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Q8FYX8

- PGK_BRUSU

UniProt

Q8FYX8 - PGK_BRUSU

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351SubstrateUniRule annotation
    Binding sitei117 – 1171SubstrateUniRule annotation
    Binding sitei150 – 1501SubstrateUniRule annotation
    Binding sitei200 – 2001ATPUniRule annotation
    Binding sitei322 – 3221ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi352 – 3554ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:BR1729, BS1330_I1723
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 395395Phosphoglycerate kinasePRO_0000145917Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR1729.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FYX8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 223Substrate bindingUniRule annotation
    Regioni58 – 614Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227107.
    KOiK00927.
    OMAiWEALDIG.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8FYX8-1 [UniParc]FASTAAdd to Basket

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    MFRTLDDANV QSKRVLVRID LNVPMANGEV TDLTRIERIV PTIAELSRKG    50
    AKVILLAHFG RPKGVASDEN SLKHVVKPLS KVLDHSVHFA EDCIGDKAKA 100
    AVDALKDGDV LLLENTRFHK GEEKNDPEFV QALAANGDLY VNDAFSAAHR 150
    AHASTEGLAH VLPAFAGRAM QAELEALEKG LGNPARPVVA IVGGAKVSTK 200
    LDLLSNLIEK VDALVIGGGM ANTFLAAKGL DVGKSLCEHE LASTAREIMA 250
    KAETTKCAII LPVDAVVGWH FAADTPHQTY GVDSVPGDAM ILDAGELSTD 300
    LIASAIDDAA TLVWNGPLGA FELRPFDTAT VKVARHVAKR TKEGKLVSVG 350
    GGGDTVAALN HAGVVDDFTY ISTAGGAFLE WMEGKPLPSV DVLKK 395
    Length:395
    Mass (Da):41,737
    Last modified:March 1, 2003 - v1
    Checksum:iCF00FD7FB8EBB62D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30628.1.
    CP002997 Genomic DNA. Translation: AEM19045.1.
    RefSeqiNP_698713.1. NC_004310.3.
    WP_011069042.1. NC_017251.1.
    YP_005616537.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30628; AAN30628; BR1729.
    AEM19045; AEM19045; BS1330_I1723.
    GeneIDi1167422.
    12137493.
    KEGGibms:BR1729.
    bsi:BS1330_I1723.
    PATRICi17791846. VBIBruSui107850_1756.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30628.1 .
    CP002997 Genomic DNA. Translation: AEM19045.1 .
    RefSeqi NP_698713.1. NC_004310.3.
    WP_011069042.1. NC_017251.1.
    YP_005616537.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8FYX8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR1729.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30628 ; AAN30628 ; BR1729 .
    AEM19045 ; AEM19045 ; BS1330_I1723 .
    GeneIDi 1167422.
    12137493.
    KEGGi bms:BR1729.
    bsi:BS1330_I1723.
    PATRICi 17791846. VBIBruSui107850_1756.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227107.
    KOi K00927.
    OMAi WEALDIG.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiPGK_BRUSU
    AccessioniPrimary (citable) accession number: Q8FYX8
    Secondary accession number(s): G0K6Z0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 23, 2003
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3