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Q8FYX8 (PGK_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase

EC=2.7.2.3
Gene names
Name:pgk
Ordered Locus Names:BR1729, BS1330_I1723
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length395 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate. HAMAP-Rule MF_00145

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5. HAMAP-Rule MF_00145

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00145

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00145.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 395395Phosphoglycerate kinase HAMAP-Rule MF_00145
PRO_0000145917

Regions

Nucleotide binding352 – 3554ATP By similarity
Region20 – 223Substrate binding By similarity
Region58 – 614Substrate binding By similarity

Sites

Binding site351Substrate By similarity
Binding site1171Substrate By similarity
Binding site1501Substrate By similarity
Binding site2001ATP By similarity
Binding site3221ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FYX8 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: CF00FD7FB8EBB62D

FASTA39541,737
        10         20         30         40         50         60 
MFRTLDDANV QSKRVLVRID LNVPMANGEV TDLTRIERIV PTIAELSRKG AKVILLAHFG 

        70         80         90        100        110        120 
RPKGVASDEN SLKHVVKPLS KVLDHSVHFA EDCIGDKAKA AVDALKDGDV LLLENTRFHK 

       130        140        150        160        170        180 
GEEKNDPEFV QALAANGDLY VNDAFSAAHR AHASTEGLAH VLPAFAGRAM QAELEALEKG 

       190        200        210        220        230        240 
LGNPARPVVA IVGGAKVSTK LDLLSNLIEK VDALVIGGGM ANTFLAAKGL DVGKSLCEHE 

       250        260        270        280        290        300 
LASTAREIMA KAETTKCAII LPVDAVVGWH FAADTPHQTY GVDSVPGDAM ILDAGELSTD 

       310        320        330        340        350        360 
LIASAIDDAA TLVWNGPLGA FELRPFDTAT VKVARHVAKR TKEGKLVSVG GGGDTVAALN 

       370        380        390 
HAGVVDDFTY ISTAGGAFLE WMEGKPLPSV DVLKK 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN30628.1.
CP002997 Genomic DNA. Translation: AEM19045.1.
RefSeqNP_698713.1. NC_004310.3.
YP_005616537.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8FYX8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR1729.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30628; AAN30628; BR1729.
AEM19045; AEM19045; BS1330_I1723.
GeneID1167422.
12137493.
KEGGbms:BR1729.
bsi:BS1330_I1723.
PATRIC17791846. VBIBruSui107850_1756.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMADMIFDIG.
OrthoDBEOG64N9Z0.
ProtClustDBPRK00073.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
HAMAPMF_00145. Phosphoglyc_kinase.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. SSF53748. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_BRUSU
AccessionPrimary (citable) accession number: Q8FYX8
Secondary accession number(s): G0K6Z0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: March 1, 2003
Last modified: February 19, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names