Reviewed,
UniProtKB/Swiss-Prot Q8FZP4 (MURB_BRUSU)
Last modified
November 3, 2009.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: UDP-N-acetylenolpyruvoylglucosamine reductase EC=1.1.1.158 Alternative name(s): UDP-N-acetylmuramate dehydrogenase | ||||
| Gene names |
| ||||
| Organism | Brucella suis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 29461 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 322 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Cell wall formation By similarity. |
| Catalytic activity | UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH. HAMAP MF_00037 |
| Cofactor | FAD By similarity. |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00037 |
| Subcellular location | Cytoplasm Probable. |
| Sequence similarities | Belongs to the murB family. Contains 1 FAD-binding PCMH-type domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 322 | 322 | UDP-N-acetylenolpyruvoylglucosamine reductase HAMAP MF_00037 | PRO_0000179186 | |||||
Regions | |||||||||
| Domain | 36 – 202 | 167 | FAD-binding PCMH-type | ||||||
Sites | |||||||||
| Active site | 182 | 1 | By similarity | ||||||
| Active site | 231 | 1 | Proton donor By similarity | ||||||
| Active site | 301 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. Fraser C.M.Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1. |
Cross-references
Sequence databases | |
|---|---|
| AE014291 Genomic DNA. Translation: AAN30342.1. | |
| RefSeq | NP_698427.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1HSK based on UniProtKB Q93G02. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1167111. |
| GenomeReviews | Gene locus BR1429 in contig AE014291_GR. |
| KEGG | bms:BR1429. |
| NMPDR | fig|204722.1.peg.1384. |
| TIGR | BR1429. |
Phylogenomic databases | |
| HOGENOM | Q8FZP4. |
| OMA | QPIREKT. |
Enzyme and pathway databases | |
| BioCyc | BSUI204722:BR_1429-MON. |
| BRENDA | 1.1.1.158. 281610. |
Family and domain databases | |
| HAMAP | MF_00037. [Tree] |
| InterPro | IPR016169. CO_DH_flavot_FAD-bd_sub2. IPR016166. FAD-bd_2. IPR016167. FAD-bd_2_sub1. IPR003170. MurB. IPR011601. MurB_C. IPR006094. Oxid_FAD_bind_N. [Graphical view] |
| Gene3D | G3DSA:3.30.465.10. CO_DH_flavoprot_FAD-bd_sub2. 1 hit. G3DSA:3.30.43.10. FAD-binding_2_sub1. 1 hit. G3DSA:3.90.78.10. MurB_C. 1 hit. |
| PANTHER | PTHR21071. MurB. 1 hit. |
| Pfam | PF01565. FAD_binding_4. 1 hit. PF02873. MurB_C. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00179. murB. 1 hit. |
| PROSITE | PS51387. FAD_PCMH. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | MURB_BRUSU | ||||||||
| Accession | Primary (citable) accession number: Q8FZP4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella suis Brucella suis (strain 1330): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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