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Q8FY59 (AROK_BRUSU) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Shikimate kinase

Short name=SK
EC=2.7.1.71
Gene names
Name:aroK
Ordered Locus Names:BR2029, BS1330_I2023
OrganismBrucella suis biovar 1 (strain 1330) [Complete proteome] [HAMAP]
Taxonomic identifier204722 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length200 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate By similarity. HAMAP-Rule MF_00109

Catalytic activity

ATP + shikimate = ADP + shikimate 3-phosphate. HAMAP-Rule MF_00109

Cofactor

Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_00109

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 5/7. HAMAP-Rule MF_00109

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00109

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00109.

Sequence similarities

Belongs to the shikimate kinase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Magnesium
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

chorismate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

magnesium ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

shikimate kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 200200Shikimate kinase HAMAP-Rule MF_00109
PRO_0000237856

Regions

Nucleotide binding33 – 386ATP By similarity

Sites

Metal binding371Magnesium By similarity
Binding site551Substrate By similarity
Binding site791Substrate By similarity
Binding site1011Substrate; via amide nitrogen By similarity
Binding site1391ATP By similarity
Binding site1581Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8FY59 [UniParc].

Last modified March 1, 2003. Version 1.
Checksum: F11D503663A80C62

FASTA20022,235
        10         20         30         40         50         60 
MSGTNKQTNL HRQTETIRQL LGSKVVVLVG LMGAGKSTIG RKVANMLNLP FKDADTEIET 

        70         80         90        100        110        120 
VSRMTVAELF EAYGEVEFRD LERRVILRLL DDGPMVLATG GGAYMNAETR AAIAEAGISI 

       130        140        150        160        170        180 
WINADLDVLM ERVSRRQNRP LLRNSDPRGV MQRLMDERYP VYALAELHLM TRDEKKEVIA 

       190        200 
AELIEVLAAH LEKEQAASAG 

« Hide

References

[1]"The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts."
Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F., Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J., Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R., Nelson W.C., Ayodeji B., Kraul M. expand/collapse author list , Shetty J., Malek J.A., Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O., Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M., Fraser C.M.
Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.
[2]"Revised genome sequence of Brucella suis 1330."
Tae H., Shallom S., Settlage R., Preston D., Adams L.G., Garner H.R.
J. Bacteriol. 193:6410-6410(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: 1330.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE014291 Genomic DNA. Translation: AAN30919.1.
CP002997 Genomic DNA. Translation: AEM19336.1.
RefSeqNP_699004.1. NC_004310.3.
YP_005616828.1. NC_017251.1.

3D structure databases

ProteinModelPortalQ8FY59.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING204722.BR2029.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAN30919; AAN30919; BR2029.
AEM19336; AEM19336; BS1330_I2023.
GeneID1167731.
12137811.
KEGGbms:BR2029.
bsi:BS1330_I2023.
PATRIC17792485. VBIBruSui107850_2064.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0703.
HOGENOMHOG000032568.
KOK00891.
OMAADIPWIF.
OrthoDBEOG6SJJGD.
ProtClustDBPRK13946.

Enzyme and pathway databases

UniPathwayUPA00053; UER00088.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00109. Shikimate_kinase.
InterProIPR027417. P-loop_NTPase.
IPR000623. Shikimate_kinase/TSH1.
[Graphical view]
PfamPF01202. SKI. 1 hit.
[Graphical view]
PRINTSPR01100. SHIKIMTKNASE.
SUPFAMSSF52540. SSF52540. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROK_BRUSU
AccessionPrimary (citable) accession number: Q8FY59
Secondary accession number(s): G0K8P9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: March 1, 2003
Last modified: April 16, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Brucella suis

Brucella suis (strain 1330): entries and gene names