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Q8FYF7

- ODO1_BRUSU

UniProt

Q8FYF7 - ODO1_BRUSU

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Protein

2-oxoglutarate dehydrogenase E1 component

Gene
sucA, odhA, BR1923, BS1330_I1917
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO2. It contains multiple copies of three enzymatic components: 2-oxoglutarate dehydrogenase (E1), dihydrolipoamide succinyltransferase (E2) and lipoamide dehydrogenase (E3) By similarity.UniRule annotation

Catalytic activityi

2-oxoglutarate + [dihydrolipoyllysine-residue succinyltransferase] lipoyllysine = [dihydrolipoyllysine-residue succinyltransferase] S-succinyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

Thiamine pyrophosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. oxoglutarate dehydrogenase (succinyl-transferring) activity Source: UniProtKB-EC
  2. thiamine pyrophosphate binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Thiamine pyrophosphate

Names & Taxonomyi

Protein namesi
Recommended name:
2-oxoglutarate dehydrogenase E1 component (EC:1.2.4.2)
Alternative name(s):
Alpha-ketoglutarate dehydrogenase
Gene namesi
Name:sucA
Synonyms:odhA
Ordered Locus Names:BR1923, BS1330_I1917
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 100410042-oxoglutarate dehydrogenase E1 componentUniRule annotationPRO_0000162171Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR1923.

Structurei

3D structure databases

ProteinModelPortaliQ8FYF7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0567.
HOGENOMiHOG000259586.
KOiK00164.
OMAiGHQNANL.
OrthoDBiEOG6V1M1F.

Family and domain databases

Gene3Di3.40.50.970. 2 hits.
HAMAPiMF_01169. SucA_OdhA.
InterProiIPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view]
PANTHERiPTHR23152. PTHR23152. 1 hit.
PfamiPF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view]
PIRSFiPIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 2 hits.
TIGRFAMsiTIGR00239. 2oxo_dh_E1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FYF7-1 [UniParc]FASTAAdd to Basket

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MAKQEQAPDR ANDVFALTSF LYGGNADYIE ELYAKYEDDP NSVDPQWRDF     50
FAKLGDNADD VKKNAEGPSW TRKNWPIAAN GELVSALDGN WAEVEKHVTD 100
KLKGKAAKGE AKGAAGTPLT AEEITQAARD SVRAIMMIRA YRMRGHLHAN 150
LDPLGLAEKP NDYNELEPEN YGFTPADYNR KIFIDNVLGL EYATVPEMLD 200
ILKRTYCGAI GVEFMHISDP AEKAWIQERI EGPDKKVAFT PEGKKAILSK 250
LIEAEGFEQF IDVKYKGTKR FGLDGGESLI PALEQIVKRG GQMGLKEVVL 300
GMAHRGRLNV LSQVMGKPHR AIFHEFKGGS YTPDDVEGSG DVKYHLGASS 350
DREFDGNKVH LSLTANPSHL EIVNPVVMGK ARAKQDLLVG RTRDDMVPLS 400
ERAKVLPLLL HGDAAFAGQG VVAECLGLSG LKGHRVAGTL HFIINNQIGF 450
TTNPAFSRSS PYPSDVAKMI EAPIFHVNGD DPEAVVFAAK VATEFRMTFH 500
KPVVIDMFCY RRFGHNEGDE PSFTQPLMYK AIRAHKTTVQ LYGEKLIAEG 550
LVTQDDIDRM KADWRQKLEG EFEAGQSYKP NKADWLDGAW AGLRTADNAD 600
EQRRGKTAVP VKTLKEIGKK LVEVPKDFHV HRTIQRFLDN RAKMMETGEG 650
IDWATAESLA FGSLAVEGHP IRLSGQDVER GTFSQRHTVL YDQENQNRYI 700
PLNNLQKGQA IYEAINSMLS EEAVLGYEYG YSLSDPRALV LWEAQFGDFA 750
NGAQVVFDQF ISSGERKWLR MSGLVCLLPH GFEGQGPEHS SARLERYLQL 800
CAEDNMQVAN VTTPANYFHI LRRQMKRDFR KPLIMMTPKS LLRHKRAIST 850
LAELSGESSF HRLLWDDAQY NKDEGIKLQK DAKIRRVVLC SGKVYYDLYE 900
EREKRGIDDV YLLRVEQLYP FPAKALINEL SRFRHAEMVW CQEEPKNMGA 950
WSFIDPYLEW VLAHIDAKHQ RVRYAGRPAA ASPATGLMSK HLAQLAAFLE 1000
DALG 1004
Length:1,004
Mass (Da):112,681
Last modified:March 1, 2003 - v1
Checksum:i390B507D3018DD46
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30815.1.
CP002997 Genomic DNA. Translation: AEM19232.1.
RefSeqiNP_698900.1. NC_004310.3.
YP_005616724.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30815; AAN30815; BR1923.
AEM19232; AEM19232; BS1330_I1917.
GeneIDi1167623.
12137701.
KEGGibms:BR1923.
bsi:BS1330_I1917.
PATRICi17792267. VBIBruSui107850_1958.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30815.1 .
CP002997 Genomic DNA. Translation: AEM19232.1 .
RefSeqi NP_698900.1. NC_004310.3.
YP_005616724.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8FYF7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR1923.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN30815 ; AAN30815 ; BR1923 .
AEM19232 ; AEM19232 ; BS1330_I1917 .
GeneIDi 1167623.
12137701.
KEGGi bms:BR1923.
bsi:BS1330_I1917.
PATRICi 17792267. VBIBruSui107850_1958.

Phylogenomic databases

eggNOGi COG0567.
HOGENOMi HOG000259586.
KOi K00164.
OMAi GHQNANL.
OrthoDBi EOG6V1M1F.

Family and domain databases

Gene3Di 3.40.50.970. 2 hits.
HAMAPi MF_01169. SucA_OdhA.
InterProi IPR011603. 2oxoglutarate_DH_E1.
IPR023784. 2oxoglutarate_DH_E1_bac.
IPR001017. DH_E1.
IPR029061. THDP-binding.
IPR005475. Transketolase-like_Pyr-bd.
[Graphical view ]
PANTHERi PTHR23152. PTHR23152. 1 hit.
Pfami PF00676. E1_dh. 1 hit.
PF02779. Transket_pyr. 1 hit.
[Graphical view ]
PIRSFi PIRSF000157. Oxoglu_dh_E1. 1 hit.
SMARTi SM00861. Transket_pyr. 1 hit.
[Graphical view ]
SUPFAMi SSF52518. SSF52518. 2 hits.
TIGRFAMsi TIGR00239. 2oxo_dh_E1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiODO1_BRUSU
AccessioniPrimary (citable) accession number: Q8FYF7
Secondary accession number(s): G0K866
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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