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Q8FYW3 (PURE_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
N5-carboxyaminoimidazole ribonucleotide mutase

Short name=N5-CAIR mutase
EC=5.4.99.18
Alternative name(s):
5-(carboxyamino)imidazole ribonucleotide mutase
Gene names
Name:purE
Ordered Locus Names:BR1744, BS1330_I1738
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length162 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) By similarity.

Catalytic activity

5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.

Subunit structure

Homooctamer By similarity.

Sequence similarities

Belongs to the AIR carboxylase family.

Ontologies

Keywords
   Biological processPurine biosynthesis
   Molecular functionIsomerase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process'de novo' IMP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_function5-(carboxyamino)imidazole ribonucleotide mutase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 162162N5-carboxyaminoimidazole ribonucleotide mutase
PRO_0000074971

Sites

Binding site111Substrate By similarity
Binding site141Substrate By similarity
Binding site411Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FYW3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: 30424E164EB1788B

FASTA16216,637
        10         20         30         40         50         60 
MSVDVAIIMG SQSDWETMRH AAHTLEALGI SFDARIVSAH RTPDRLVAFA KGAKAEGFKV 

        70         80         90        100        110        120 
IIAGAGGAAH LPGMAAAMTP LPVFGVPVQS KALSGQDSLL SIVQMPAGIP VGTLAIGRAG 

       130        140        150        160 
AVNAALLAAA VLALYDEALA ARLDEWRKAQ TESVAERPSN EA 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN30643.1.
CP002997 Genomic DNA. Translation: AEM19060.1.
RefSeqNP_698728.1. NC_004310.3.
YP_005616552.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8FYW3.
SMRQ8FYW3. Positions 5-161.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR1744.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30643; AAN30643; BR1744.
AEM19060; AEM19060; BS1330_I1738.
GeneID1167437.
12137508.
KEGGbms:BR1744.
bsi:BS1330_I1738.
PATRIC17791878. VBIBruSui107850_1772.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0041.
HOGENOMHOG000034140.
KOK01588.
OMAKQVISAH.
OrthoDBEOG6Z0QH2.
ProtClustDBCLSK898071.

Enzyme and pathway databases

UniPathwayUPA00074; UER00943.

Family and domain databases

Gene3D3.40.50.7700. 1 hit.
InterProIPR024694. N5-CAIR_mutase_PurE.
IPR000031. PurE_dom.
[Graphical view]
PfamPF00731. AIRC. 1 hit.
[Graphical view]
PIRSFPIRSF001338. AIR_carboxylase. 1 hit.
SMARTSM01001. AIRC. 1 hit.
[Graphical view]
SUPFAMSSF52255. SSF52255. 1 hit.
TIGRFAMsTIGR01162. purE. 1 hit.
ProtoNetSearch...

Other

PROQ8FYW3.

Entry information

Entry namePURE_BRUSU
AccessionPrimary (citable) accession number: Q8FYW3
Secondary accession number(s): G0K784
Entry history
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: March 1, 2003
Last modified: December 11, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names