Reviewed, UniProtKB/Swiss-Prot Q8FYW3 (PUR6_BRUSU)

Names and origin

Protein names

Recommended name:
    Phosphoribosylaminoimidazole carboxylase catalytic subunit
    EC=4.1.1.21
Alternative name(s):
    AIR carboxylase
      Short name=AIRC

Gene names

Name:	purE
Ordered Locus Names:	BR1744

Organism

Brucella suis [Complete proteome] [HAMAP]

Taxonomic identifier

29461 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	162 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	This subunit can alone transform AIR to CAIR, but in association with purK, which possesses an ATPase activity, an enzyme complex is produced which is capable of converting AIR to CAIR efficiently under physiological condition By similarity.
Catalytic activity	5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2.
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-amino-1-(5-phospho-D-ribosyl)imidazole (carboxylase route): step 1/1.
Subunit structure	Homooctamer By similarity.
Sequence similarities	Belongs to the AIR carboxylase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	phosphoribosylaminoimidazole carboxylase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 162	162	Phosphoribosylaminoimidazole carboxylase catalytic subunit		PRO_0000074971
Sites
	Binding site	11	1	Substrate By similarity
	Binding site	14	1	Substrate By similarity
	Binding site	41	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8FYW3-1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 30424E164EB1788B	FASTA	162	16,637
	10 20 30 40 50 60 MSVDVAIIMG SQSDWETMRH AAHTLEALGI SFDARIVSAH RTPDRLVAFA KGAKAEGFKV 70 80 90 100 110 120 IIAGAGGAAH LPGMAAAMTP LPVFGVPVQS KALSGQDSLL SIVQMPAGIP VGTLAIGRAG 130 140 150 160 AVNAALLAAA VLALYDEALA ARLDEWRKAQ TESVAERPSN EA

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330 / Biovar 1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014291 Genomic DNA. Translation: AAN30643.1.
RefSeq	NP_698728.1.
3D structure databases
SMR	Q8FYW3. Positions 5-161.
ModBase	Search...
Genome annotation databases
GeneID	1167437.
GenomeReviews	Gene locus BR1744 in contig AE014291_GR.
KEGG	bms:BR1744.
NMPDR	fig|204722.1.peg.1685.
TIGR	BR1744.
Phylogenomic databases
HOGENOM	HBG301965.
OMA	QSDWATM.
PhylomeDB	Q8FYW3.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_1744-MONOMER.
BRENDA	4.1.1.21. 281610.
Family and domain databases
InterPro	IPR000031. AIR_COase_core. [Graphical view]
Gene3D	G3DSA:3.40.50.7700. AIR_carboxyl. 1 hit.
PANTHER	PTHR23046. AIR_carboxyl. 1 hit.
Pfam	PF00731. AIRC. 1 hit. [Graphical view]
TIGRFAMs	TIGR01162. purE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR6_BRUSU

Accession

Primary (citable) accession number: Q8FYW3

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 7, 2003
Last sequence update:	March 1, 2003
Last modified:	February 9, 2010
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)