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Q8FZ01

- RUVC_BRUSU

UniProt

Q8FZ01 - RUVC_BRUSU

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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi11 – 111MagnesiumUniRule annotation
Metal bindingi71 – 711MagnesiumUniRule annotation
Metal bindingi143 – 1431MagnesiumUniRule annotation
Metal bindingi146 – 1461MagnesiumUniRule annotation

GO - Molecular functioni

  1. crossover junction endodeoxyribonuclease activity Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. nucleic acid binding Source: InterPro

GO - Biological processi

  1. DNA recombination Source: UniProtKB-HAMAP
  2. DNA repair Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Nuclease

Keywords - Biological processi

DNA damage, DNA recombination, DNA repair

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotation
Ordered Locus Names:BR1704, BS1330_I1698
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 173173Crossover junction endodeoxyribonuclease RuvCPRO_0000183082Add
BLAST

Proteomic databases

PRIDEiQ8FZ01.

Interactioni

Protein-protein interaction databases

STRINGi204722.BR1704.

Structurei

3D structure databases

ProteinModelPortaliQ8FZ01.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0817.
HOGENOMiHOG000012181.
KOiK01159.
OMAiRQVQEMV.
OrthoDBiEOG6RG044.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00034. RuvC.
InterProiIPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view]
PfamiPF02075. RuvC. 1 hit.
[Graphical view]
PRINTSiPR00696. RSOLVASERUVC.
SUPFAMiSSF53098. SSF53098. 1 hit.
TIGRFAMsiTIGR00228. ruvC. 1 hit.
PROSITEiPS01321. RUVC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FZ01-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKETIRIIGI DPGLLRTGWG IVESLGNSLH FIGSGTVTSN AEMDLASRLC
60 70 80 90 100
QLHEGLSKVL HEFMPHEAAV EHTFVNKDAT ATLKLGQARG IALLAPAQAG
110 120 130 140 150
LPVAEYAPNA VKKAVIGVGH GEKQQIHMMV KVLMPRASFD TSDAADALAI
160 170
AICHAHHRQS IVSARRMQAL LAG
Length:173
Mass (Da):18,412
Last modified:March 1, 2003 - v1
Checksum:i757A5F8F26EC0390
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30604.1.
CP002997 Genomic DNA. Translation: AEM19021.1.
RefSeqiNP_698689.1. NC_004310.3.
YP_005616513.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30604; AAN30604; BR1704.
AEM19021; AEM19021; BS1330_I1698.
GeneIDi1167397.
12137468.
KEGGibms:BR1704.
bsi:BS1330_I1698.
PATRICi17791796. VBIBruSui107850_1731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30604.1 .
CP002997 Genomic DNA. Translation: AEM19021.1 .
RefSeqi NP_698689.1. NC_004310.3.
YP_005616513.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8FZ01.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR1704.

Proteomic databases

PRIDEi Q8FZ01.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN30604 ; AAN30604 ; BR1704 .
AEM19021 ; AEM19021 ; BS1330_I1698 .
GeneIDi 1167397.
12137468.
KEGGi bms:BR1704.
bsi:BS1330_I1698.
PATRICi 17791796. VBIBruSui107850_1731.

Phylogenomic databases

eggNOGi COG0817.
HOGENOMi HOG000012181.
KOi K01159.
OMAi RQVQEMV.
OrthoDBi EOG6RG044.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00034. RuvC.
InterProi IPR012337. RNaseH-like_dom.
IPR020563. X-over_junc_endoDNase_Mg_BS.
IPR002176. X-over_junc_endoDNase_RuvC.
[Graphical view ]
Pfami PF02075. RuvC. 1 hit.
[Graphical view ]
PRINTSi PR00696. RSOLVASERUVC.
SUPFAMi SSF53098. SSF53098. 1 hit.
TIGRFAMsi TIGR00228. ruvC. 1 hit.
PROSITEi PS01321. RUVC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiRUVC_BRUSU
AccessioniPrimary (citable) accession number: Q8FZ01
Secondary accession number(s): G0K6W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: March 1, 2003
Last modified: October 1, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3