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Protein

DNA translocase FtsK

Gene

ftsK

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Translocation stops specifically at Xer-dif sites, where FtsK interacts with the Xer recombinase, allowing activation of chromosome unlinking by recombination. FtsK orienting polar sequences (KOPS) guide the direction of DNA translocation. FtsK can remove proteins from DNA as it translocates, but translocation stops specifically at XerCD-dif site, thereby preventing removal of XerC and XerD from dif (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi509 – 514ATPPROSITE-ProRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Chromosome partition

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
DNA translocase FtsK
Gene namesi
Name:ftsK
Ordered Locus Names:BS1330_I1889, BR1895
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
Proteomesi
  • UP000007104 Componenti: Chromosome I

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 51HelicalSequence analysisAdd BLAST21
Transmembranei87 – 107HelicalSequence analysisAdd BLAST21
Transmembranei118 – 138HelicalSequence analysisAdd BLAST21
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Transmembranei174 – 194HelicalSequence analysisAdd BLAST21
Transmembranei226 – 246HelicalSequence analysisAdd BLAST21
Topological domaini247 – 854CytoplasmicSequence analysisAdd BLAST608

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000982441 – 854DNA translocase FtsKAdd BLAST854

Proteomic databases

PRIDEiQ8FYI0.

Interactioni

Subunit structurei

Homohexamer. Forms a ring that surrounds DNA (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8FYI0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini489 – 708FtsKPROSITE-ProRule annotationAdd BLAST220

Domaini

Consists of an N-terminal domain, which is sufficient for the localization to the septal ring and is required for cell division, followed by a linker domain, and a C-terminal domain, which forms the translocation motor involved in chromosome segregation. The C-terminal domain can be further subdivided into alpha, beta and gamma subdomains. The alpha and beta subdomains multimerise to produce a hexameric ring, contain the nucleotide binding motif and form the DNA pump. The gamma subdomain is a regulatory subdomain that controls translocation of DNA by recognition of KOPS motifs and interacts with XerD recombinase (By similarity).By similarity

Sequence similaritiesi

Belongs to the FtsK/SpoIIIE/SftA family.Curated
Contains 1 FtsK domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000010003.
KOiK03466.
OMAiQECRLIM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025199. FtsK_4TM.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13491. FtsK_4TM. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FYI0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQGYSPSYP LRDERITEDR LRFANLVRRQ VYILLGLGLL SLTAMAVGAL
60 70 80 90 100
ATWNVADPSF SHATDNPVTN ALGYPGAVFS DLAMQFFGLA SVPALLPLAV
110 120 130 140 150
WSLLLMIRGY IGRIARRSLA WVGAALLFAA IASCLAVPQS WPMPIGLGGV
160 170 180 190 200
FGDMLLRIPG FFLGGFPQGA IASAIALVLA FPALWFCFFA SGIIGRGAEA
210 220 230 240 250
VNPAMLSANR SADDEFADED ADNEAGGGFH FIGALTHLVL MTTATIRRMT
260 270 280 290 300
GLGRRRSRED DFDDMRMVRR SAETRNAPRR EPGFGAPAAD DEPPFDMDDM
310 320 330 340 350
DDGAPLAGQE WHDAPPPRAR KARVEQAAPS PKPGPRAQRE AQPSFLKDNG
360 370 380 390 400
IFEMPSLHFL AEPKLVQRDP ALSKDALEQN ARLLEGVLED FGVRGEIINV
410 420 430 440 450
KPGPVVTLYE LEPAPGIKSS RVIGLADDIA RSMSAIAARV AVIPGRNAIG
460 470 480 490 500
IELPNPKREM VYLREMLASR DFEQSKAKLA LALGKTINGE PVIADIAKMP
510 520 530 540 550
HVLVAGTTGS GKSVAINTMI LSLLYRMTPQ ECRLIMIDPK MLELSVYDGI
560 570 580 590 600
PHLLTPVVTD PKKAVVALKW TVREMEDRYR KMSKVGVRNI DGFNQRVGLA
610 620 630 640 650
QKKGEPIART VQTGFDRNTG EAIYETEELD LEPMPYIVVI IDEMADLMMV
660 670 680 690 700
AGKDIEGAVQ RLAQMARAAG IHVIMATQRP SVDVITGTIK ANFPTRISFQ
710 720 730 740 750
VTSKIDSRTI LGEQGAEQLL GQGDMLFMAG GGRIQRVHGP FVGDDEVERI
760 770 780 790 800
VQHLKLQGVP EYLDAITEDE DDDEGGSGPA GTGNLEDSDD PYDQAVAVVL
810 820 830 840 850
RDKKASTSYI QRRLGIGYNR AASIIERMED EGIVGPANHA GKREILVPTG

DDDF
Length:854
Mass (Da):92,780
Last modified:March 1, 2003 - v1
Checksum:i2BD08EF8B5454CAC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30788.1.
CP002997 Genomic DNA. Translation: AEM19205.1.
RefSeqiWP_006190925.1. NZ_KN046804.1.

Genome annotation databases

EnsemblBacteriaiAAN30788; AAN30788; BR1895.
AEM19205; AEM19205; BS1330_I1889.
KEGGibms:BR1895.
bsi:BS1330_I1889.
PATRICi17792209. VBIBruSui107850_1929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014291 Genomic DNA. Translation: AAN30788.1.
CP002997 Genomic DNA. Translation: AEM19205.1.
RefSeqiWP_006190925.1. NZ_KN046804.1.

3D structure databases

ProteinModelPortaliQ8FYI0.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ8FYI0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAN30788; AAN30788; BR1895.
AEM19205; AEM19205; BS1330_I1889.
KEGGibms:BR1895.
bsi:BS1330_I1889.
PATRICi17792209. VBIBruSui107850_1929.

Phylogenomic databases

HOGENOMiHOG000010003.
KOiK03466.
OMAiQECRLIM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR025199. FtsK_4TM.
IPR002543. FtsK_dom.
IPR018541. Ftsk_gamma.
IPR027417. P-loop_NTPase.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF13491. FtsK_4TM. 1 hit.
PF09397. Ftsk_gamma. 1 hit.
PF01580. FtsK_SpoIIIE. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00843. Ftsk_gamma. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS50901. FTSK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFTSK_BRUSU
AccessioniPrimary (citable) accession number: Q8FYI0
Secondary accession number(s): G0K839
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: March 1, 2003
Last modified: October 5, 2016
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.