00559. pdxJ. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiPDXJ_BRUSU
AccessioniPrimary (citable) accession number: Q8FZT6
Secondary accession number(s): G0KB68
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 30, 2003
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3