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Q8FYR3 (ATPA_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ATP synthase subunit alpha

EC=3.6.3.14
Alternative name(s):
ATP synthase F1 sector subunit alpha
F-ATPase subunit alpha
Gene names
Name:atpA
Ordered Locus Names:BR1801, BS1330_I1795
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length509 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit By similarity. HAMAP-Rule MF_01346

Catalytic activity

ATP + H2O + H+(In) = ADP + phosphate + H+(Out). HAMAP-Rule MF_01346

Subunit structure

F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a1, b2 and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF1 is attached to CF0 by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains By similarity.

Subcellular location

Cell inner membrane; Peripheral membrane protein By similarity HAMAP-Rule MF_01346.

Sequence similarities

Belongs to the ATPase alpha/beta chains family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 509509ATP synthase subunit alpha HAMAP-Rule MF_01346
PRO_0000238216

Regions

Nucleotide binding169 – 1768ATP By similarity

Sites

Site3701Required for activity By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FYR3 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: D6ED094014D258B9

FASTA50954,916
        10         20         30         40         50         60 
MDIRAAEISA ILKEQIKNFG KEAEVSEVGQ VLSVGDGIAR VYGLDNVQAG EMVEFPGGIR 

        70         80         90        100        110        120 
GMALNLESDN VGVVIFGADR DIKEGDVVKR TGAIVDVPVG PELLGRVVDA LGNPIDGKGP 

       130        140        150        160        170        180 
IKAKERRRVD VKAPGIIPRK SVHEPMSTGL KAIDALIPVG RGQRELVIGD RQTGKTAIIL 

       190        200        210        220        230        240 
DTFLNQKPIH DNGPDKDKLY CVYVAVGQKR STVAQFVKVL EERGALEYSI VVAATASDPA 

       250        260        270        280        290        300 
PMQYLAPFAG CAMGEYFRDN GQHALIGYDD LSKQAVAYRQ MSLLLRRPPG REAYPGDVFY 

       310        320        330        340        350        360 
LHSRLLERAA KLNDENGAGS LTALPVIETQ GNDVSAFIPT NVISITDGQI FLETNLFYQG 

       370        380        390        400        410        420 
IRPAVNVGLS VSRVGSSAQI KAMKQVAGSI KGELAQHREM AAFAQFGSDL DAATQRLLNR 

       430        440        450        460        470        480 
GARLTELLKQ PQFSPLKTEE QVAVIYAGVN GYLDKLAVNQ VGKFEEGLLA SLRTEHKDVL 

       490        500 
EGIRNEKALT DDLKAKLKAA IDAFAKSFA 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN30696.1.
CP002997 Genomic DNA. Translation: AEM19113.1.
RefSeqNP_698781.1. NC_004310.3.
YP_005616605.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8FYR3.
SMRQ8FYR3. Positions 24-501.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR1801.

Proteomic databases

PRIDEQ8FYR3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30696; AAN30696; BR1801.
AEM19113; AEM19113; BS1330_I1795.
GeneID1167494.
12137565.
KEGGbms:BR1801.
bsi:BS1330_I1795.
PATRIC17791992. VBIBruSui107850_1829.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0056.
HOGENOMHOG000130111.
KOK02111.
OMAIRPSEIS.
OrthoDBEOG67X1S1.

Family and domain databases

Gene3D2.40.30.20. 1 hit.
3.40.50.300. 1 hit.
HAMAPMF_01346. ATP_synth_alpha_bact.
InterProIPR020003. ATPase_a/bsu_AS.
IPR023366. ATPase_asu-like.
IPR005294. ATPase_F1-cplx_asu.
IPR000793. ATPase_F1/V1/A1-cplx_a/bsu_C.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR004100. ATPase_F1_a/bsu_N.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF00006. ATP-synt_ab. 1 hit.
PF00306. ATP-synt_ab_C. 1 hit.
PF02874. ATP-synt_ab_N. 1 hit.
[Graphical view]
SUPFAMSSF47917. SSF47917. 1 hit.
SSF50615. SSF50615. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00962. atpA. 1 hit.
PROSITEPS00152. ATPASE_ALPHA_BETA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameATPA_BRUSU
AccessionPrimary (citable) accession number: Q8FYR3
Secondary accession number(s): G0K7D7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Brucella suis

Brucella suis (strain 1330): entries and gene names