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Q8FXY7

- ACCD_BRUSU

UniProt

Q8FXY7 - ACCD_BRUSU

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Protein

Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

Gene
accD, BR2107, BS1330_I2101
Organism
Brucella suis biovar 1 (strain 1330)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO2 group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA By similarity.UniRule annotation

Catalytic activityi

ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. acetyl-CoA carboxylase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-KW

GO - Biological processi

  1. fatty acid biosynthetic process Source: UniProtKB-HAMAP
  2. malonyl-CoA biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00655; UER00711.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta (EC:6.4.1.2)
Short name:
ACCase subunit beta
Short name:
Acetyl-CoA carboxylase carboxyltransferase subunit beta
Gene namesi
Name:accD
Ordered Locus Names:BR2107, BS1330_I2101
OrganismiBrucella suis biovar 1 (strain 1330)
Taxonomic identifieri204722 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000000824: Chromosome I, UP000007104: Chromosome I

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. acetyl-CoA carboxylase complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 301301Acetyl-coenzyme A carboxylase carboxyl transferase subunit betaUniRule annotationPRO_0000389707Add
BLAST

Interactioni

Subunit structurei

Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD) By similarity.

Protein-protein interaction databases

STRINGi204722.BR2107.

Structurei

3D structure databases

ProteinModelPortaliQ8FXY7.

Family & Domainsi

Sequence similaritiesi

Belongs to the AccD/PCCB family.

Phylogenomic databases

eggNOGiCOG0777.
HOGENOMiHOG000021670.
KOiK01963.
OMAiYISVMTD.
OrthoDBiEOG6HQSSF.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
HAMAPiMF_01395. AcetylCoA_CT_beta.
InterProiIPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011762. COA_CT_N.
[Graphical view]
PfamiPF01039. Carboxyl_trans. 1 hit.
[Graphical view]
PRINTSiPR01070. ACCCTRFRASEB.
SUPFAMiSSF52096. SSF52096. 1 hit.
TIGRFAMsiTIGR00515. accD. 1 hit.
PROSITEiPS50980. COA_CT_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8FXY7-1 [UniParc]FASTAAdd to Basket

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MNWITNYVRP KINSMLGRRE MPENLWIKDP STGEMVFHKD LESNQFVIPS    50
SGHHMRIKAK DRLRFFFDNG EYTTLEAPKV PLDPLKFRDE KKYIDRLKDY 100
RSRTGMDDAI VNGLGTIEGL PIVATVQDFS FMGGSLGMGA GEAIIQGFEK 150
AIELKRPLVL FASSGGARMQ EGILSLMQLP RTTVAVEMLK EAGLPYIVVL 200
TNPTTGGVTA SYAMLGDIHI AEPGALIGFA GPRVIEQTIR EKLPEGFQSS 250
EYLMEHGMVD MVVSRLELKA TIARLLKIMT KQPANSDAPA PQKPDADSKA 300
A 301
Length:301
Mass (Da):33,270
Last modified:March 1, 2003 - v1
Checksum:iBCB69B33AEA8D566
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30997.1.
CP002997 Genomic DNA. Translation: AEM19414.1.
PIRiAF3504.
RefSeqiNP_699082.1. NC_004310.3.
YP_005616906.1. NC_017251.1.

Genome annotation databases

EnsemblBacteriaiAAN30997; AAN30997; BR2107.
AEM19414; AEM19414; BS1330_I2101.
GeneIDi1167810.
12137890.
KEGGibms:BR2107.
bsi:BS1330_I2101.
PATRICi17792647. VBIBruSui107850_2144.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE014291 Genomic DNA. Translation: AAN30997.1 .
CP002997 Genomic DNA. Translation: AEM19414.1 .
PIRi AF3504.
RefSeqi NP_699082.1. NC_004310.3.
YP_005616906.1. NC_017251.1.

3D structure databases

ProteinModelPortali Q8FXY7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 204722.BR2107.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAN30997 ; AAN30997 ; BR2107 .
AEM19414 ; AEM19414 ; BS1330_I2101 .
GeneIDi 1167810.
12137890.
KEGGi bms:BR2107.
bsi:BS1330_I2101.
PATRICi 17792647. VBIBruSui107850_2144.

Phylogenomic databases

eggNOGi COG0777.
HOGENOMi HOG000021670.
KOi K01963.
OMAi YISVMTD.
OrthoDBi EOG6HQSSF.

Enzyme and pathway databases

UniPathwayi UPA00655 ; UER00711 .

Family and domain databases

Gene3Di 3.90.226.10. 1 hit.
HAMAPi MF_01395. AcetylCoA_CT_beta.
InterProi IPR000438. Acetyl_CoA_COase_Trfase_b_su.
IPR000022. Carboxyl_trans.
IPR029045. ClpP/crotonase-like_dom.
IPR011762. COA_CT_N.
[Graphical view ]
Pfami PF01039. Carboxyl_trans. 1 hit.
[Graphical view ]
PRINTSi PR01070. ACCCTRFRASEB.
SUPFAMi SSF52096. SSF52096. 1 hit.
TIGRFAMsi TIGR00515. accD. 1 hit.
PROSITEi PS50980. COA_CT_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 1330.

Entry informationi

Entry nameiACCD_BRUSU
AccessioniPrimary (citable) accession number: Q8FXY7
Secondary accession number(s): G0K955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 2009
Last sequence update: March 1, 2003
Last modified: June 11, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Brucella suis
    Brucella suis (strain 1330): entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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