Q8FZF5 (LGT_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Prolipoprotein diacylglyceryl transferase
EC=2.4.99.-

Gene names

Name:	lgt
Ordered Locus Names:	BR1528, BS1330_I1522

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella › Brucella suis

Protein attributes

Sequence length	281 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins By similarity. HAMAP-Rule MF_01147
Pathway	Protein modification; lipoprotein biosynthesis (diacylglyceryl transfer). HAMAP-Rule MF_01147
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01147.
Sequence similarities	Belongs to the lgt family.

Ontologies

Keywords
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	lipoprotein biosynthetic process Inferred from electronic annotation. Source: HAMAP protein lipoylation Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 281	281	Prolipoprotein diacylglyceryl transferase HAMAP-Rule MF_01147		PRO_0000172569
Regions
	Transmembrane	27 – 46	20	Helical; Potential
	Transmembrane	71 – 90	20	Helical; Potential
	Transmembrane	105 – 127	23	Helical; Potential
	Transmembrane	134 – 156	23	Helical; Potential
	Transmembrane	188 – 210	23	Helical; Potential
	Transmembrane	217 – 234	18	Helical; Potential
	Transmembrane	249 – 271	23	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8FZF5 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 230D15039F6C1AB1	FASTA	281	31,001
	10 20 30 40 50 60 MIETLLPASA LAFPAIDPVI FRVGPLAVHW YGLGYVVGIL FAWWYGKKLL RSHRLWANNQ 70 80 90 100 110 120 PPMAPEALDD FVIWAALGVV LGGRIGYVLF YNFSYYISNP LAIPALWDGG MSFHGGILGT 130 140 150 160 170 180 TLAMILFARS RGILVWSMFD TIAAGVPIGL GVVRVANFIN SELWGRVSDV PWAVYFPNGG 190 200 210 220 230 240 PLPRHPSQLY EAFLEGLVLF FVLFVLVWGA RKLKQPGFVA GAFVTGYGLS RIAVEFFREP 250 260 270 280 DAQIGYLFGG WLTMGMVLSV PMVLLGLWAM WRANRAAARN A

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

[2]

"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014291 Genomic DNA. Translation: AAN30438.1. CP002997 Genomic DNA. Translation: AEM18854.1.
PIR	AB3313.
RefSeq	NP_698523.1. NC_004310.3. YP_005616346.1. NC_017251.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	204722.BR1528.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAN30438; AAN30438; BR1528. AEM18854; AEM18854; BS1330_I1522.
GeneID	1167211. 12137282.
KEGG	bms:BR1528. bsi:BS1330_I1522.
PATRIC	17791414. VBIBruSui107850_1552.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0682.
HOGENOM	HOG000098666.
KO	K13292.
OMA	PAHYLAH.
ProtClustDB	PRK00052.
Enzyme and pathway databases
UniPathway	UPA00664.
Family and domain databases
HAMAP	MF_01147. Lgt.
InterPro	IPR001640. Prolipoprot_diAcglycer_Trfase. [Graphical view]
Pfam	PF01790. LGT. 1 hit. [Graphical view]
TIGRFAMs	TIGR00544. lgt. 1 hit.
PROSITE	PS01311. LGT. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

LGT_BRUSU

Accession

Primary (citable) accession number: Q8FZF5
Secondary accession number(s): G0KC12

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 26, 2004
Last sequence update:	March 1, 2003
Last modified:	May 1, 2013
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program