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Q8FY59

- AROK_BRUSU

UniProt

Q8FY59 - AROK_BRUSU

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Protein

Shikimate kinase

Gene

aroK

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

Catalytic activityi

ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

Cofactori

Binds 1 magnesium ion per subunit.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi37 – 371MagnesiumUniRule annotation
Binding sitei55 – 551SubstrateUniRule annotation
Binding sitei79 – 791SubstrateUniRule annotation
Binding sitei101 – 1011Substrate; via amide nitrogenUniRule annotation
Binding sitei139 – 1391ATPUniRule annotation
Binding sitei158 – 1581SubstrateUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi33 – 386ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. shikimate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
  2. chorismate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00053; UER00088.

Names & Taxonomyi

Protein namesi
Recommended name:
Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
Short name:
SKUniRule annotation
Gene namesi
Name:aroKUniRule annotation
Ordered Locus Names:BR2029, BS1330_I2023
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 200200Shikimate kinasePRO_0000237856Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi204722.BR2029.

Structurei

3D structure databases

ProteinModelPortaliQ8FY59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the shikimate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0703.
HOGENOMiHOG000032568.
KOiK00891.
OMAiADIPWIF.
OrthoDBiEOG6SJJGD.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00109. Shikimate_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
[Graphical view]
PfamiPF01202. SKI. 1 hit.
[Graphical view]
PRINTSiPR01100. SHIKIMTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8FY59-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGTNKQTNL HRQTETIRQL LGSKVVVLVG LMGAGKSTIG RKVANMLNLP
60 70 80 90 100
FKDADTEIET VSRMTVAELF EAYGEVEFRD LERRVILRLL DDGPMVLATG
110 120 130 140 150
GGAYMNAETR AAIAEAGISI WINADLDVLM ERVSRRQNRP LLRNSDPRGV
160 170 180 190 200
MQRLMDERYP VYALAELHLM TRDEKKEVIA AELIEVLAAH LEKEQAASAG
Length:200
Mass (Da):22,235
Last modified:March 1, 2003 - v1
Checksum:iF11D503663A80C62
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30919.1.
CP002997 Genomic DNA. Translation: AEM19336.1.
RefSeqiNP_699004.1. NC_004310.3.
YP_005616828.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30919; AAN30919; BR2029.
AEM19336; AEM19336; BS1330_I2023.
GeneIDi1167731.
12137811.
KEGGibms:BR2029.
bsi:BS1330_I2023.
PATRICi17792485. VBIBruSui107850_2064.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30919.1 .
CP002997 Genomic DNA. Translation: AEM19336.1 .
RefSeqi NP_699004.1. NC_004310.3.
YP_005616828.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8FY59.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR2029.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN30919 ; AAN30919 ; BR2029 .
AEM19336 ; AEM19336 ; BS1330_I2023 .
GeneIDi 1167731.
12137811.
KEGGi bms:BR2029.
bsi:BS1330_I2023.
PATRICi 17792485. VBIBruSui107850_2064.

Phylogenomic databases

eggNOGi COG0703.
HOGENOMi HOG000032568.
KOi K00891.
OMAi ADIPWIF.
OrthoDBi EOG6SJJGD.

Enzyme and pathway databases

UniPathwayi UPA00053 ; UER00088 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
HAMAPi MF_00109. Shikimate_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
[Graphical view ]
Pfami PF01202. SKI. 1 hit.
[Graphical view ]
PRINTSi PR01100. SHIKIMTKNASE.
SUPFAMi SSF52540. SSF52540. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiAROK_BRUSU
AccessioniPrimary (citable) accession number: Q8FY59
Secondary accession number(s): G0K8P9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3