ID   AROE_BRUSU              Reviewed;         289 AA.
AC   Q8FY21;
DT   07-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT   07-NOV-2003, sequence version 2.
DT   16-JUN-2009, entry version 42.
DE   RecName: Full=Shikimate dehydrogenase;
DE            EC=1.1.1.25;
GN   Name=aroE; OrderedLocusNames=BR2069;
OS   Brucella suis.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Brucellaceae; Brucella.
OX   NCBI_TaxID=29461;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=1330 / Biovar 1;
RX   MEDLINE=22247741; PubMed=12271122; DOI=10.1073/pnas.192319099;
RA   Paulsen I.T., Seshadri R., Nelson K.E., Eisen J.A., Heidelberg J.F.,
RA   Read T.D., Dodson R.J., Umayam L.A., Brinkac L.M., Beanan M.J.,
RA   Daugherty S.C., DeBoy R.T., Durkin A.S., Kolonay J.F., Madupu R.,
RA   Nelson W.C., Ayodeji B., Kraul M., Shetty J., Malek J.A.,
RA   Van Aken S.E., Riedmuller S., Tettelin H., Gill S.R., White O.,
RA   Salzberg S.L., Hoover D.L., Lindler L.E., Halling S.M., Boyle S.M.,
RA   Fraser C.M.;
RT   "The Brucella suis genome reveals fundamental similarities between
RT   animal and plant pathogens and symbionts.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:13148-13153(2002).
CC   -!- CATALYTIC ACTIVITY: Shikimate + NADP(+) = 3-dehydroshikimate +
CC       NADPH.
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and PEP:
CC       step 4/7.
CC   -!- SIMILARITY: Belongs to the shikimate dehydrogenase family.
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DR   EMBL; AE014291; AAN30959.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_699044.1; -.
DR   HSSP; P43876; 1P77.
DR   GeneID; 1167772; -.
DR   GenomeReviews; AE014291_GR; BR2069.
DR   KEGG; bms:BR2069; -.
DR   NMPDR; fig|204722.1.peg.2001; -.
DR   TIGR; BR2069; -.
DR   HOGENOM; Q8FY21; -.
DR   BioCyc; BSUI204722:BR_2069-MON; -.
DR   BRENDA; 1.1.1.25; 281610.
DR   GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR   GO; GO:0050661; F:NADP or NADPH binding; IEA:InterPro.
DR   GO; GO:0004764; F:shikimate 5-dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic pro...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00222; -; 1.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR011342; Quinate/shikimate_5-DH.
DR   InterPro; IPR013708; Shikimate_DH-bd_N.
DR   InterPro; IPR006151; Shikm_DH/Glu-tRNA_Rdtase.
DR   Gene3D; G3DSA:3.40.50.720; NAD(P)-bd; 1.
DR   Pfam; PF01488; Shikimate_DH; 1.
DR   Pfam; PF08501; Shikimate_dh_N; 1.
DR   TIGRFAMs; TIGR00507; aroE; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Aromatic amino acid biosynthesis;
KW   Complete proteome; NADP; Oxidoreductase.
FT   CHAIN         1    289       Shikimate dehydrogenase.
FT                                /FTId=PRO_0000135994.
FT   NP_BIND     134    138       NADP (By similarity).
FT   ACT_SITE     73     73       Proton acceptor (Potential).
SQ   SEQUENCE   289 AA;  30407 MW;  BE867B20C895E43B CRC64;
     MDDKSMARGR KAFVTGFPIK HSRSPLIHGF WLKELGIDGS YEAVEVKPED FSSFAASLAA
     NGFAGGNVTI PHKEAAYAAA ESLDEAACAI GAVNTLWLEN GRLCGGNTDA YGFAANLDAS
     APGWDKADRA LVLGAGGASR AVVHALLSRG VCHVSVVNRT LSRAEELAAH FGARVYAHGW
     DEAQALVSNA GLIVNTTALG MSGHGEGQDF PIDLTCAPKE AVATNIVYVP LRTAFLNKAE
     KAGLKTVDGL GMLLHQAVPG FERWFGQRPQ VTQALREHIL ADMAKAGAL
//