Q8FYV1 (THIB_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Thiamine-binding periplasmic protein

Gene names

Name:	thiB
Synonyms:	tbpA
Ordered Locus Names:	BR1757, BS1330_I1751

Organism

Brucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]

Taxonomic identifier

204722 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length	334 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Part of the ABC transporter complex thiBPQ involved in thiamine import By similarity.
Subunit structure	The complex is composed of two ATP-binding proteins (thiQ), two transmembrane proteins (thiP) and a solute-binding protein (thiB) Probable.
Subcellular location	Periplasm By similarity.
Sequence similarities	Belongs to the bacterial solute-binding protein 1 family.

Ontologies

Keywords
Biological process	Transport
Cellular component	Periplasm
Domain	Signal
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	outer membrane-bounded periplasmic space Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 23	23	Potential
	Chain	24 – 334	311	Thiamine-binding periplasmic protein		PRO_0000282914

Sequences

	Sequence		Length	Mass (Da)
	Q8FYV1 [UniParc]. Last modified March 1, 2003. Version 1. Checksum: 117BE09E521E1771	FASTA	334	36,727
	10 20 30 40 50 60 MRLLSLLTFS LFAVIGLAPA AQAKDTLTIY TYDSFVSEWG PGPKVKENFE KECDCEVNFV 70 80 90 100 110 120 ASADGVALLN RLKLEGSKTA ADIVLGLDTN LTTEARASGF FAPSGIDQTN VKVPGNFKDD 130 140 150 160 170 180 IFVPYDYGYF AVVYDSEKLP NPPKSLKELV EGDPAQKIVL QDPRTATPGL GMLLWMKSVY 190 200 210 220 230 240 GDEAGAAWQK LQKRVLTVTP GWSEAYGLFT KGESPMVLSY TTSPAYHMVV EKTDRYKALA 250 260 270 280 290 300 YPEGNYLQIE LAAQTTTGAK NPLAKKFLAF MTGPGFQDVI PETNWMFPAG KTSKPLPAAF 310 320 330 DALPKPEKTL LIPPYEVAKN RRLWVNEWLA ATSR

References

[1]

"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts." Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M. Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed: 12271122] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

[2]

"Revised genome sequence of Brucella suis 1330." Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R. J. Bacteriol. 193:6410-6410(2011) [PubMed: 22038969] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 1330.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014291 Genomic DNA. Translation: AAN30656.1. CP002997 Genomic DNA. Translation: AEM19073.1.
RefSeq	NP_698741.1. NC_004310.3.
3D structure databases
ProteinModelPortal	Q8FYV1.
SMR	Q8FYV1. Positions 24-333.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1167450.
GenomeReviews	Gene locus BR1757 in contig AE014291_GR.
KEGG	bms:BR1757.
NMPDR	fig|204722.1.peg.1698.
PATRIC	17791902. VBIBruSui107850_1784.
TIGR	BR1757.
Phylogenomic databases
HOGENOM	HBG476839.
OMA	IPTTNWM.
PhylomeDB	Q8FYV1.
ProtClustDB	PRK11205.
Enzyme and pathway databases
BioCyc	BSUI204722:BR_1757-MONOMER.
Family and domain databases
InterPro	IPR006059. Solute-bd_1_bac. IPR005948. Thi_ABC_peri-bd. IPR005967. ThiB_ABC_peri-bd. [Graphical view]
KO	K02064.
Pfam	PF01547. SBP_bac_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01254. SfuA. 1 hit. TIGR01276. ThiB. 1 hit.
PROSITE	PS01037. SBP_BACTERIAL_1. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

THIB_BRUSU

Accession

Primary (citable) accession number: Q8FYV1
Secondary accession number(s): G0K797

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2007
Last sequence update:	March 1, 2003
Last modified:	January 25, 2012
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program