Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8FY59

- AROK_BRUSU

UniProt

Q8FY59 - AROK_BRUSU

Protein

Shikimate kinase

Gene

aroK

Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Mar 2003)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.UniRule annotation

    Catalytic activityi

    ATP + shikimate = ADP + shikimate 3-phosphate.UniRule annotation

    Cofactori

    Binds 1 magnesium ion per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi37 – 371MagnesiumUniRule annotation
    Binding sitei55 – 551SubstrateUniRule annotation
    Binding sitei79 – 791SubstrateUniRule annotation
    Binding sitei101 – 1011Substrate; via amide nitrogenUniRule annotation
    Binding sitei139 – 1391ATPUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi33 – 386ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. shikimate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. aromatic amino acid family biosynthetic process Source: UniProtKB-HAMAP
    2. chorismate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00053; UER00088.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Shikimate kinaseUniRule annotation (EC:2.7.1.71UniRule annotation)
    Short name:
    SKUniRule annotation
    Gene namesi
    Name:aroKUniRule annotation
    Ordered Locus Names:BR2029, BS1330_I2023
    OrganismiBrucella suis biovar 1 (strain 1330)
    Taxonomic identifieri204722 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 200200Shikimate kinasePRO_0000237856Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi204722.BR2029.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8FY59.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the shikimate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0703.
    HOGENOMiHOG000032568.
    KOiK00891.
    OMAiADIPWIF.
    OrthoDBiEOG6SJJGD.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    HAMAPiMF_00109. Shikimate_kinase.
    InterProiIPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    [Graphical view]
    PfamiPF01202. SKI. 1 hit.
    [Graphical view]
    PRINTSiPR01100. SHIKIMTKNASE.
    SUPFAMiSSF52540. SSF52540. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q8FY59-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGTNKQTNL HRQTETIRQL LGSKVVVLVG LMGAGKSTIG RKVANMLNLP    50
    FKDADTEIET VSRMTVAELF EAYGEVEFRD LERRVILRLL DDGPMVLATG 100
    GGAYMNAETR AAIAEAGISI WINADLDVLM ERVSRRQNRP LLRNSDPRGV 150
    MQRLMDERYP VYALAELHLM TRDEKKEVIA AELIEVLAAH LEKEQAASAG 200
    Length:200
    Mass (Da):22,235
    Last modified:March 1, 2003 - v1
    Checksum:iF11D503663A80C62
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30919.1.
    CP002997 Genomic DNA. Translation: AEM19336.1.
    RefSeqiNP_699004.1. NC_004310.3.
    YP_005616828.1. NC_017251.1.

    Genome annotation databases

    EnsemblBacteriaiAAN30919; AAN30919; BR2029.
    AEM19336; AEM19336; BS1330_I2023.
    GeneIDi1167731.
    12137811.
    KEGGibms:BR2029.
    bsi:BS1330_I2023.
    PATRICi17792485. VBIBruSui107850_2064.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE014291 Genomic DNA. Translation: AAN30919.1 .
    CP002997 Genomic DNA. Translation: AEM19336.1 .
    RefSeqi NP_699004.1. NC_004310.3.
    YP_005616828.1. NC_017251.1.

    3D structure databases

    ProteinModelPortali Q8FY59.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 204722.BR2029.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAN30919 ; AAN30919 ; BR2029 .
    AEM19336 ; AEM19336 ; BS1330_I2023 .
    GeneIDi 1167731.
    12137811.
    KEGGi bms:BR2029.
    bsi:BS1330_I2023.
    PATRICi 17792485. VBIBruSui107850_2064.

    Phylogenomic databases

    eggNOGi COG0703.
    HOGENOMi HOG000032568.
    KOi K00891.
    OMAi ADIPWIF.
    OrthoDBi EOG6SJJGD.

    Enzyme and pathway databases

    UniPathwayi UPA00053 ; UER00088 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    HAMAPi MF_00109. Shikimate_kinase.
    InterProi IPR027417. P-loop_NTPase.
    IPR000623. Shikimate_kinase/TSH1.
    [Graphical view ]
    Pfami PF01202. SKI. 1 hit.
    [Graphical view ]
    PRINTSi PR01100. SHIKIMTKNASE.
    SUPFAMi SSF52540. SSF52540. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: 1330.

    Entry informationi

    Entry nameiAROK_BRUSU
    AccessioniPrimary (citable) accession number: Q8FY59
    Secondary accession number(s): G0K8P9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2006
    Last sequence update: March 1, 2003
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. Brucella suis
      Brucella suis (strain 1330): entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3