Reviewed,
UniProtKB/Swiss-Prot Q8FYW3 (PUR6_BRUSU)
Last modified
February 9, 2010.
Version 45.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Phosphoribosylaminoimidazole carboxylase catalytic subunit EC=4.1.1.21 Alternative name(s): AIR carboxylase Short name=AIRC | ||||
| Gene names |
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| Organism | Brucella suis [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 29461 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 162 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition By similarity. |
| Catalytic activity | 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2. |
| Pathway | |
| Subunit structure | Homooctamer By similarity. |
| Sequence similarities | Belongs to the AIR carboxylase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Purine biosynthesis |
| Molecular function | Decarboxylase Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | 'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro |
| Molecular function | phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. Fraser C.M.Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE014291 Genomic DNA. Translation: AAN30643.1. |
| RefSeq | NP_698728.1. |
3D structure databases | |
| SMR | Q8FYW3. Positions 5-161. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1167437. |
| GenomeReviews | Gene locus BR1744 in contig AE014291_GR. |
| KEGG | bms:BR1744. |
| NMPDR | fig|204722.1.peg.1685. |
| TIGR | BR1744. |
Phylogenomic databases | |
| HOGENOM | HBG301965. |
| OMA | QSDWATM. |
| PhylomeDB | Q8FYW3. |
Enzyme and pathway databases | |
| BioCyc | BSUI204722:BR_1744-MONOMER. |
| BRENDA | 4.1.1.21. 281610. |
Family and domain databases | |
| InterPro | IPR000031. AIR_COase_core. [Graphical view] |
| Gene3D | G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit. |
| PANTHER | PTHR23046. AIR_carboxyl. 1 hit. |
| Pfam | PF00731. AIRC. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01162. purE. 1 hit. |
| ProtoNet | Search... |
Entry information
| Entry name | PUR6_BRUSU | ||||||||
| Accession | Primary (citable) accession number: Q8FYW3 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Brucella suis Brucella suis (strain 1330): entries and gene names |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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